PMID- 38457968
OWN - NLM
STAT- MEDLINE
DCOM- 20240409
LR  - 20240409
IS  - 1527-3288 (Electronic)
IS  - 0147-9563 (Linking)
VI  - 65
DP  - 2024 May-Jun
TI  - Association between carotenoids and the prevalence of chronic obstructive 
      pulmonary disease in the United States.
PG  - 93-100
LID - S0147-9563(24)00029-3 [pii]
LID - 10.1016/j.hrtlng.2024.02.010 [doi]
AB  - BACKGROUND: Previous studies mainly concentrated on examining the correlation 
      between single carotenoids and Chronic obstructive pulmonary disease (COPD). 
      However, these findings have been inconsistent. OBJECTIVES: This study aimed to 
      evaluate both the individual and overall associations of carotenoids with the 
      prevalence of COPD. METHODS: This study comprised 2,939 participants chosen from 
      the National Health and Nutrition Examination Survey (NHANES) 2017-2018. The 
      logistic regression, quantile-based G-computation regression (qgcomp), and 
      Bayesian kernel machine regression (BKMR) models were employed to explore the 
      association between carotenoids and the prevalence of COPD. Mediation analyses 
      were also conducted to explore the underlying mechanism of carotenoids on COPD. 
      RESULTS: Individuals diagnosed with COPD had significantly lower serum carotenoid 
      concentrations than those without COPD. We found a negative relationship between 
      combined carotenoids and the prevalence of COPD, and lutein and zeaxanthin and 
      alpha cryptoxanthin were identified as the main contributors to this negative 
      association. Moreover, eosinophil acted as a mediator in the relationship between 
      lutein and zeaxanthin, alpha cryptoxanthin, and the prevalence of COPD, with 
      mediating proportions of 2.75 % and 3.67 %. CONCLUSION: A negative association 
      was observed between combined carotenoids and COPD prevalence, with lutein and 
      zeaxanthin, and alpha cryptoxanthin identified as the main contributors. 
      Eosinophils could potentially mediate the association between carotenoids and 
      COPD.
CI  - Copyright (c) 2024. Published by Elsevier Inc.
FAU - Huang, Qiong
AU  - Huang Q
AD  - Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, 
      Central South University, Changsha 410008, China; Department of Geriatric 
      Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; 
      National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha 410008, China.
FAU - Peng, Zhenyu
AU  - Peng Z
AD  - Department of Emergency Medicine, Second Xiangya Hospital, Central South 
      University, Changsha 410011, China.
FAU - Li, Siqi
AU  - Li S
AD  - Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, 
      Central South University, Changsha 410008, China; Department of Geriatric 
      Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; 
      National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha 410008, China.
FAU - Nan, Wenbin
AU  - Nan W
AD  - Department of Emergency Medicine, Second Xiangya Hospital, Central South 
      University, Changsha 410011, China.
FAU - He, Baimei
AU  - He B
AD  - Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, 
      Central South University, Changsha 410008, China; Department of Geriatric 
      Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; 
      National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha 410008, China. Electronic address: 
      hebaimei@csu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240308
PL  - United States
TA  - Heart Lung
JT  - Heart & lung : the journal of critical care
JID - 0330057
RN  - 36-88-4 (Carotenoids)
RN  - X72A60C9MT (Lutein)
RN  - 0 (Zeaxanthins)
RN  - 0 (alpha-cryptoxanthin)
RN  - 0 (Cryptoxanthins)
SB  - IM
MH  - Humans
MH  - United States/epidemiology
MH  - *Carotenoids
MH  - Lutein
MH  - Nutrition Surveys
MH  - Zeaxanthins
MH  - Bayes Theorem
MH  - Prevalence
MH  - Cryptoxanthins
MH  - *Pulmonary Disease, Chronic Obstructive/epidemiology
OTO - NOTNLM
OT  - BKMR
OT  - COPD
OT  - Carotenoids
OT  - NHANES
OT  - Qgcomp
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2024/03/09 10:42
MHDA- 2024/04/09 06:45
CRDT- 2024/03/08 18:07
PHST- 2023/11/09 00:00 [received]
PHST- 2024/02/07 00:00 [revised]
PHST- 2024/02/27 00:00 [accepted]
PHST- 2024/04/09 06:45 [medline]
PHST- 2024/03/09 10:42 [pubmed]
PHST- 2024/03/08 18:07 [entrez]
AID - S0147-9563(24)00029-3 [pii]
AID - 10.1016/j.hrtlng.2024.02.010 [doi]
PST - ppublish
SO  - Heart Lung. 2024 May-Jun;65:93-100. doi: 10.1016/j.hrtlng.2024.02.010. Epub 2024 
      Mar 8.