PMID- 38455215
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240309
IS  - 2048-7177 (Print)
IS  - 2048-7177 (Electronic)
IS  - 2048-7177 (Linking)
VI  - 12
IP  - 3
DP  - 2024 Mar
TI  - Inulin-type fructans with different degrees of polymerization improve insulin 
      resistance, metabolic parameters, and hormonal status in overweight and obese 
      women with polycystic ovary syndrome: A randomized double-blind, 
      placebo-controlled clinical trial.
PG  - 2016-2028
LID - 10.1002/fsn3.3899 [doi]
AB  - Polycystic ovary syndrome (PCOS) is associated with reproductive disorders and 
      adverse cardiometabolic risk factors that can negatively impact the general 
      health of women. Inulin-type fructans (ITFs) are proposed to beneficially affect 
      risk factors associated with metabolic disorders. Whether ITFs can help with the 
      management of PCOS by modifying insulin resistance (IR) and androgen levels has 
      not yet been explored. The aim of this study was to investigate the effects of 
      ITFs with different degrees of polymerization on insulin resistance, blood 
      lipids, anthropometric measures, and hormonal status in overweight and obese 
      women with PCOS. In a randomized double-blind placebo-controlled trial, 
      seventy-five women with PCOS aged 18-40 years old were randomly assigned to 
      receive 10 g/day of high-performance inulin (HPI) or oligofructose-enriched 
      inulin (OEI) or maltodextrin for 12 weeks. Biochemical and clinical outcomes were 
      measured at baseline and after the intervention. Participants in the HPI and OEI 
      groups experienced improvements in waist circumference, total testosterone, free 
      androgen index, sex hormone-binding globulin, and triglycerides compared to the 
      placebo group. Also, the number of women with irregular menses or oligomenorrhoea 
      decreased significantly in both ITF groups. Participants in the HPI group 
      reported lower body mass, fasting insulin, and HOMA-IR, as well as a higher 
      quantitative insulin sensitivity check index. ITF supplementation, especially 
      with long-chain ITFs, when given for 12 weeks may improve metabolic outcomes, 
      androgen status and clinical manifestations in women with PCOS.
CI  - (c) 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
FAU - Ziaei, Rahele
AU  - Ziaei R
AUID- ORCID: 0000-0002-9771-4936
AD  - Department of Community Nutrition, School of Nutrition and Food Science Isfahan 
      University of Medical Sciences Isfahan Iran.
FAU - Shahshahan, Zahra
AU  - Shahshahan Z
AD  - Department of Obstetrics and Gynecology, School of Medicine Isfahan University of 
      Medical Sciences Isfahan Iran.
FAU - Ghasemi-Tehrani, Hatav
AU  - Ghasemi-Tehrani H
AD  - Fertility Department, School of Medicine Isfahan University of Medical Sciences 
      Isfahan Iran.
FAU - Heidari, Zahra
AU  - Heidari Z
AD  - Department of Biostatistics and Epidemiology, School of Health Isfahan University 
      of Medical Sciences Isfahan Iran.
FAU - Nehls, Marilyn S
AU  - Nehls MS
AD  - Department of Kinesiology and Health Promotion University of Kentucky Lexington 
      Kentucky USA.
FAU - Ghiasvand, Reza
AU  - Ghiasvand R
AUID- ORCID: 0000-0002-0755-2575
AD  - Department of Community Nutrition, School of Nutrition and Food Science Isfahan 
      University of Medical Sciences Isfahan Iran.
LA  - eng
PT  - Journal Article
DEP - 20231226
PL  - United States
TA  - Food Sci Nutr
JT  - Food science & nutrition
JID - 101605473
PMC - PMC10916604
OTO - NOTNLM
OT  - insulin
OT  - inulin
OT  - microbiota
OT  - obese
OT  - polycystic ovary syndrome
OT  - prebiotics
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/08 06:43
MHDA- 2024/03/08 06:44
PMCR- 2023/12/26
CRDT- 2024/03/08 03:57
PHST- 2023/03/13 00:00 [received]
PHST- 2023/11/23 00:00 [revised]
PHST- 2023/11/25 00:00 [accepted]
PHST- 2024/03/08 06:44 [medline]
PHST- 2024/03/08 06:43 [pubmed]
PHST- 2024/03/08 03:57 [entrez]
PHST- 2023/12/26 00:00 [pmc-release]
AID - FSN33899 [pii]
AID - 10.1002/fsn3.3899 [doi]
PST - epublish
SO  - Food Sci Nutr. 2023 Dec 26;12(3):2016-2028. doi: 10.1002/fsn3.3899. eCollection 
      2024 Mar.