PMID- 38456105
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240309
IS  - 1394-195X (Print)
IS  - 2180-4303 (Electronic)
IS  - 1394-195X (Linking)
VI  - 31
IP  - 1
DP  - 2024 Feb
TI  - Safety and Efficacy of High-Intensity Focused Ultrasound and Monopolar 
      Radiofrequency Combination Therapy for Skin Tightening: A Retrospective Study in 
      Malaysia.
PG  - 114-123
LID - 10.21315/mjms2024.31.1.10 [doi]
AB  - BACKGROUND: High-intensity focused ultrasound (HIFU) and monopolar radiofrequency 
      (MRF) are common treatment modalities that have shown significant results in skin 
      tightening. Nevertheless, the novel combination of these two treatments is new to 
      the Malaysian landscape. Thus, this study aims to investigate the safety and 
      efficacy of this novel combination treatment for the Malaysian population. 
      METHODS: This retrospective study included data on HIFU and MRF combination 
      therapy for skin tightening collected from an aesthetic clinic in Johor Bahru, 
      Malaysia from June 2018 to May 2021. Efficacy was assessed using the Global 
      Aesthetic Improvement Scale (GAIS) and Glogau classification, while the safety of 
      the treatment was analysed using pain scores and adverse events (AEs). RESULTS: A 
      total of 56 patients with a mean age of 47.7 years old (SD 10.00) were included 
      in this study. The majority of the patients had Fitzpatrick skin types III and 
      IV. Most of the patients were Chinese, followed by Malay, Indian and others. Most 
      patients (96.4%) showed clinically significant improvement in skin tightening 
      after treatment, with 15 patients scoring 1 (very much improved) and 39 scoring 2 
      (improved). All patients reported transient mild erythema, with no serious AEs, 
      such as burn, swelling, numbness or muscle weakness. Among the patients, 80% 
      reported a pain score of 5, while 10% reported pain scores of 4 and 6. 
      CONCLUSION: Combining HIFU with MRF therapy improved GAIS scores by 96.4%, 
      indicating a secure and efficient skin-tightening method. Transient erythema was 
      shown to be the most common side effect of this combination.
CI  - (c) Penerbit Universiti Sains Malaysia, 2024.
FAU - Khong, Sarah-Jane Mey Leong
AU  - Khong SML
AD  - Klinik Gayana, Selangor, Malaysia.
FAU - Ismail, Adibah Hanim
AU  - Ismail AH
AD  - Klinik Dr. Adibah, Negeri Sembilan, Malaysia.
FAU - Sujani, Suhaila
AU  - Sujani S
AD  - Zeyls Clinic, Johor, Malaysia.
FAU - Devindaran, Nithiyaa
AU  - Devindaran N
AD  - Klinik Medveon, Selangor, Malaysia.
FAU - Abdul Rashid, Muhammad Farhan
AU  - Abdul Rashid MF
AD  - USMARI Research and Innovation Centre, Selangor, Malaysia.
FAU - Mohd Zaman, Ungku Mohd Shahrin
AU  - Mohd Zaman UMS
AD  - USMARI Research and Innovation Centre, Selangor, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20240228
PL  - Malaysia
TA  - Malays J Med Sci
JT  - The Malaysian journal of medical sciences : MJMS
JID - 101126308
PMC - PMC10917599
OTO - NOTNLM
OT  - GAIS score
OT  - HIFU/MRF combination therapy
OT  - high-intensity focused ultrasound
OT  - monopolar radiofrequency
OT  - skin tightening
COIS- Conflict of Interest: None.
EDAT- 2024/03/08 06:43
MHDA- 2024/03/08 06:44
PMCR- 2024/02/01
CRDT- 2024/03/08 04:09
PHST- 2022/12/26 00:00 [received]
PHST- 2023/03/21 00:00 [accepted]
PHST- 2024/03/08 06:44 [medline]
PHST- 2024/03/08 06:43 [pubmed]
PHST- 2024/03/08 04:09 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
AID - 10mjms3101_oa [pii]
AID - 10.21315/mjms2024.31.1.10 [doi]
PST - ppublish
SO  - Malays J Med Sci. 2024 Feb;31(1):114-123. doi: 10.21315/mjms2024.31.1.10. Epub 
      2024 Feb 28.