PMID- 38459526 OWN - NLM STAT- MEDLINE DCOM- 20240311 LR - 20240312 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Mar 8 TI - Impact of age, sex, and thyroid autoimmunity on the association between selenium intake and type 2 diabetes mellitus. PG - 743 LID - 10.1186/s12889-024-18225-2 [doi] LID - 743 AB - BACKGROUND: The association between dietary selenium(Se) intake and type 2 diabetes mellitus (T2DM) remains controversial. The present study aimed to investigate this association using data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2007-2012. METHODS: Three thousand seventy three individuals aged 20 years and above were eligible for inclusion in this cross-sectional study. The average age of the participants was 50.74 years and the proportions of males and females were nearly equal (49.12% vs. 50.88%). The odds ratios (OR) of the association between dietary Se intake (log2-transformed) and T2DM were examined through the multivariate logistic regression model. Subgroup analyses were conducted based on age, sex, and thyroid autoimmunity to assess the potential impact of these variables on the relationship. Fitted smoothing curves and threshold effect analysis were conducted to describe the nonlinear relationship. RESULTS: In the fully adjusted model, a significant positive association between Se intake and T2DM was observed (OR = 1.49, 95% CI: 1.16, 1.90, p = 0.0017). After stratifying the data by age, sex, and thyroid autoimmunity, a significant positive association between Se intake and T2DM was observed in individuals under 65 years of age, males, and those with negative thyroid autoimmunity. A two-segment linear regression model was analyzed for sex stratification, revealing a threshold effect in males with an inflection point of 90.51 mug, and an inverted U-shaped relationship in females with an inflection point of 109.90 mug, respectively. CONCLUSIONS: The present study found a positive relationship between Se intake and the prevalence of T2DM. This association is particularly significant in younger individuals, males, and those with negative thyroid autoimmunity. Our results should be validated in future large prospective studies in different populations. CI - (c) 2024. The Author(s). FAU - Ma, Xiao-Man AU - Ma XM AD - Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. AD - Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China. FAU - Li, Ke-Xuan AU - Li KX AD - Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. AD - Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China. FAU - Chen, Zi-Qiu AU - Chen ZQ AD - Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. AD - Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China. FAU - Wu, Cai-Mei AU - Wu CM AD - Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. AD - Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China. FAU - Liao, Wan-Zhe AU - Liao WZ AD - Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. AD - Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China. FAU - Guo, Xu-Guang AU - Guo XG AD - Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. gysygxg@gmail.com. AD - Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China. gysygxg@gmail.com. AD - Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, King Med School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 510000, China. gysygxg@gmail.com. LA - eng PT - Journal Article DEP - 20240308 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - H6241UJ22B (Selenium) SB - IM MH - Male MH - Female MH - Humans MH - Middle Aged MH - Child, Preschool MH - *Diabetes Mellitus, Type 2/epidemiology MH - Thyroid Gland MH - Nutrition Surveys MH - *Selenium MH - Autoimmunity MH - Prospective Studies MH - Cross-Sectional Studies PMC - PMC10921729 OTO - NOTNLM OT - NHANES OT - Selenium intake OT - T2DM OT - Threshold effect OT - Thyroid autoimmunity COIS- The authors declare no competing interests. EDAT- 2024/03/09 10:44 MHDA- 2024/03/11 06:44 PMCR- 2024/03/08 CRDT- 2024/03/08 23:51 PHST- 2023/11/02 00:00 [received] PHST- 2024/02/28 00:00 [accepted] PHST- 2024/03/11 06:44 [medline] PHST- 2024/03/09 10:44 [pubmed] PHST- 2024/03/08 23:51 [entrez] PHST- 2024/03/08 00:00 [pmc-release] AID - 10.1186/s12889-024-18225-2 [pii] AID - 18225 [pii] AID - 10.1186/s12889-024-18225-2 [doi] PST - epublish SO - BMC Public Health. 2024 Mar 8;24(1):743. doi: 10.1186/s12889-024-18225-2.