PMID- 38461723
OWN - NLM
STAT- MEDLINE
DCOM- 20240410
LR  - 20240410
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 447
DP  - 2024 Jul 30
TI  - (-)-Epicatechin ameliorates type 2 diabetes mellitus by reshaping the gut 
      microbiota and Gut-Liver axis in GK rats.
PG  - 138916
LID - S0308-8146(24)00565-X [pii]
LID - 10.1016/j.foodchem.2024.138916 [doi]
AB  - As one of the most abundant plant polyphenols in the human diet, (-)-epicatechin 
      (EC) can improve insulin sensitivity and regulate glucose homeostasis. However, 
      the primary mechanisms involved in EC anti-T2DM benefits remain unclear. The 
      present study explored the effects of EC on the gut microbiota and liver 
      transcriptome in type 2 diabetes mellitus (T2DM) Goto-Kakizaki rats for the first 
      time. The findings showed that EC protected glucose homeostasis, alleviated 
      systemic oxidative stress, relieved liver damage, and increased serum insulin. 
      Further investigation showed that EC reshaped gut microbiota structure, including 
      inhibiting the proliferation of lipopolysaccharide (LPS)-producing bacteria and 
      reducing serum LPS. In addition, transcriptome analysis revealed that the insulin 
      signaling pathway may be the core pathway of the EC anti-T2DM effect. Therefore, 
      EC may modulate the gut microbiota and liver insulin signaling pathways by the 
      gut-liver axis to alleviate T2DM. As a diet supplement, EC has promising 
      potential in T2DM prevention and treatment.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Zeng, Hongzhe
AU  - Zeng H
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Liu, Changwei
AU  - Liu C
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Wan, Liwei
AU  - Wan L
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Peng, Liyuan
AU  - Peng L
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Wen, Shuai
AU  - Wen S
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Fang, Wenwen
AU  - Fang W
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Chen, Hongyu
AU  - Chen H
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Wang, Kuofei
AU  - Wang K
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Yang, Xiaomei
AU  - Yang X
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China.
FAU - Huang, Jian'an
AU  - Huang J
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China. 
      Electronic address: Jian7513@hunau.edu.cn.
FAU - Liu, Zhonghua
AU  - Liu Z
AD  - Key Laboratory of Tea Science of Ministry of Education, National Research Center 
      of Engineering and Technology for Utilization of Botanical Functional 
      Ingredients, Co-Innovation Center of Education Ministry for Utilization of 
      Botanical Functional Ingredients, Key Laboratory for Evaluation and Utilization 
      of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural 
      Affairs of China, Hunan Agricultural University, Changsha 410128, China. 
      Electronic address: zhonghua-liu-ms@hunau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240306
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 8R1V1STN48 (Catechin)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Rats
MH  - Humans
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/drug therapy/genetics
MH  - *Catechin/metabolism
MH  - *Gastrointestinal Microbiome
MH  - Lipopolysaccharides/pharmacology
MH  - Blood Glucose/metabolism
MH  - Insulin
MH  - Liver/metabolism
OTO - NOTNLM
OT  - (-)-Epicatechin
OT  - Antidiabetic effects
OT  - GK rats
OT  - Gut microbiota
OT  - Gut-Liver axis
OT  - Insulin signaling pathway
OT  - Lipopolysaccharide
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/03/11 00:42
MHDA- 2024/04/10 06:43
CRDT- 2024/03/10 19:08
PHST- 2023/11/02 00:00 [received]
PHST- 2024/02/14 00:00 [revised]
PHST- 2024/02/29 00:00 [accepted]
PHST- 2024/04/10 06:43 [medline]
PHST- 2024/03/11 00:42 [pubmed]
PHST- 2024/03/10 19:08 [entrez]
AID - S0308-8146(24)00565-X [pii]
AID - 10.1016/j.foodchem.2024.138916 [doi]
PST - ppublish
SO  - Food Chem. 2024 Jul 30;447:138916. doi: 10.1016/j.foodchem.2024.138916. Epub 2024 
      Mar 6.