PMID- 38453136
OWN - NLM
STAT- Publisher
LR  - 20240504
IS  - 1538-9375 (Electronic)
IS  - 1525-8610 (Linking)
DP  - 2024 Mar 4
TI  - Association between Age at Diagnosis of Hyperlipidemia and Subsequent Risk of 
      Dementia.
PG  - 104960
LID - S1525-8610(24)00085-9 [pii]
LID - 10.1016/j.jamda.2024.01.029 [doi]
AB  - OBJECTIVES: The relationship between age at diagnosis of hyperlipidemia and 
      dementia remains unclear. We examined whether younger age at diagnosis of 
      hyperlipidemia is associated with higher risk of subsequent dementia. DESIGN: A 
      longitudinal population-based study with a median follow-up of 12.8 years. 
      SETTING AND PARTICIPANTS: We analyzed data on a sample of 489,642 participants in 
      the United Kingdom. METHODS: This study was based on the UK Biobank. Information 
      on hyperlipidemia and dementia diagnoses was collected at baseline (2006-2010) 
      and follow-up [median = 12.8 years, interquartile range (IQR): 12.1-13.6 years]. 
      Propensity score matching method and Cox proportional hazards models were used to 
      assess the association between age at diagnosis of hyperlipidemia and dementia. 
      RESULTS: Among 489,642 participants (mean age: 56.9 +/- 8.1 years; female: 54.7%), 
      114,112 (23.3%) were diagnosed with hyperlipidemia. Younger age at diagnosis of 
      hyperlipidemia (per 10-year decrease) was significantly associated with higher 
      risks of all-cause dementia [hazard ratio (HR), 1.12; 95% CI, 1.07-1.18; P < 
      .001], Alzheimer's disease (AD) (HR, 1.22; 95% CI, 1.14-1.31; P < .001), and 
      vascular dementia (VD) (HR, 1.16; 95% CI, 1.05-1.27; P < .001). After propensity 
      score matching, patients with hyperlipidemia diagnosed before 50 years had the 
      highest HR for all-cause dementia (HR, 1.46; 95% CI, 1.15-1.86; P = .002), 
      followed by patients diagnosed between 50 and 69 years (HR, 1.21; 95% CI, 
      1.12-1.31; P < .001) and then patients diagnosed aged 70 years and older (HR, 
      0.94; 95% CI, 0.84-1.06; P = .302). Similar results were observed for AD and VD. 
      CONCLUSIONS AND IMPLICATIONS: A dose-response relationship between age at 
      hyperlipidemia diagnosis and risk of dementia was found in the longitudinal 
      cohort study, with younger age at diagnosis of hyperlipidemia being associated 
      with higher subsequent risk.
CI  - Copyright (c) 2024 AMDA - The Society for Post-Acute and Long-Term Care Medicine. 
      Published by Elsevier Inc. All rights reserved.
FAU - Pan, Yang
AU  - Pan Y
AD  - School of Nursing, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Beijing, China.
FAU - Liang, Jie
AU  - Liang J
AD  - School of Nursing, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Beijing, China.
FAU - Zhang, Wenya
AU  - Zhang W
AD  - School of Nursing, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Beijing, China.
FAU - Gao, Darui
AU  - Gao D
AD  - Peking University Clinical Research Institute, Peking University First Hospital, 
      Beijing, China.
FAU - Li, Chenglong
AU  - Li C
AD  - Peking University Clinical Research Institute, Peking University First Hospital, 
      Beijing, China.
FAU - Xie, Wuxiang
AU  - Xie W
AD  - Peking University Clinical Research Institute, Peking University First Hospital, 
      Beijing, China; Key Laboratory of Epidemiology of Major Diseases (Peking 
      University), Ministry of Education, Beijing, China. Electronic address: 
      xiewuxiang@hsc.pku.edu.cn.
FAU - Zheng, Fanfan
AU  - Zheng F
AD  - School of Nursing, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Beijing, China. Electronic address: zhengfanfan@nursing.pumc.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240304
PL  - United States
TA  - J Am Med Dir Assoc
JT  - Journal of the American Medical Directors Association
JID - 100893243
SB  - IM
OTO - NOTNLM
OT  - UK Biobank
OT  - age at diagnosis
OT  - dementia
OT  - hyperlipidemia
OT  - propensity score matching
EDAT- 2024/03/08 00:43
MHDA- 2024/03/08 00:43
CRDT- 2024/03/07 19:22
PHST- 2023/11/07 00:00 [received]
PHST- 2024/01/30 00:00 [revised]
PHST- 2024/01/30 00:00 [accepted]
PHST- 2024/03/08 00:43 [pubmed]
PHST- 2024/03/08 00:43 [medline]
PHST- 2024/03/07 19:22 [entrez]
AID - S1525-8610(24)00085-9 [pii]
AID - 10.1016/j.jamda.2024.01.029 [doi]
PST - aheadofprint
SO  - J Am Med Dir Assoc. 2024 Mar 4:104960. doi: 10.1016/j.jamda.2024.01.029.