PMID- 38461575
OWN - NLM
STAT- MEDLINE
DCOM- 20240329
LR  - 20240329
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 274
DP  - 2024 Apr 1
TI  - Maternal exposure to deltamethrin during pregnancy and lactation impairs 
      neurodevelopment of male offspring.
PG  - 116196
LID - S0147-6513(24)00272-0 [pii]
LID - 10.1016/j.ecoenv.2024.116196 [doi]
AB  - Deltamethrin (DM) is a highly effective and widely used pyrethroid pesticide. It 
      is an environmental factor affecting public and occupational health and exerts 
      direct toxic effects on the central nervous system. As the major target organs 
      for neurotoxicity of DM, the hippocampus and the cerebellum are critical to the 
      learning and motor function. Pregnant Wistar rats were randomly divided into four 
      groups and gavaged at doses of 0, 1, 4or 10 mg/kg/d DM from gestational day (GD) 
      0 to postnatal day (PN) 21. The PC12 cells were selected to further verify the 
      regulatory mechanisms of DM on the neurodevelopmental injury. We found that 
      maternal exposure to DM caused learning, memory and motor dysfunction in male 
      offspring. Maternal exposure to DM induced the decrease in the density of 
      hippocampal dendritic spines in male offspring through the reduced expression of 
      M1 mAchRs, which in turn reduced the mediated AKT/mTOR signaling pathway, 
      contributing to the inhibition of dynamic changes of GluA1. Meanwhile, DM 
      exposure inhibited the BDNF/TrkB signaling pathway, thereby reducing 
      phosphorylation of stathmin and impairing cerebellar purkinje cell dendrite 
      growth and development. Taken together, maternal exposure to DM during pregnancy 
      and lactation could impair neurodevelopment of male offspring.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Hao, Fei
AU  - Hao F
AD  - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention 
      (China Medical University), Ministry of Education, China; Department of 
      Occupational and Environmental Health, School of Public Health, China Medical 
      University, Shenyang, China; The Center for Disease Control and Prevention, 
      Dalian Jinzhou New District, Dalian, China.
FAU - Bu, Ye
AU  - Bu Y
AD  - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention 
      (China Medical University), Ministry of Education, China; Department of 
      Occupational and Environmental Health, School of Public Health, China Medical 
      University, Shenyang, China; Department of Planned Immunization, Liaoning 
      Provincial Center for Disease Control and Prevention, Shenyang, China.
FAU - Huang, Shasha
AU  - Huang S
AD  - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention 
      (China Medical University), Ministry of Education, China; Department of 
      Occupational and Environmental Health, School of Public Health, China Medical 
      University, Shenyang, China.
FAU - Li, Wanqi
AU  - Li W
AD  - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention 
      (China Medical University), Ministry of Education, China; Department of 
      Occupational and Environmental Health, School of Public Health, China Medical 
      University, Shenyang, China.
FAU - Feng, Huiwen
AU  - Feng H
AD  - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention 
      (China Medical University), Ministry of Education, China; Department of 
      Occupational and Environmental Health, School of Public Health, China Medical 
      University, Shenyang, China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention 
      (China Medical University), Ministry of Education, China; Department of 
      Occupational and Environmental Health, School of Public Health, China Medical 
      University, Shenyang, China. Electronic address: yuanwang@cmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240310
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 2JTS8R821G (decamethrin)
RN  - 0 (Nitriles)
RN  - 0 (Pyrethrins)
SB  - IM
MH  - Pregnancy
MH  - Rats
MH  - Animals
MH  - Humans
MH  - Female
MH  - Male
MH  - *Maternal Exposure/adverse effects
MH  - Rats, Wistar
MH  - *Prenatal Exposure Delayed Effects/metabolism
MH  - Lactation
MH  - Hippocampus/metabolism
MH  - *Nitriles
MH  - *Pyrethrins
OTO - NOTNLM
OT  - cerebellum
OT  - deltamethrin
OT  - hippocampus
OT  - neurodevelopment
OT  - neurotoxicity
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/03/11 00:42
MHDA- 2024/03/29 06:46
CRDT- 2024/03/10 19:01
PHST- 2023/12/19 00:00 [received]
PHST- 2024/02/28 00:00 [revised]
PHST- 2024/03/07 00:00 [accepted]
PHST- 2024/03/29 06:46 [medline]
PHST- 2024/03/11 00:42 [pubmed]
PHST- 2024/03/10 19:01 [entrez]
AID - S0147-6513(24)00272-0 [pii]
AID - 10.1016/j.ecoenv.2024.116196 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2024 Apr 1;274:116196. doi: 10.1016/j.ecoenv.2024.116196. 
      Epub 2024 Mar 10.