PMID- 38452967
OWN - NLM
STAT- MEDLINE
DCOM- 20240401
LR  - 20240404
IS  - 1096-0384 (Electronic)
IS  - 0003-9861 (Linking)
VI  - 754
DP  - 2024 Apr
TI  - The crucial role of NRF2 in erythropoiesis and anemia: Mechanisms and therapeutic 
      opportunities.
PG  - 109948
LID - S0003-9861(24)00067-5 [pii]
LID - 10.1016/j.abb.2024.109948 [doi]
AB  - The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor 
      crucial in cellular defense against oxidative and electrophilic stresses. Recent 
      research has highlighted the significance of NRF2 in normal erythropoiesis and 
      anemia. NRF2 regulates genes involved in vital aspects of erythroid development, 
      including hemoglobin catabolism, inflammation, and iron homeostasis in 
      erythrocytes. Disrupted NRF2 activity has been implicated in various pathologies 
      involving abnormal erythropoiesis. In this review, we summarize the progress made 
      in understanding the mechanisms of NRF2 activation in erythropoiesis and explore 
      the roles of NRF2 in various types of anemia. This review also discusses the 
      potential of targeting NRF2 as a new therapeutic approach to treat anemia.
CI  - Copyright (c) 2024 Elsevier Inc. All rights reserved.
FAU - Yang, Lei
AU  - Yang L
AD  - Institute of Translational Medicine, Medical College, Yangzhou University, 
      Yangzhou, 225009, China.
FAU - Chen, Yong
AU  - Chen Y
AD  - Department of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou 
      University, Yangzhou, Jiangsu, 225003, China.
FAU - He, Sheng
AU  - He S
AD  - Guangxi Key Laboratory of Birth Defects Research and Prevention, Guangxi Key 
      Laboratory of Reproductive Health and Birth Defects Prevention, Guangxi Zhuang 
      Autonomous Region Women and Children Care Hospital, Nanning, Guangxi, 530000, 
      China.
FAU - Yu, Duonan
AU  - Yu D
AD  - Department of Hematology, Sichuan Provincial People's Hospital, University of 
      Electronic Science and Technology of China, Chengdu, Sichuan, 610000, China; 
      Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, 
      Yangzhou University, Yangzhou, 225009, China; Guangxi Key Laboratory of Birth 
      Defects Research and Prevention, Guangxi Key Laboratory of Reproductive Health 
      and Birth Defects Prevention, Guangxi Zhuang Autonomous Region Women and Children 
      Care Hospital, Nanning, Guangxi, 530000, China. Electronic address: 
      dnyu@yzu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240305
PL  - United States
TA  - Arch Biochem Biophys
JT  - Archives of biochemistry and biophysics
JID - 0372430
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
SB  - IM
MH  - Humans
MH  - *Anemia/drug therapy/metabolism
MH  - *Erythropoiesis
MH  - Gene Expression Regulation
MH  - Inflammation
MH  - *NF-E2-Related Factor 2/metabolism
OTO - NOTNLM
OT  - Anemia
OT  - Erythroid development
OT  - NRF2
OT  - Stress erythropoiesis
COIS- Declaration of competing interest The authors declare no competing interests.
EDAT- 2024/03/08 00:43
MHDA- 2024/04/01 06:42
CRDT- 2024/03/07 19:17
PHST- 2024/01/04 00:00 [received]
PHST- 2024/02/25 00:00 [revised]
PHST- 2024/02/27 00:00 [accepted]
PHST- 2024/04/01 06:42 [medline]
PHST- 2024/03/08 00:43 [pubmed]
PHST- 2024/03/07 19:17 [entrez]
AID - S0003-9861(24)00067-5 [pii]
AID - 10.1016/j.abb.2024.109948 [doi]
PST - ppublish
SO  - Arch Biochem Biophys. 2024 Apr;754:109948. doi: 10.1016/j.abb.2024.109948. Epub 
      2024 Mar 5.