PMID- 38453752
OWN - NLM
STAT- MEDLINE
DCOM- 20240329
LR  - 20240409
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Linking)
VI  - 242
IP  - 4
DP  - 2024 Apr
TI  - An acute bout of resistance exercise increases BDNF in hippocampus and restores 
      the long-term memory of insulin-resistant rats.
PG  - 901-912
LID - 10.1007/s00221-024-06795-x [doi]
AB  - A sedentary lifestyle, inadequate diet, and obesity are substantial risk factors 
      for Type 2 diabetes mellitus (T2DM) development. A major picture of T2DM is 
      insulin resistance (IR), which causes many impairments in brain physiology, such 
      as increased proinflammatory state and decreased brain-derived neurotrophic 
      factor (BDNF) concentration, hence reducing cognitive function. Physical exercise 
      is a non-pharmacological tool for managing T2DM/IR and its complications. Thus, 
      this study investigated the effects of IR induction and the acute effects of 
      resistance exercise (RE) on memory, neurotrophic, and inflammatory responses in 
      the hippocampus and prefrontal cortex of insulin-resistant rats. IR was induced 
      by a high-fat diet and fructose-rich beverage. Insulin-resistant rats performed 
      acute resistance exercise (IR.RE; vertical ladder climb at 50-100% of the maximum 
      load) or rest (IR.REST; 20 min). Cognitive parameters were assessed by novel 
      object recognition (NOR) tasks, and biochemical analyses were performed to assess 
      BDNF concentrations and inflammatory profile in the hippocampus and prefrontal 
      cortex. Insulin-resistant rats had 20% worse long-term memory (LTM) (p < 0.01) 
      and lower BDNF concentration in the hippocampus (-14.6%; p < 0.05) when compared 
      to non-insulin-resistant rats (CON). An acute bout of RE restored LTM (-9.7% pre 
      vs. post; p > 0.05) and increased BDNF concentration in the hippocampus (9.1%; 
      p < 0.05) of insulin-resistant rats compared to REST. Thus, an acute bout of RE 
      can attenuate the adverse effects of IR on memory and neurotrophic factors in 
      rats, representing a therapeutic tool to alleviate the IR impact on the brain.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Berbert-Gomes, Camila
AU  - Berbert-Gomes C
AUID- ORCID: 0009-0007-6776-2498
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de 
      Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil.
FAU - Ramos, Julia S
AU  - Ramos JS
AUID- ORCID: 0009-0002-5092-4757
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de 
      Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil.
FAU - Silveira-Rodrigues, Joao G
AU  - Silveira-Rodrigues JG
AUID- ORCID: 0000-0003-2646-5079
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de 
      Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil.
FAU - Leite, Daniel M M
AU  - Leite DMM
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de 
      Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil.
FAU - Melo, Bruno P
AU  - Melo BP
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de 
      Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil.
FAU - Soares, Danusa D
AU  - Soares DD
AUID- ORCID: 0000-0002-5705-8890
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais (Universidade Federal de 
      Minas Gerais -UFMG), Belo Horizonte, MG, 31270‑901, Brazil. danusa56@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240307
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Rats
MH  - *Brain-Derived Neurotrophic Factor/metabolism
MH  - *Diabetes Mellitus, Type 2
MH  - Hippocampus/metabolism
MH  - Insulin
MH  - *Memory, Long-Term/physiology
MH  - *Resistance Training
OTO - NOTNLM
OT  - BDNF
OT  - Insulin resistance
OT  - Memory
OT  - Resistance exercise
EDAT- 2024/03/08 00:43
MHDA- 2024/03/29 06:45
CRDT- 2024/03/07 23:25
PHST- 2023/09/16 00:00 [received]
PHST- 2024/01/24 00:00 [accepted]
PHST- 2024/03/29 06:45 [medline]
PHST- 2024/03/08 00:43 [pubmed]
PHST- 2024/03/07 23:25 [entrez]
AID - 10.1007/s00221-024-06795-x [pii]
AID - 10.1007/s00221-024-06795-x [doi]
PST - ppublish
SO  - Exp Brain Res. 2024 Apr;242(4):901-912. doi: 10.1007/s00221-024-06795-x. Epub 
      2024 Mar 7.