PMID- 38451608
OWN - NLM
STAT- MEDLINE
DCOM- 20240308
LR  - 20240309
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 57
DP  - 2024
TI  - Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and 
      myocardial ischemia responses of patients with HFpEF or HFmrEF.
PG  - e13174
LID - S0100-879X2024000100617 [pii]
LID - 10.1590/1414-431X2024e13174 [doi]
LID - e13174
AB  - There's limited evidence of the potential benefits of cardiopulmonary and 
      metabolic rehabilitation (CPMR) in patients with heart failure with preserved 
      ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and 
      coronary artery disease (CAD). The aim of this study was to investigate the 
      impact of CPMR on the myocardial ischemia response (MIR), exercise-induced 
      arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate 
      recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical and mental 
      health summary scores. A prospective cohort study was conducted with 106 patients 
      undergoing 12 weeks of CPMR who completed two exercise tests pre- and post-CPMR: 
      1) maximum incremental test (CPX) and 2) submaximal constant load test (SUB). 
      After CPMR, the effects on MIR, EIA, NYHA functional class, and HRR during both 
      tests were analyzed. There was a significant change in NYHA functional classes 
      after CPMR, with 96% of the patients in class I (vs 62% pre-CPMR, P<0.0001), 4% 
      in class II (vs 32%), and none in class III (vs 6%). There was a significant 
      reduction in the frequency of EIA (P<0.05) and MIR (P<0.001) and a significantly 
      improved performance on both CPX and SUB tests (P<0.0001). Lastly, there was 
      significant progress in the recovery metrics like HRR (P<0.0001), the Borg CR10 
      (P<0.0001), and the SF-36 summary scores (P<0.0001). The CPMR resulted in a 
      significant decrease in EIA, delayed ischemia threshold in CPX and SUB tests, 
      increased functional capacity, and improved quality of life.
FAU - Hossri, C A C
AU  - Hossri CAC
AUID- ORCID: 0000-0002-2023-1143
AD  - Hospital do Coracao, Associacao Beneficente Siria, Sao Paulo, SP, Brasil.
AD  - Pneumologia-Incor, Instituto do Coracao, Hospital das Clinicas (HCFMUSP), 
      Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Araujo, F C
AU  - Araujo FC
AUID- ORCID: 0000-0002-8384-0480
AD  - FCA Sports, Belo Horizonte, MG, Brasil.
FAU - Baldi, B G
AU  - Baldi BG
AUID- ORCID: 0000-0002-9609-5117
AD  - Hospital do Coracao, Associacao Beneficente Siria, Sao Paulo, SP, Brasil.
AD  - Pneumologia-Incor, Instituto do Coracao, Hospital das Clinicas (HCFMUSP), 
      Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Otterstetter, R
AU  - Otterstetter R
AUID- ORCID: 0000-0001-8509-7259
AD  - School of Exercise and Nutrition Sciences, University of Akron, Akron, OH, USA.
FAU - Uemoto, V R
AU  - Uemoto VR
AUID- ORCID: 0000-0002-9629-4298
AD  - Setor da Bioengenharia, Instituto Dante Pazzanese, Sao Paulo, SP, Brasil.
FAU - Carvalho, C R R
AU  - Carvalho CRR
AUID- ORCID: 0000-0002-1618-8509
AD  - Hospital do Coracao, Associacao Beneficente Siria, Sao Paulo, SP, Brasil.
AD  - Pneumologia-Incor, Instituto do Coracao, Hospital das Clinicas (HCFMUSP), 
      Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
FAU - Mastrocola, L E
AU  - Mastrocola LE
AUID- ORCID: 0000-0002-4632-4540
AD  - Hospital do Coracao, Associacao Beneficente Siria, Sao Paulo, SP, Brasil.
FAU - Albuquerque, A L P
AU  - Albuquerque ALP
AUID- ORCID: 0000-0003-3486-5240
AD  - Hospital do Coracao, Associacao Beneficente Siria, Sao Paulo, SP, Brasil.
AD  - Pneumologia-Incor, Instituto do Coracao, Hospital das Clinicas (HCFMUSP), 
      Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20240304
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
SB  - IM
MH  - Humans
MH  - *Coronary Artery Disease
MH  - *Heart Failure
MH  - Prospective Studies
MH  - Quality of Life
MH  - Stroke Volume
MH  - *Myocardial Ischemia
MH  - Arrhythmias, Cardiac/etiology
PMC - PMC10913385
EDAT- 2024/03/07 12:42
MHDA- 2024/03/08 06:43
PMCR- 2024/03/04
CRDT- 2024/03/07 11:54
PHST- 2023/10/28 00:00 [received]
PHST- 2024/02/01 00:00 [accepted]
PHST- 2024/03/08 06:43 [medline]
PHST- 2024/03/07 12:42 [pubmed]
PHST- 2024/03/07 11:54 [entrez]
PHST- 2024/03/04 00:00 [pmc-release]
AID - S0100-879X2024000100617 [pii]
AID - 10.1590/1414-431X2024e13174 [doi]
PST - epublish
SO  - Braz J Med Biol Res. 2024 Mar 4;57:e13174. doi: 10.1590/1414-431X2024e13174. 
      eCollection 2024.