PMID- 38451304 OWN - NLM STAT- MEDLINE DCOM- 20240430 LR - 20240508 IS - 1745-1701 (Electronic) IS - 0586-7614 (Print) IS - 0586-7614 (Linking) VI - 50 IP - 3 DP - 2024 Apr 30 TI - Accelerating Medicines Partnership(R) Schizophrenia (AMP(R) SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis. PG - 496-512 LID - 10.1093/schbul/sbae011 [doi] AB - This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership(R) Schizophrenia (AMP(R) SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals. CI - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. FAU - Wannan, Cassandra M J AU - Wannan CMJ AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Nelson, Barnaby AU - Nelson B AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Addington, Jean AU - Addington J AD - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. FAU - Allott, Kelly AU - Allott K AUID- ORCID: 0000-0002-0640-4634 AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Anticevic, Alan AU - Anticevic A AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Arango, Celso AU - Arango C AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Maranon, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain. FAU - Baker, Justin T AU - Baker JT AD - Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA. FAU - Bearden, Carrie E AU - Bearden CE AUID- ORCID: 0000-0002-8516-923X AD - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Billah, Tashrif AU - Billah T AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Bouix, Sylvain AU - Bouix S AD - Department of Software Engineering and Information Technology, Ecole de technologie superieure, Montreal, Canada. FAU - Broome, Matthew R AU - Broome MR AD - School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK. AD - Early Intervention for Psychosis Services, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. FAU - Buccilli, Kate AU - Buccilli K AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Cadenhead, Kristin S AU - Cadenhead KS AUID- ORCID: 0000-0002-5952-4605 AD - Department of Psychiatry, University of California, San Diego, CA, USA. FAU - Calkins, Monica E AU - Calkins ME AUID- ORCID: 0000-0002-0546-0263 AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Cannon, Tyrone D AU - Cannon TD AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Department of Psychology, Yale University, New Haven, CT, USA. FAU - Cecci, Guillermo AU - Cecci G AUID- ORCID: 0000-0003-1013-8348 AD - IBM T.J. Watson Research Center, Yorktown Heights, NY, USA. FAU - Chen, Eric Yu Hai AU - Chen EYH AD - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong. FAU - Cho, Kang Ik K AU - Cho KIK AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Choi, Jimmy AU - Choi J AD - Olin Neuropsychiatry Research Center, Hartford Hospital, Hartford, CT, USA. FAU - Clark, Scott R AU - Clark SR AD - Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia. AD - Basil Hetzel Institute, Woodville, SA, Australia. FAU - Coleman, Michael J AU - Coleman MJ AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Conus, Philippe AU - Conus P AD - General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. FAU - Corcoran, Cheryl M AU - Corcoran CM AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. AD - Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA. FAU - Diaz-Caneja, Covadonga M AU - Diaz-Caneja CM AUID- ORCID: 0000-0001-8538-3175 AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Maranon, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain. FAU - Dwyer, Dominic AU - Dwyer D AUID- ORCID: 0000-0003-3949-5867 AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Ebdrup, Bjorn H AU - Ebdrup BH AD - Centre for Neuropsychiatric Schizophrenia Research, CNSR Mental Health Centre, Glostrup, Copenhagen, Denmark. FAU - Ellman, Lauren M AU - Ellman LM AD - Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. FAU - Fusar-Poli, Paolo AU - Fusar-Poli P AD - Department of Psychosis Studies, King's College London, London, UK. AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. FAU - Galindo, Liliana AU - Galindo L AD - Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. AD - Department of Psychiatry, University of Cambridge, Cambridge, UK. FAU - Gaspar, Pablo A AU - Gaspar PA AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Gerber, Carla AU - Gerber C AD - Behavioral Health Services, PeaceHealth Medical Group, Eugene, OR, USA. FAU - Glenthoj, Louise Birkedal AU - Glenthoj LB AD - Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Denmark. AD - Department of Psychology, University of Copenhagen, Copenhagen, Denmark. FAU - Glynn, Robert AU - Glynn R AD - Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. AD - Department of Biostatistics, Harvard T.H. Chan School of Public Health and Harvard Medical School, Boston, MA, USA. FAU - Harms, Michael P AU - Harms MP AD - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. FAU - Horton, Leslie E AU - Horton LE AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Kahn, Rene S AU - Kahn RS AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Kambeitz, Joseph AU - Kambeitz J AUID- ORCID: 0000-0002-8988-3959 AD - Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. FAU - Kambeitz-Ilankovic, Lana AU - Kambeitz-Ilankovic L AD - Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. FAU - Kane, John M AU - Kane JM AUID- ORCID: 0000-0002-2628-9442 AD - Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. AD - Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA. FAU - Kapur, Tina AU - Kapur T AD - Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. FAU - Keshavan, Matcheri S AU - Keshavan MS AD - Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. FAU - Kim, Sung-Wan AU - Kim SW AUID- ORCID: 0000-0002-6739-2163 AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. AD - Mindlink, Gwangju Bukgu Mental Health Center, Gwangju, Korea. FAU - Koutsouleris, Nikolaos AU - Koutsouleris N AD - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany. FAU - Kubicki, Marek AU - Kubicki M AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. FAU - Kwon, Jun Soo AU - Kwon JS AUID- ORCID: 0000-0002-1060-1462 AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. AD - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. FAU - Langbein, Kerstin AU - Langbein K AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. FAU - Lewandowski, Kathryn E AU - Lewandowski KE AD - Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA. FAU - Light, Gregory A AU - Light GA AD - Department of Psychiatry, University of California, San Diego, CA, USA. AD - Veterans Affairs San Diego Health Care System, San Diego, CA, USA. FAU - Mamah, Daniel AU - Mamah D AD - Department of Psychiatry, Washington University Medical School, St. Louis, MO, USA. FAU - Marcy, Patricia J AU - Marcy PJ AD - Northwell Health, Glen Oaks, NY, USA. FAU - Mathalon, Daniel H AU - Mathalon DH AD - Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. AD - Mental Health Service 116D, Veterans Affairs San Francisco Health Care System, San Francisco, CA, USA. FAU - McGorry, Patrick D AU - McGorry PD AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Mittal, Vijay A AU - Mittal VA AUID- ORCID: 0000-0001-9017-5119 AD - Department of Psychology, Northwestern University, Evanston, IL, USA. FAU - Nordentoft, Merete AU - Nordentoft M AD - Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Nunez, Angela AU - Nunez A AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Pasternak, Ofer AU - Pasternak O AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. FAU - Pearlson, Godfrey D AU - Pearlson GD AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Olin Neuropsychiatry Research Center, Hartford Hospital, Hartford, CT, USA. FAU - Perez, Jesus AU - Perez J AD - CAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. AD - Department of Medicine, Institute of Biomedical Research (IBSAL), Universidad de Salamanca, Salamanca, Spain. FAU - Perkins, Diana O AU - Perkins DO AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. FAU - Powers, Albert R 3rd AU - Powers AR 3rd AUID- ORCID: 0000-0003-3057-5043 AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Roalf, David R AU - Roalf DR AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Sabb, Fred W AU - Sabb FW AD - Prevention Science Institute, University of Oregon, Eugene, OR, USA. FAU - Schiffman, Jason AU - Schiffman J AD - Department of Psychological Science, University of California, Irvine, Irvine, CA, USA. FAU - Shah, Jai L AU - Shah JL AD - PEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada. AD - Department of Psychiatry, McGill University, Montreal, Quebec, Canada. FAU - Smesny, Stefan AU - Smesny S AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. FAU - Spark, Jessica AU - Spark J AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Stone, William S AU - Stone WS AUID- ORCID: 0000-0003-2932-7288 AD - Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. FAU - Strauss, Gregory P AU - Strauss GP AD - Department of Psychology, University of Georgia, Athens, GA, USA. FAU - Tamayo, Zailyn AU - Tamayo Z AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Torous, John AU - Torous J AUID- ORCID: 0000-0002-5362-7937 AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. FAU - Upthegrove, Rachel AU - Upthegrove R AD - Department of Software Engineering and Information Technology, Ecole de technologie superieure, Montreal, Canada. AD - Birmingham Womens and Childrens, NHS Foundation Trust, Birmingham, UK. FAU - Vangel, Mark AU - Vangel M AD - Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. FAU - Verma, Swapna AU - Verma S AD - Department of Psychosis, Institute of Mental Health, Singapore. FAU - Wang, Jijun AU - Wang J AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Rossum, Inge Winter-van AU - Rossum IW AD - Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA. FAU - Wolf, Daniel H AU - Wolf DH AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Wolff, Phillip AU - Wolff P AD - Department of Psychology, Emory University, Atlanta, GA, USA. FAU - Wood, Stephen J AU - Wood SJ AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. AD - School of Psychology, University of Birmingham, Edgbaston, UK. FAU - Yung, Alison R AU - Yung AR AD - Institute of Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia. AD - School of Health Sciences, University of Manchester, Manchester, UK. FAU - Agurto, Carla AU - Agurto C AD - IBM T.J. Watson Research Center, Yorktown Heights, NY, USA. FAU - Alvarez-Jimenez, Mario AU - Alvarez-Jimenez M AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Amminger, Paul AU - Amminger P AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Armando, Marco AU - Armando M AD - Youth Early Detection/Intervention in Psychosis Platform (Plateforme ERA), Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital and The University of Lausanne, Lausanne, Switzerland. FAU - Asgari-Targhi, Ameneh AU - Asgari-Targhi A AD - Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. FAU - Cahill, John AU - Cahill J AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Carrion, Ricardo E AU - Carrion RE AD - Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. AD - Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA. FAU - Castro, Eduardo AU - Castro E AD - IBM T.J. Watson Research Center, Yorktown Heights, NY, USA. FAU - Cetin-Karayumak, Suheyla AU - Cetin-Karayumak S AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Mallar Chakravarty, M AU - Mallar Chakravarty M AD - Department of Psychiatry, McGill University, Montreal, Quebec, Canada. FAU - Cho, Youngsun T AU - Cho YT AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Cotter, David AU - Cotter D AD - Department Psychiatry, Beaumont Hospital, Dublin 9, Ireland. AD - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin 2, Ireland. FAU - D'Alfonso, Simon AU - D'Alfonso S AD - School of Computing and Information Systems, The University of Melbourne, Parkville, VIC, Australia. FAU - Ennis, Michaela AU - Ennis M AUID- ORCID: 0000-0001-7898-8184 AD - Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA. FAU - Fadnavis, Shreyas AU - Fadnavis S AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Fonteneau, Clara AU - Fonteneau C AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Gao, Caroline AU - Gao C AUID- ORCID: 0000-0002-0987-2759 AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Gupta, Tina AU - Gupta T AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Gur, Raquel E AU - Gur RE AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Gur, Ruben C AU - Gur RC AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Hamilton, Holly K AU - Hamilton HK AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Hoftman, Gil D AU - Hoftman GD AD - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Jacobs, Grace R AU - Jacobs GR AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Jarcho, Johanna AU - Jarcho J AD - Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. FAU - Ji, Jie Lisa AU - Ji JL AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Kohler, Christian G AU - Kohler CG AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Lalousis, Paris Alexandros AU - Lalousis PA AD - School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK. AD - Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK. FAU - Lavoie, Suzie AU - Lavoie S AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Lepage, Martin AU - Lepage M AD - Department of Psychiatry, McGill University, Montreal, Quebec, Canada. FAU - Liebenthal, Einat AU - Liebenthal E AD - Program for Specialized Treatment Early in Psychosis (STEP), CMHC, New Haven, CT, USA. FAU - Mervis, Josh AU - Mervis J AD - Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. FAU - Murty, Vishnu AU - Murty V AD - Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. FAU - Nicholas, Spero C AU - Nicholas SC AD - Department of Psychiatry, Washington University Medical School, St. Louis, MO, USA. FAU - Ning, Lipeng AU - Ning L AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. FAU - Penzel, Nora AU - Penzel N AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Poldrack, Russell AU - Poldrack R AD - Department of Psychology, Stanford University, Stanford, CA, USA. FAU - Polosecki, Pablo AU - Polosecki P AD - IBM T.J. Watson Research Center, Yorktown Heights, NY, USA. FAU - Pratt, Danielle N AU - Pratt DN AD - Department of Psychology, Northwestern University, Evanston, IL, USA. FAU - Rabin, Rachel AU - Rabin R AD - PEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada. FAU - Rahimi Eichi, Habiballah AU - Rahimi Eichi H AD - Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA. FAU - Rathi, Yogesh AU - Rathi Y AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. AD - Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. FAU - Reichenberg, Avraham AU - Reichenberg A AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Reinen, Jenna AU - Reinen J AD - IBM T.J. Watson Research Center, Yorktown Heights, NY, USA. FAU - Rogers, Jack AU - Rogers J AD - Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK. FAU - Ruiz-Yu, Bernalyn AU - Ruiz-Yu B AD - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Scott, Isabelle AU - Scott I AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Seitz-Holland, Johanna AU - Seitz-Holland J AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Srihari, Vinod H AU - Srihari VH AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Program for Specialized Treatment Early in Psychosis (STEP), CMHC, New Haven, CT, USA. FAU - Srivastava, Agrima AU - Srivastava A AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Thompson, Andrew AU - Thompson A AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Turetsky, Bruce I AU - Turetsky BI AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Walsh, Barbara C AU - Walsh BC AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Whitford, Thomas AU - Whitford T AD - Orygen, Parkville, VIC, Australia. AD - School of Psychology, University of New South Wales (UNSW), Kensington, NSW, Australia. FAU - Wigman, Johanna T W AU - Wigman JTW AD - Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center,Groningen, Netherlands. FAU - Yao, Beier AU - Yao B AD - Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA. FAU - Yuen, Hok Pan AU - Yuen HP AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Ahmed, Uzair AU - Ahmed U AD - Orygen, Parkville, VIC, Australia. FAU - Byun, Andrew Jin Soo AU - Byun AJS AD - Division of Digital Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. AD - John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. FAU - Chung, Yoonho AU - Chung Y AD - Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA. FAU - Do, Kim AU - Do K AD - Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, Switzerland. AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience King's College London, London, UK. FAU - Hendricks, Larry AU - Hendricks L AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Huynh, Kevin AU - Huynh K AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Jeffries, Clark AU - Jeffries C AD - Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA. FAU - Lane, Erlend AU - Lane E AD - Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. FAU - Langholm, Carsten AU - Langholm C AD - Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. FAU - Lin, Eric AU - Lin E AD - Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA. AD - Medical Informatics Fellowship, Veteran Affairs Boston Healthcare System, Boston, MA, USA. AD - Food and Drug Administration, Silver Spring, MD, USA. FAU - Mantua, Valentina AU - Mantua V AD - Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA. FAU - Santorelli, Gennarina AU - Santorelli G AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. FAU - Ruparel, Kosha AU - Ruparel K AD - Department of Psychology, Yale University, New Haven, CT, USA. FAU - Zoupou, Eirini AU - Zoupou E AD - Department of Psychology, Yale University, New Haven, CT, USA. FAU - Adasme, Tatiana AU - Adasme T AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Addamo, Lauren AU - Addamo L AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Adery, Laura AU - Adery L AD - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Ali, Munaza AU - Ali M AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Auther, Andrea AU - Auther A AD - Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. FAU - Aversa, Samantha AU - Aversa S AD - PEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada. FAU - Baek, Seon-Hwa AU - Baek SH AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. AD - Mindlink, Gwangju Bukgu Mental Health Center, Gwangju, Korea. FAU - Bates, Kelly AU - Bates K AD - Department of Psychology, Northwestern University, Evanston, IL, USA. FAU - Bathery, Alyssa AU - Bathery A AD - Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA. FAU - Bayer, Johanna M M AU - Bayer JMM AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Beedham, Rebecca AU - Beedham R AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Bilgrami, Zarina AU - Bilgrami Z AD - Department of Psychology, Emory University, Atlanta, GA, USA. FAU - Birch, Sonia AU - Birch S AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Bonoldi, Ilaria AU - Bonoldi I AD - Department of Psychosis Studies, King's College London, London, UK. AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. FAU - Borders, Owen AU - Borders O AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Borgatti, Renato AU - Borgatti R AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. AD - IRCCS Mondino Foundation, Pavia, Italy. FAU - Brown, Lisa AU - Brown L AD - Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. FAU - Bruna, Alejandro AU - Bruna A AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Carrington, Holly AU - Carrington H AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Castillo-Passi, Rolando I AU - Castillo-Passi RI AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. AD - Department of Neurology and Psychiatry, Clinica Alemana-Universidad del Desarrollo, Santiago, Chile. FAU - Chen, Justine AU - Chen J AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Cheng, Nicholas AU - Cheng N AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Ching, Ann Ee AU - Ching AE AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Clifford, Chloe AU - Clifford C AD - School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK. FAU - Colton, Beau-Luke AU - Colton BL AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Contreras, Pamela AU - Contreras P AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Corral, Sebastian AU - Corral S AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Damiani, Stefano AU - Damiani S AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. FAU - Done, Monica AU - Done M AD - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Estrade, Andres AU - Estrade A AD - Early Psychosis Detection and Clinical Intervention (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK. FAU - Etuka, Brandon Asika AU - Etuka BA AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. FAU - Formica, Melanie AU - Formica M AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Furlan, Rachel AU - Furlan R AD - Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. FAU - Geljic, Mia AU - Geljic M AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Germano, Carmela AU - Germano C AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Getachew, Ruth AU - Getachew R AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Goncalves, Mathias AU - Goncalves M AD - Department of Psychology, Stanford University, Stanford, CA, USA. FAU - Haidar, Anastasia AU - Haidar A AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Hartmann, Jessica AU - Hartmann J AD - Department of Public Mental Health, Central Institute of Mental Health, Heidelberg Univeristy, Mannheim, Germany. FAU - Jo, Anna AU - Jo A AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. FAU - John, Omar AU - John O AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Kerins, Sarah AU - Kerins S AD - Early Psychosis Detection and Clinical Intervention (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK. FAU - Kerr, Melissa AU - Kerr M AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Kesselring, Irena AU - Kesselring I AD - Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA. FAU - Kim, Honey AU - Kim H AD - Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. FAU - Kim, Nicholas AU - Kim N AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Kinney, Kyle AU - Kinney K AD - Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. FAU - Krcmar, Marija AU - Krcmar M AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Kotler, Elana AU - Kotler E AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Lafanechere, Melanie AU - Lafanechere M AD - School of Psychology, University of Birmingham, Edgbaston, UK. AD - Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK. FAU - Lee, Clarice AU - Lee C AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Llerena, Joshua AU - Llerena J AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Markiewicz, Christopher AU - Markiewicz C AD - Department of Psychology, Stanford University, Stanford, CA, USA. FAU - Matnejl, Priya AU - Matnejl P AD - Northwell Health, Glen Oaks, NY, USA. FAU - Maturana, Alejandro AU - Maturana A AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Mavambu, Aissata AU - Mavambu A AD - School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK. FAU - Mayol-Troncoso, Rocio AU - Mayol-Troncoso R AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - McDonnell, Amelia AU - McDonnell A AD - Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. FAU - McGowan, Alessia AU - McGowan A AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - McLaughlin, Danielle AU - McLaughlin D AD - Northwell Health, Glen Oaks, NY, USA. FAU - McIlhenny, Rebecca AU - McIlhenny R AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - McQueen, Brittany AU - McQueen B AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Mebrahtu, Yohannes AU - Mebrahtu Y AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Mensi, Martina AU - Mensi M AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. AD - IRCCS Mondino Foundation, Pavia, Italy. FAU - Hui, Christy Lai Ming AU - Hui CLM AD - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong. FAU - Suen, Yi Nam AU - Suen YN AD - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong. FAU - Wong, Stephanie Ming Yin AU - Wong SMY AD - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong. FAU - Morrell, Neal AU - Morrell N AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Omar, Mariam AU - Omar M AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Partridge, Alice AU - Partridge A AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Phassouliotis, Christina AU - Phassouliotis C AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Pichiecchio, Anna AU - Pichiecchio A AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. AD - Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy. FAU - Politi, Pierluigi AU - Politi P AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. FAU - Porter, Christian AU - Porter C AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Provenzani, Umberto AU - Provenzani U AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. FAU - Prunier, Nicholas AU - Prunier N AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Raj, Jasmine AU - Raj J AD - Department of Psychology, Northwestern University, Evanston, IL, USA. FAU - Ray, Susan AU - Ray S AD - Northwell Health, Glen Oaks, NY, USA. FAU - Rayner, Victoria AU - Rayner V AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Reyes, Manuel AU - Reyes M AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. AD - Department of Neurology and Psychiatry, Clinica Alemana-Universidad del Desarrollo, Santiago, Chile. FAU - Reynolds, Kate AU - Reynolds K AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Rush, Sage AU - Rush S AD - Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA. FAU - Salinas, Cesar AU - Salinas C AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Shetty, Jashmina AU - Shetty J AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Snowball, Callum AU - Snowball C AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Tod, Sophie AU - Tod S AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Turra-Farina, Gabriel AU - Turra-Farina G AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Valle, Daniela AU - Valle D AD - Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. FAU - Veale, Simone AU - Veale S AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Whitson, Sarah AU - Whitson S AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Wickham, Alana AU - Wickham A AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. FAU - Youn, Sarah AU - Youn S AD - Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. AD - Orygen, Parkville, VIC, Australia. FAU - Zamorano, Francisco AU - Zamorano F AD - Unidad de imagenes cuantitativas avanzadas, departamento de imagenes, clinica alemana, universidad del Desarrollo, Santiago, Chile. AD - Facultad de ciencias para el cuidado de la salud, Universidad San Sebastian, Campus Los Leones, Santiago, Chile. FAU - Zavaglia, Elissa AU - Zavaglia E AD - PEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada. FAU - Zinberg, Jamie AU - Zinberg J AD - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. AD - Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Woods, Scott W AU - Woods SW AD - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. AD - Connecticut Mental Health Center, New Haven, CT, USA. FAU - Shenton, Martha E AU - Shenton ME AD - Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. AD - Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. AD - Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. LA - eng GR - U24 MH124629/MH/NIMH NIH HHS/United States GR - P50 HD103573/HD/NICHD NIH HHS/United States GR - WT_/Wellcome Trust/United Kingdom GR - U01 MH124631/MH/NIMH NIH HHS/United States GR - U01 MH124639/MH/NIMH NIH HHS/United States GR - MR/S037675/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Schizophr Bull JT - Schizophrenia bulletin JID - 0236760 SB - IM MH - Humans MH - *Psychotic Disorders MH - *Schizophrenia MH - Prospective Studies MH - Adult MH - Prodromal Symptoms MH - Young Adult MH - International Cooperation MH - Adolescent MH - Research Design/standards MH - Male MH - Female PMC - PMC11059785 OTO - NOTNLM OT - clinical high risk OT - consortium OT - early detection OT - prediction OT - prevention OT - psychosis EDAT- 2024/03/07 12:42 MHDA- 2024/04/30 13:42 PMCR- 2024/03/07 CRDT- 2024/03/07 11:06 PHST- 2024/04/30 13:42 [medline] PHST- 2024/03/07 12:42 [pubmed] PHST- 2024/03/07 11:06 [entrez] PHST- 2024/03/07 00:00 [pmc-release] AID - 7623752 [pii] AID - sbae011 [pii] AID - 10.1093/schbul/sbae011 [doi] PST - ppublish SO - Schizophr Bull. 2024 Apr 30;50(3):496-512. doi: 10.1093/schbul/sbae011.