PMID- 38454161
OWN - NLM
STAT- Publisher
LR  - 20240311
IS  - 1476-5489 (Electronic)
IS  - 0955-9930 (Linking)
DP  - 2024 Mar 7
TI  - Unveiling the molecular Hallmarks of Peyronie's disease: a comprehensive 
      narrative review.
LID - 10.1038/s41443-024-00845-2 [doi]
AB  - Peyronie's disease, a fibroinflammatory disorder, detrimentally impacts the 
      sexual well-being of men and their partners. The manifestation of fibrotic 
      plaques within penile tissue, attributed to dysregulated fibrogenesis, is 
      pathognomonic for this condition. The onset of fibrosis hinges on the 
      perturbation of the equilibrium between matrix metalloproteinases (MMPs), crucial 
      enzymes governing the extracellular matrix, and tissue inhibitors of MMPs 
      (TIMPs). In the context of Peyronie's disease, there is an elevation in TIMP 
      levels coupled with a decline in MMP levels, culminating in fibrogenesis. Despite 
      the scant molecular insights into fibrotic pathologies, particularly in the 
      context of Peyronie's disease, a comprehensive literature search spanning 1995 to 
      2023, utilizing PubMed Library, was conducted to elucidate these mechanisms. The 
      findings underscore the involvement of growth factors such as FGF and PDGF, and 
      cytokines like IL-1 and IL-6, alongside PAI-1, PTX-3, HIF, and IgG4 in the 
      fibrotic cascade. Given the tissue-specific modulation of fibrosis, comprehending 
      the molecular underpinnings of penile fibrosis becomes imperative for the 
      innovation of novel and efficacious therapies targeting Peyronie's disease. This 
      review stands as a valuable resource for researchers and clinicians engaged in 
      investigating the molecular basis of fibrotic diseases, offering guidance for 
      advancements in understanding Peyronie's disease.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Sahin, Ali
AU  - Sahin A
AUID- ORCID: 0000-0002-3139-8205
AD  - Selcuk University School of Medicine, 42250, Konya, Turkey.
FAU - Babayev, Huseyn
AU  - Babayev H
AD  - Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 
      7265, Davos, Switzerland.
FAU - Cirigliano, Lorenzo
AU  - Cirigliano L
AUID- ORCID: 0000-0002-8732-4272
AD  - Department of Urology, Molinette Hospital, University of Torino, AOU Citta della 
      Salute e della Scienza di Torino, Turin, Italy.
FAU - Preto, Mirko
AU  - Preto M
AUID- ORCID: 0000-0002-8144-6498
AD  - Department of Urology, Molinette Hospital, University of Torino, AOU Citta della 
      Salute e della Scienza di Torino, Turin, Italy.
FAU - Falcone, Marco
AU  - Falcone M
AUID- ORCID: 0000-0003-1101-892X
AD  - Department of Urology, Molinette Hospital, University of Torino, AOU Citta della 
      Salute e della Scienza di Torino, Turin, Italy.
FAU - Altintas, Emre
AU  - Altintas E
AUID- ORCID: 0000-0002-6797-3937
AD  - Department of Urology, Selcuk University School of Medicine, 42250, Konya, 
      Turkey.
FAU - Gul, Murat
AU  - Gul M
AUID- ORCID: 0000-0002-6657-6227
AD  - Department of Urology, Molinette Hospital, University of Torino, AOU Citta della 
      Salute e della Scienza di Torino, Turin, Italy. drmuratgul@hotmail.com.
AD  - Department of Urology, Selcuk University School of Medicine, 42250, Konya, 
      Turkey. drmuratgul@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240307
PL  - England
TA  - Int J Impot Res
JT  - International journal of impotence research
JID - 9007383
SB  - IM
EDAT- 2024/03/08 00:43
MHDA- 2024/03/08 00:43
CRDT- 2024/03/07 23:50
PHST- 2023/10/11 00:00 [received]
PHST- 2024/02/12 00:00 [accepted]
PHST- 2024/01/26 00:00 [revised]
PHST- 2024/03/08 00:43 [pubmed]
PHST- 2024/03/08 00:43 [medline]
PHST- 2024/03/07 23:50 [entrez]
AID - 10.1038/s41443-024-00845-2 [pii]
AID - 10.1038/s41443-024-00845-2 [doi]
PST - aheadofprint
SO  - Int J Impot Res. 2024 Mar 7. doi: 10.1038/s41443-024-00845-2.