PMID- 38454483
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240310
IS  - 1749-8546 (Print)
IS  - 1749-8546 (Electronic)
IS  - 1749-8546 (Linking)
VI  - 19
IP  - 1
DP  - 2024 Mar 7
TI  - A multi-center cross-sectional study of Chinese Herbal Medicine-Drug adverse 
      reactions using active surveillance in Singapore's Traditional Chinese Medicine 
      clinics.
PG  - 44
LID - 10.1186/s13020-024-00915-z [doi]
LID - 44
AB  - BACKGROUND: This study aimed to investigate the rates and causality of 
      patient-reported adverse events (AEs) associated with concomitant Chinese Herbal 
      Medicine (CHM) and Western Medicine prescription drug (WMPD) consumption through 
      active surveillance in Singapore's Traditional Chinese Medicine (TCM) clinics. 
      METHODS: A cross-sectional study was conducted at five TCM clinics across 
      Singapore from 8th May till 8th July 2023. Patients were screened to determine 
      rates of CHM and WMPD consumption, and then interviewed if an AE was reported. An 
      expert committee assessed the AE reports to determine causality. Along with 
      descriptive statistics, odds ratios were calculated to determine AE occurrence 
      likelihoods for patients who consumed both CHM and WMPD compared to CHM 
      consumption alone. RESULTS: 1028 patients were screened and 62.65% of them 
      reported concurrent CHM-WMPD consumption. Patients who consumed CHM and WMPD were 
      3.65 times more likely to experience an AE as compared to CHM consumption alone. 
      18 AE reports were adjudicated, with most AEs deemed unlikely due to CHM 
      consumption. CONCLUSIONS: A large proportion of patients consumed CHM and WMPD 
      concurrently, thus increasing their risk of experiencing AEs compared to those 
      consuming CHM only. Active surveillance is applicable for detecting AEs, 
      collecting data for causality assessment, and analysis.
CI  - (c) 2024. The Author(s).
FAU - Ng, Chester Yan Jie
AU  - Ng CYJ
AD  - School of Biological Sciences, Nanyang Technological University, 60 Nanyang 
      Drive, Singapore, 637551, Singapore.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - School of Biological Sciences, Nanyang Technological University, 60 Nanyang 
      Drive, Singapore, 637551, Singapore.
FAU - Wang, Ning
AU  - Wang N
AD  - School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of 
      Hong Kong, Hong Kong, Hong Kong.
FAU - Chia, Kwan Leung
AU  - Chia KL
AD  - Woodcroft Medical Centre, 1 Sir James Hardy Way, Woodcroft, SA, 5162, Australia.
FAU - Teo, Chun Huat
AU  - Teo CH
AD  - Singapore Thong Chai Medical Institution, 50 Chin Swee Road #01-01, Singapore, 
      169874, Singapore.
FAU - Peh, William
AU  - Peh W
AD  - Operation and Medical Department, Singapore Chung Hwa Medical Institution, 640 
      Lorong 4 Toa Payoh, Singapore, 319522, Singapore.
FAU - Yeo, Pansy
AU  - Yeo P
AD  - Chong Hoe Healthcare, 144 Upper Bukit Timah Rd, #02-14, Singapore, 588177*, 
      Singapore.
FAU - Zhong, Linda L D
AU  - Zhong LLD
AD  - School of Biological Sciences, Nanyang Technological University, 60 Nanyang 
      Drive, Singapore, 637551, Singapore. linda.zhong@ntu.edu.sg.
LA  - eng
GR  - SCM-2020-001/Qi Huang Young Scholar Programme/
PT  - Journal Article
DEP - 20240307
PL  - England
TA  - Chin Med
JT  - Chinese medicine
JID - 101265109
PMC - PMC10918936
OTO - NOTNLM
OT  - Active Surveillance
OT  - Adverse Events
OT  - Drugs
OT  - Epidemiology
OT  - Traditional Chinese Medicine
COIS- The authors declare that they have no competing interests.
EDAT- 2024/03/08 06:42
MHDA- 2024/03/08 06:43
PMCR- 2024/03/07
CRDT- 2024/03/08 00:41
PHST- 2023/09/26 00:00 [received]
PHST- 2024/02/27 00:00 [accepted]
PHST- 2024/03/08 06:43 [medline]
PHST- 2024/03/08 06:42 [pubmed]
PHST- 2024/03/08 00:41 [entrez]
PHST- 2024/03/07 00:00 [pmc-release]
AID - 10.1186/s13020-024-00915-z [pii]
AID - 915 [pii]
AID - 10.1186/s13020-024-00915-z [doi]
PST - epublish
SO  - Chin Med. 2024 Mar 7;19(1):44. doi: 10.1186/s13020-024-00915-z.