PMID- 38449069
OWN - NLM
STAT- Publisher
LR  - 20240306
IS  - 1573-4056 (Electronic)
DP  - 2024 Feb 28
TI  - The Correlation between Region-specific Epicardial Adipose Tissue and Myocardial 
      Ischemia Defined by CT-FFR in Type 2 Diabetes Mellitus Patients.
LID - 10.2174/0115734056291770240105101731 [doi]
AB  - BACKGROUND: Epicardial Adipose Tissue (EAT) accumulation is closely associated 
      with the presence and severity of coronary artery disease (CAD), myocardial 
      ischemia, plaque vulnerability, and major adverse cardiovascular events. 
      OBJECTIVE: The aim of this study was to investigate the correlation between 
      myocardial ischemia defined by computed tomography-derived fractional flow 
      reserve (CT-FFR) and region-specific EAT in patients with type 2 diabetes 
      mellitus (T2DM). METHODS: Between January 2022 and May 2023, 200 T2DM patients 
      were randomly selected from the Department of Endocrinology in The Central 
      Hospital of Wuhan. These patients were divided into two groups based on 
      myocardial ischemia defined by CT-FFR: myocardial ischemia group (152 cases) and 
      control group (48 cases). Both groups of patients used a post-treatment 
      workstation to measure the thickness of region-specific EAT. Receiver operating 
      characteristic (ROC) curve analysis and binary logistic regression were used to 
      evaluate the correlation between various parameters and myocardial ischemia. 
      RESULTS: Patients in the myocardial ischemia group had significantly higher 
      values of age, male gender, systolic blood pressure, total cholesterol, 
      triglycerides, LDL, HDL, fasting blood glucose, fasting insulin, HOMA-IR, EAT 
      thickness in right ventricular wall, left atrioventricular groove, and superior 
      and inferior interventricular groove. ROC curve analysis results showed that EAT 
      thickness in the left atrioventricular groove had the largest area under the ROC 
      curve for diagnosing myocardial ischemia (0.837 [95% CI 0.766-0.865]; P < 0.001). 
      Binary logistic regression analysis showed that EAT thickness in the left 
      atrioventricular groove was an independent risk factor for myocardial ischemia in 
      patients with T2DM (P < 0.05). CONCLUSION: The EAT thickness in the left 
      atrioventricular groove is an independent risk factor for myocardial ischemia in 
      patients with T2DM. Adipose tissue in the left atrioventricular groove region 
      plays a major role in EAT-mediated CAD.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Wang, Zheng
AU  - Wang Z
AUID- ORCID: 0000-0002-8291-2825
AD  - Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, P.R. China.
FAU - Huang, Zengfa
AU  - Huang Z
AD  - Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, P.R. China.
FAU - Wang, Xiang
AU  - Wang X
AD  - Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20240228
PL  - United Arab Emirates
TA  - Curr Med Imaging
JT  - Current medical imaging
JID - 101762461
SB  - IM
OTO - NOTNLM
OT  - Coronary computed tomography
OT  - Epicardial adipose tissue
OT  - Fractional flow reserve.
OT  - Myocardial ischemia
OT  - Patients
OT  - Type 2 diabetes mellitus
EDAT- 2024/03/07 00:42
MHDA- 2024/03/07 00:42
CRDT- 2024/03/06 23:52
PHST- 2023/11/27 00:00 [received]
PHST- 2023/12/26 00:00 [revised]
PHST- 2023/12/30 00:00 [accepted]
PHST- 2024/03/07 00:42 [medline]
PHST- 2024/03/07 00:42 [pubmed]
PHST- 2024/03/06 23:52 [entrez]
AID - CMIR-EPUB-138848 [pii]
AID - 10.2174/0115734056291770240105101731 [doi]
PST - aheadofprint
SO  - Curr Med Imaging. 2024 Feb 28. doi: 10.2174/0115734056291770240105101731.