PMID- 38458180
OWN - NLM
STAT- Publisher
LR  - 20240308
IS  - 1543-2742 (Electronic)
IS  - 1526-484X (Linking)
DP  - 2024 Mar 7
TI  - Trehalose Improved 20-min Cycling Time-Trial Performance After 100-min Cycling in 
      Amateur Cyclists.
PG  - 1-8
LID - 10.1123/ijsnem.2023-0241 [doi]
AB  - Carbohydrate (CHO) supplementation during endurance exercise can improve 
      performance. However, it is unclear whether low glycemic index (GI) CHO leads to 
      differential ergogenic and metabolic effects compared with a standard high GI 
      CHO. This study investigated the ergogenic and metabolic effects of CHO 
      supplementation with distinct GIs, namely, (a) trehalose (30 g/hr), 
      (b) isomaltulose (30 g/hr), (c) maltodextrin (60 g/hr), and (d) placebo (water). 
      In this double-blind, crossover, counterbalanced, placebo-controlled study, 13 
      male cyclists cycled a total of 100 min at varied exercise intensity 
      (i.e., 10-min stages at 1.5, 2.0, and 2.5 W/kg; repeated three times plus two 
      5-min stages at 1.0 W/kg before and after the protocol), followed by a 20-min 
      time trial on four separated occasions. Blood glucose and lactate (every 20 min), 
      heart rate, and ratings of perceived exertion were collected throughout, and 
      muscle biopsies were taken before and immediately after exercise. The results 
      showed that trehalose improved time-trial performance compared with placebo 
      (total work done 302 +/- 39 vs. 287 +/- 48 kJ; p = .01), with no other differences 
      between sessions (all p >/= .07). Throughout the 100-min protocol, blood glucose 
      was higher with maltodextrin compared with the other supplements at all time 
      points (all p < .05). Heart rate, ratings of perceived exertion, muscle glycogen 
      content, blood glucose, and lactate were not different between conditions when 
      considering the 20-min time trial (all p > .05). Trehalose supplementation 
      throughout endurance exercise improved cycling performance and appears to be an 
      appropriate CHO source for exercise tasks up to 2 hr. No ergogenic superiority 
      between the different types of CHO was established.
FAU - de Oliveira, Nathan Gobbi
AU  - de Oliveira NG
AUID- ORCID: 0000-0001-6800-4241
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - de Oliveira, Luana Farias
AU  - de Oliveira LF
AUID- ORCID: 0000-0001-8225-5784
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - da Silva, Rafael Pires
AU  - da Silva RP
AUID- ORCID: 0000-0003-0172-9840
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Oliveira, Tamires Nunes
AU  - Oliveira TN
AUID- ORCID: 0000-0001-6596-8707
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Moller, Gabriella Berwig
AU  - Moller GB
AUID- ORCID: 0000-0001-5354-0551
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Murasaki, Juliana
AU  - Murasaki J
AUID- ORCID: 0000-0002-8559-0569
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Ramires, Manoel Antonio
AU  - Ramires MA
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Azevedo, Rafael de Almeida
AU  - Azevedo RA
AUID- ORCID: 0000-0002-0346-7007
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Artioli, Guilherme Giannini
AU  - Artioli GG
AUID- ORCID: 0000-0001-8463-2213
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Roschel, Hamilton
AU  - Roschel H
AUID- ORCID: 0000-0002-9513-6132
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Gualano, Bruno
AU  - Gualano B
AUID- ORCID: 0000-0001-7100-8681
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
AD  - Food Research Center, University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Saunders, Bryan
AU  - Saunders B
AUID- ORCID: 0000-0003-0995-9077
AD  - Applied Physiology and Nutrition Research Group - Center of Lifestyle Medicine, 
      Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
AD  - Institute of Orthopaedics and Traumatology, Faculty of Medicine FMUSP, University 
      of Sao Paulo, Sao Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20240307
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
SB  - IM
OTO - NOTNLM
OT  - Palatinose
OT  - carbohydrate
OT  - endurance exercise
OT  - muscle glycogen
OT  - supplementation
EDAT- 2024/03/09 10:43
MHDA- 2024/03/09 10:43
CRDT- 2024/03/08 18:32
PHST- 2023/11/08 00:00 [received]
PHST- 2024/01/10 00:00 [revised]
PHST- 2024/01/30 00:00 [accepted]
PHST- 2024/03/09 10:43 [medline]
PHST- 2024/03/09 10:43 [pubmed]
PHST- 2024/03/08 18:32 [entrez]
AID - 10.1123/ijsnem.2023-0241 [doi]
PST - aheadofprint
SO  - Int J Sport Nutr Exerc Metab. 2024 Mar 7:1-8. doi: 10.1123/ijsnem.2023-0241.