PMID- 38455654
OWN - NLM
STAT- MEDLINE
DCOM- 20240311
LR  - 20240311
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 15
DP  - 2024
TI  - The role of adiponectin in the association between abdominal obesity and type 2 
      diabetes: a mediation analysis among 232,438 Chinese participants.
PG  - 1327716
LID - 10.3389/fendo.2024.1327716 [doi]
LID - 1327716
AB  - BACKGROUND: Adiposity and adipokines are closely associated with obesity-related 
      metabolic abnormalities, but little is known regarding whether abdominal obesity 
      is linked to type 2 diabetes mellitus (T2DM) through circulating adiponectin 
      levels. Thus, this large-population-based study was designed to investigate the 
      mediating effect of adiponectin in the relationship between abdominal obesity and 
      T2DM. METHODS: A total of 232,438 adults who lived in Dongguan, Guangdong 
      Province, China, were enrolled in the present study. The circulating adiponectin 
      concentrations were measured using latex-enhanced immunoturbidimetric assay. The 
      association between circulating adiponectin and other clinical parameters was 
      detected by Spearman's correlation analysis. Restricted cubic spline (RCS) 
      regression was also used to address the non-linearity of the relationship between 
      waist circumference and diabetes. Mediation analyses of circulating adiponectin 
      were conducted using linear and logistic regression. RESULTS: Subjects with 
      abdominal obesity had lower levels of circulating adiponectin (P < 0.001). The 
      circulating adiponectin value was inversely related to BMI (r = -0.370, P < 
      0.001), waist circumference (r = -0.361, P < 0.001), and fasting plasma glucose 
      (r = -0.221, P < 0.001). The RCS plot showed a non-linear relation linking waist 
      circumference with T2DM (P for non-linearity < 0.001). Patients with abdominal 
      obesity presented 2.062 times higher odds of T2DM in comparison with those with 
      non-abdominal obesity (odds ratio, 2.062; 95% confidence interval, 1.969-2.161) 
      after adjusting for confounders. In the mediation analyses, the circulating 
      adiponectin mediated the association between abdominal obesity and T2DM, with a 
      mediation effect of 41.02% after adjustments. The above results were consistent 
      in both men and women. CONCLUSION: The relationship between abdominal obesity and 
      T2DM is mediated through circulating adiponectin level in adults, suggesting that 
      circulating adiponectin might be a potential predictor for controlling the 
      adverse progression from adiposity to T2DM.
CI  - Copyright (c) 2024 He, Xuan, Liu, Zhong, Luo, Cui, Zhang and Chen.
FAU - He, Lingjie
AU  - He L
AD  - Department of Endocrinology, The Tenth Affiliated Hospital, Southern Medical 
      University (Dongguan People's Hospital), Dongguan, China.
FAU - Xuan, Wenting
AU  - Xuan W
AD  - Department of Endocrinology, The Tenth Affiliated Hospital, Southern Medical 
      University (Dongguan People's Hospital), Dongguan, China.
FAU - Liu, Dixing
AU  - Liu D
AD  - Department of Endocrinology, The Tenth Affiliated Hospital, Southern Medical 
      University (Dongguan People's Hospital), Dongguan, China.
FAU - Zhong, Jiana
AU  - Zhong J
AD  - Department of Endocrinology, Dongguan Affiliated Hospital of Jinan University, 
      Binhaiwan Central Hospital of Dongguan, Dongguan, China.
FAU - Luo, Huijin
AU  - Luo H
AD  - Department of Endocrinology, The Tenth Affiliated Hospital, Southern Medical 
      University (Dongguan People's Hospital), Dongguan, China.
FAU - Cui, Han
AU  - Cui H
AD  - Department of Endocrinology, The Tenth Affiliated Hospital, Southern Medical 
      University (Dongguan People's Hospital), Dongguan, China.
FAU - Zhang, Xiuwei
AU  - Zhang X
AD  - Department of Endocrinology, The Tenth Affiliated Hospital, Southern Medical 
      University (Dongguan People's Hospital), Dongguan, China.
FAU - Chen, Weikun
AU  - Chen W
AD  - Department of Endocrinology, The Tenth Affiliated Hospital, Southern Medical 
      University (Dongguan People's Hospital), Dongguan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240222
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Adiponectin)
SB  - IM
MH  - Male
MH  - Adult
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Obesity, Abdominal/complications/epidemiology
MH  - Adiponectin
MH  - Mediation Analysis
MH  - Obesity/complications
PMC - PMC10919146
OTO - NOTNLM
OT  - abdominal obesity
OT  - adiponectin
OT  - adiposity
OT  - mediation analysis
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/03/08 06:42
MHDA- 2024/03/11 06:43
PMCR- 2024/01/01
CRDT- 2024/03/08 04:02
PHST- 2023/10/25 00:00 [received]
PHST- 2024/01/30 00:00 [accepted]
PHST- 2024/03/11 06:43 [medline]
PHST- 2024/03/08 06:42 [pubmed]
PHST- 2024/03/08 04:02 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2024.1327716 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2024 Feb 22;15:1327716. doi: 
      10.3389/fendo.2024.1327716. eCollection 2024.