PMID- 38449009
OWN - NLM
STAT- MEDLINE
DCOM- 20240308
LR  - 20240315
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 45
IP  - 2
DP  - 2024 Mar 1
TI  - Factors influencing the quality of life in children with atopic dermatitis in 
      Korea: A multicenter cross-sectional study.
PG  - 112-119
LID - 10.2500/aap.2024.45.230094 [doi]
AB  - Background: There is a lack of studies about which factors affect the quality of 
      life (QoL) in children with atopic dermatitis (AD), although it is well known 
      that AD has considerably negative effects on their QoL. Objective: This study 
      aimed to measure the QoL in children with AD and identify the factors that affect 
      their QoL. Methods: A questionnaire derived from the Children's Dermatology Life 
      Quality Index (CDLQI) was used to measure QoL. Family history, allergic 
      comorbidities, exacerbation-related factors, time of exacerbation, and previous 
      and current treatment were also evaluated. The total immunoglobulin E (IgE) level 
      and specific IgE sensitization were determined by the multiple allergen 
      simultaneous test, allergy test, or skin-prick test. AD severity was categorized 
      into mild, moderate, and severe based on treatments. Results: In total, 254 
      children (46.4 months, 53% boys) from seven hospitals completed the survey. The 
      mean CDLQI score was 7.2 +/- 5.5 (total score range of 0-30). The respondents were 
      divided into three groups according to their QoL score distribution, with 0 - 4 
      points (n = 84), 5 - 9 points (n = 90), and >/=10 points (n = 80) representing 
      good, fair, and poor QoL, respectively. The more severe AD showed the higher 
      CDLQI score significantly (p = 0.001). Compared with other groups, children with 
      poor QoL were more sensitized to inhalant allergens (odds ratio [OR] 1.29 [95% 
      confidence interval CI], 1.03 - 1.62) and had more exacerbating factors (OR 
      1.26 [95% CI, 1.04 - 1.54]), which included inhalation allergen-related 
      exacerbating factors (OR 2.54 [95% CI, 1.23 - 5.23), even after adjusting for 
      age, total IgE, body mass index, severity, and use of moisturizer. The 
      concordance between animal sensitization and an exacerbating factor, including 
      dog and cat, was fair, with 0.39 kappa and 0.85 accuracy. Conclusion: This study 
      showed that impaired QoL in children with AD is associated with inhalant allergen 
      sensitization and inhalant allergen-related exacerbation factors. Especially, dog 
      and cat sensitization was a significant exacerbating factor. The 
      inhalation-related exacerbation factors, including animal allergens, might be 
      addressed to improve AD management in children.
FAU - Park, Mireu
AU  - Park M
AD  - From the Department of Pediatrics, Severance Hospital, Yonsei University College 
      of Medicine, Seoul, Korea.
FAU - Yum, Hye Yung
AU  - Yum HY
AD  - Department of Pediatrics, Seoul Medical Center, Seoul, Korea.
FAU - Bae, Jung Min
AU  - Bae JM
AD  - Department of Dermatology, St. Vincent's Hospital, College of Medicine, The 
      Catholic University of Korea, Suwon, Korea.
FAU - Lee, Sooyoung
AU  - Lee S
AD  - Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
FAU - Sung, Myongsoon
AU  - Sung M
AD  - Department of Pediatrics, Soonchunhyang University Gumi Hospital, Soonchunhyang 
      University School of Medicine, Gumi, Korea.
FAU - Yang, Song-I
AU  - Yang SI
AD  - Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym 
      University College of Medicine, Anyang, Korea.
FAU - Lee, Jeongmin
AU  - Lee J
AD  - Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, 
      Korea.
FAU - Lee, Mi Hee
AU  - Lee MH
AD  - Department of Pediatrics, Incheon Medical Center, Incheon, Korea.
FAU - Lee, Dong Hun
AU  - Lee DH
AD  - Department of Dermatology, Seoul National University Hospital, Seoul, Korea, and.
FAU - Kim, Yoon Hee
AU  - Kim YH
AD  - Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College 
      of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Allergens
MH  - *Cat Diseases
MH  - Cross-Sectional Studies
MH  - *Dermatitis, Atopic/epidemiology
MH  - *Dog Diseases
MH  - Immunoglobulin E
MH  - Quality of Life
MH  - Republic of Korea/epidemiology
EDAT- 2024/03/07 00:42
MHDA- 2024/03/08 06:43
CRDT- 2024/03/06 23:48
PHST- 2024/03/08 06:43 [medline]
PHST- 2024/03/07 00:42 [pubmed]
PHST- 2024/03/06 23:48 [entrez]
AID - 10.2500/aap.2024.45.230094 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2024 Mar 1;45(2):112-119. doi: 10.2500/aap.2024.45.230094.