PMID- 38461145
OWN - NLM
STAT- MEDLINE
DCOM- 20240419
LR  - 20240426
IS  - 1424-3911 (Electronic)
IS  - 1424-3903 (Print)
IS  - 1424-3903 (Linking)
VI  - 24
IP  - 3
DP  - 2024 May
TI  - Circulating immune signatures in chronic pancreatitis with and without preceding 
      acute pancreatitis: A pilot study.
PG  - 384-393
LID - S1424-3903(24)00056-5 [pii]
LID - 10.1016/j.pan.2024.02.012 [doi]
AB  - OBJECTIVE: To investigate profiles of circulating immune signatures in healthy 
      controls and chronic pancreatitis patients (CP) with and without a preceding 
      history of acute pancreatitis (AP). METHODS: We performed a phase 1, 
      cross-sectional analysis of prospectively collected serum samples from the 
      PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translation 
      StuDies (PROCEED) study. All samples were collected during a clinically quiescent 
      phase. CP subjects were categorized into two subgroups based on preceding 
      episode(s) of AP. Healthy controls were included for comparison. Blinded samples 
      were analyzed using an 80-plex Luminex assay of cytokines, chemokines, and 
      adhesion molecules. Group and pairwise comparisons of analytes were performed 
      between the subgroups. RESULTS: In total, 133 patients with CP (111 with AP and 
      22 without AP) and 50 healthy controls were included. Among the 80 analytes 
      studied, CP patients with a history of AP had significantly higher serum levels 
      of pro-inflammatory cytokines (interleukin (IL)-6, IL-8, IL-1 receptor 
      antagonist, IL-15) and chemokines (Cutaneous T-Cell Attracting Chemokine (CTACK), 
      Monokine induced Gamma Interferon (MIG), Macrophage-derived Chemokine (MDC), 
      Monocyte Chemoattractant Protein-1 (MCP-1)) compared to CP without preceding AP 
      and controls. In contrast, CP patients without AP had immune profiles 
      characterized by low systemic inflammation and downregulation of 
      anti-inflammatory mediators, including IL-10. CONCLUSION: CP patients with a 
      preceding history of AP have signs of systemic inflammatory activity even during 
      a clinically quiescent phase. In contrast, CP patients without a history of AP 
      have low systemic inflammatory activity. These findings suggest the presence of 
      two immunologically diverse subtypes of CP.
CI  - Copyright (c) 2024 IAP and EPC. Published by Elsevier B.V. All rights reserved.
FAU - Hagn-Meincke, Rasmus
AU  - Hagn-Meincke R
AD  - Centre for Pancreatic Diseases and Mech-Sense, Department of Gastroenterology & 
      Hepatology, Aalborg University Hospital, Aalborg, Denmark; Division of 
      Gastroenterology and Hepatology, Department of Medicine, Stanford University 
      School of Medicine, Stanford, CA, USA.
FAU - Yadav, Dhiraj
AU  - Yadav D
AD  - Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, 
      Pittsburgh, PA, USA.
FAU - Andersen, Dana K
AU  - Andersen DK
AD  - Division of Digestive Diseases and Nutrition, National Institute of Diabetes and 
      Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
FAU - Vege, Santhi Swaroop
AU  - Vege SS
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
FAU - Fogel, Evan L
AU  - Fogel EL
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Indiana 
      University School of Medicine, Indianapolis, IN, USA.
FAU - Serrano, Jose
AU  - Serrano J
AD  - Division of Digestive Diseases and Nutrition, National Institute of Diabetes and 
      Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
FAU - Bellin, Melena D
AU  - Bellin MD
AD  - Division of Pediatric Endocrinology, University of Minnesota, Minnesota, MN, USA.
FAU - Topazian, Mark D
AU  - Topazian MD
AD  - Division of Digestive Diseases and Nutrition, National Institute of Diabetes and 
      Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
FAU - Conwell, Darwin L
AU  - Conwell DL
AD  - Department of Medicine, University of Kentucky, Lexington, KY, USA.
FAU - Li, Liang
AU  - Li L
AD  - Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA.
FAU - Van Den Eeden, Stephen K
AU  - Van Den Eeden SK
AD  - Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
FAU - Drewes, Asbjorn M
AU  - Drewes AM
AD  - Centre for Pancreatic Diseases and Mech-Sense, Department of Gastroenterology & 
      Hepatology, Aalborg University Hospital, Aalborg, Denmark.
FAU - Pandol, Stephen J
AU  - Pandol SJ
AD  - Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los 
      Angeles, CA, USA.
FAU - Forsmark, Chris E
AU  - Forsmark CE
AD  - Division of Gastroenterology, Hepatology, and Nutrition. University of Florida, 
      Gainesville, FL, USA.
FAU - Fisher, William E
AU  - Fisher WE
AD  - Division of General Surgery, Baylor College of Medicine, Houston, TX, USA.
FAU - Hart, Phil A
AU  - Hart PA
AD  - Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State 
      University Wexner Medical Center, Columbus, OH, USA.
FAU - Olesen, Soren S
AU  - Olesen SS
AD  - Centre for Pancreatic Diseases and Mech-Sense, Department of Gastroenterology & 
      Hepatology, Aalborg University Hospital, Aalborg, Denmark.
FAU - Park, Walter G
AU  - Park WG
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Stanford 
      University School of Medicine, Stanford, CA, USA. Electronic address: 
      wgpark@stanford.edu.
CN  - Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer 
      (CPDPC)
LA  - eng
GR  - U01 DK108288/DK/NIDDK NIH HHS/United States
GR  - U01 DK108323/DK/NIDDK NIH HHS/United States
GR  - U01 DK108332/DK/NIDDK NIH HHS/United States
GR  - U01 DK108326/DK/NIDDK NIH HHS/United States
GR  - U01 DK126300/DK/NIDDK NIH HHS/United States
GR  - U01 DK108320/DK/NIDDK NIH HHS/United States
GR  - U01 DK108328/DK/NIDDK NIH HHS/United States
GR  - U01 DK108300/DK/NIDDK NIH HHS/United States
GR  - U01 DK108306/DK/NIDDK NIH HHS/United States
GR  - U01 DK108314/DK/NIDDK NIH HHS/United States
GR  - U01 DK108327/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20240228
PL  - Switzerland
TA  - Pancreatology
JT  - Pancreatology : official journal of the International Association of 
      Pancreatology (IAP) ... [et al.]
JID - 100966936
RN  - 0 (Cytokines)
RN  - 0 (Chemokines)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Humans
MH  - Pilot Projects
MH  - Acute Disease
MH  - Cross-Sectional Studies
MH  - *Cytokines
MH  - *Pancreatitis, Chronic
MH  - Chemokines
MH  - Interleukin-6
PMC - PMC11023786
MID - NIHMS1974159
OTO - NOTNLM
OT  - Chronic pancreatitis
OT  - Immune signatures
EDAT- 2024/03/10 00:42
MHDA- 2024/04/19 06:43
PMCR- 2025/05/01
CRDT- 2024/03/09 21:57
PHST- 2023/11/20 00:00 [received]
PHST- 2024/02/05 00:00 [revised]
PHST- 2024/02/21 00:00 [accepted]
PHST- 2025/05/01 00:00 [pmc-release]
PHST- 2024/04/19 06:43 [medline]
PHST- 2024/03/10 00:42 [pubmed]
PHST- 2024/03/09 21:57 [entrez]
AID - S1424-3903(24)00056-5 [pii]
AID - 10.1016/j.pan.2024.02.012 [doi]
PST - ppublish
SO  - Pancreatology. 2024 May;24(3):384-393. doi: 10.1016/j.pan.2024.02.012. Epub 2024 
      Feb 28.