PMID- 38459065
OWN - NLM
STAT- MEDLINE
DCOM- 20240311
LR  - 20240312
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Mar 8
TI  - The clinical relevance of a polygenic risk score for type 2 diabetes mellitus in 
      the Korean population.
PG  - 5749
LID - 10.1038/s41598-024-55313-0 [doi]
LID - 5749
AB  - The clinical utility of a type 2 diabetes mellitus (T2DM) polygenic risk score 
      (PRS) in the East Asian population remains underexplored. We aimed to examine the 
      potential prognostic value of a T2DM PRS and assess its viability as a clinical 
      instrument. We first established a T2DM PRS for 5490 Korean individuals using 
      East Asian Biobank data (269,487 samples). Subsequently, we assessed the 
      predictive capability of this T2DM PRS in a prospective longitudinal study with 
      baseline data and data from seven additional follow-ups. Our analysis showed that 
      the T2DM PRS could predict the transition of glucose tolerance stages from normal 
      glucose tolerance to prediabetes and from prediabetes to T2DM. Moreover, T2DM 
      patients in the top-decile PRS group were more likely to be treated with insulin 
      (hazard ratio = 1.69, p value = 2.31E-02) than were those in the remaining PRS 
      groups. T2DM PRS values were significantly high in the severe diabetes subgroup, 
      characterized by insulin resistance and beta -cell dysfunction (p value = 0.0012). 
      The prediction models with the T2DM PRS had significantly greater Harrel's 
      C-indices than did corresponding models without it. By utilizing prospective 
      longitudinal study data and extensive clinical risk factor information, our 
      analysis provides valuable insights into the multifaceted clinical utility of the 
      T2DM PRS.
CI  - (c) 2024. The Author(s).
FAU - Kim, Na Yeon
AU  - Kim NY
AD  - Graduate School of Data Science, Seoul National University, Seoul, South Korea.
FAU - Lee, Haekyung
AU  - Lee H
AD  - Division of Nephrology, Department of Internal Medicine, Soonchunhyang University 
      Seoul Hospital, Seoul, South Korea.
FAU - Kim, Sehee
AU  - Kim S
AD  - Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, 
      Seoul, South Korea.
FAU - Kim, Ye-Jee
AU  - Kim YJ
AD  - Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, 
      Seoul, South Korea.
FAU - Lee, Hyunsuk
AU  - Lee H
AD  - Department of Internal Medicine, Seoul National University Hospital, Seoul, South 
      Korea.
AD  - Department of Translational Medicine, Seoul National University College of 
      Medicine, Seoul, Korea.
AD  - Genomic Medicine Institute, Medical Research Center, Seoul National University 
      College of Medicine, Seoul, South Korea.
FAU - Lee, Junhyeong
AU  - Lee J
AD  - Graduate School of Data Science, Seoul National University, Seoul, South Korea.
FAU - Kwak, Soo Heon
AU  - Kwak SH
AD  - Department of Internal Medicine, Seoul National University Hospital, Seoul, South 
      Korea.
FAU - Lee, Seunggeun
AU  - Lee S
AD  - Graduate School of Data Science, Seoul National University, Seoul, South Korea. 
      lee7801@snu.ac.kr.
LA  - eng
GR  - 2020H1D3A2A03100666/Brain Pool Plus (Brain Pool+) Program/
PT  - Journal Article
DEP - 20240308
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - *Prediabetic State/epidemiology/genetics
MH  - Prospective Studies
MH  - Genetic Risk Score
MH  - Clinical Relevance
MH  - Longitudinal Studies
MH  - Blood Glucose/analysis
MH  - Risk Factors
MH  - Republic of Korea/epidemiology
PMC - PMC10923897
COIS- The authors declare no competing interests.
EDAT- 2024/03/09 10:42
MHDA- 2024/03/11 06:43
PMCR- 2024/03/08
CRDT- 2024/03/08 23:21
PHST- 2023/05/30 00:00 [received]
PHST- 2024/02/22 00:00 [accepted]
PHST- 2024/03/11 06:43 [medline]
PHST- 2024/03/09 10:42 [pubmed]
PHST- 2024/03/08 23:21 [entrez]
PHST- 2024/03/08 00:00 [pmc-release]
AID - 10.1038/s41598-024-55313-0 [pii]
AID - 55313 [pii]
AID - 10.1038/s41598-024-55313-0 [doi]
PST - epublish
SO  - Sci Rep. 2024 Mar 8;14(1):5749. doi: 10.1038/s41598-024-55313-0.