PMID- 38461902
OWN - NLM
STAT- MEDLINE
DCOM- 20240415
LR  - 20240415
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 354
DP  - 2024 Jun 1
TI  - Altered neural representation of olfactory food reward in the nucleus accumbens 
      after acute stress.
PG  - 239-246
LID - S0165-0327(24)00430-0 [pii]
LID - 10.1016/j.jad.2024.03.015 [doi]
AB  - Acute stress impairs reward processing. The nucleus accumbens (NAcc) plays an 
      important role in the processing of primary rewards such as food. The present 
      study investigates how acute stress affects the olfactory food reward processing 
      in the NAcc using the representational similarity analysis. Forty-eight 
      participants underwent an olfactory fMRI session following either an acute 
      psychosocial stress (N = 24; stress group) or a control (N = 24; control group). 
      Brain activation was recorded during the anticipatory and the perceptual phases 
      of high-calorie food, low-calorie food, and non-food odor stimuli. Compared to 
      the control group, the stress group rated the high-calorie food odor as 
      significantly more pleasant (p = 0.005). In the NAcc, acute stress significantly 
      reduced the dissimilarity of food and non-food odors in the perceptual phase (p = 
      0.027) and marginally reduced the dissimilarity of high- and low-calorie foods in 
      the anticipatory phase (p = 0.095). Significant negative correlations were 
      observed between the level of NAcc representational differentiation for high- and 
      low-calorie food odors during perception and the difference in pleasantness 
      ratings between high- and low-calorie food odors (r = -0.40, p = 0.005). These 
      findings suggest that acute stress may impair participants' ability to 
      discriminate between olfactory food rewards, leading individuals to seek out more 
      palatable foods in stressful situations in order to maintain positive emotions.
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Nie, Haoyu
AU  - Nie H
AD  - MOE Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest 
      University, Chongqing, China.
FAU - Hu, Xin
AU  - Hu X
AD  - MOE Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest 
      University, Chongqing, China.
FAU - Gao, Yuan
AU  - Gao Y
AD  - MOE Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest 
      University, Chongqing, China.
FAU - Ma, Yihang
AU  - Ma Y
AD  - MOE Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest 
      University, Chongqing, China.
FAU - Han, Pengfei
AU  - Han P
AD  - MOE Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest 
      University, Chongqing, China. Electronic address: p.han@foxmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240308
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Humans
MH  - *Nucleus Accumbens/diagnostic imaging
MH  - *Food
MH  - Brain/physiology
MH  - Smell
MH  - Reward
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - Acute stress
OT  - Food odor
OT  - Nucleus accumbens
OT  - Representational similarity analysis
OT  - fMRI
COIS- Declaration of competing interest This manuscript has not been published or 
      presented elsewhere in part or in entirety and is not under consideration by 
      another journal. All the authors approved the manuscript, agreed with its 
      submission to your esteemed journal, and contributed significantly to its 
      creation. All study participants provided informed consent, and the study design 
      was approved by the appropriate ethics review board. We have read and understood 
      your journal's policies and believe that neither the manuscript nor the study 
      violates any of these. There are no conflicts of interest to declare.
EDAT- 2024/03/11 00:42
MHDA- 2024/04/15 06:42
CRDT- 2024/03/10 20:13
PHST- 2023/07/11 00:00 [received]
PHST- 2024/02/08 00:00 [revised]
PHST- 2024/03/07 00:00 [accepted]
PHST- 2024/04/15 06:42 [medline]
PHST- 2024/03/11 00:42 [pubmed]
PHST- 2024/03/10 20:13 [entrez]
AID - S0165-0327(24)00430-0 [pii]
AID - 10.1016/j.jad.2024.03.015 [doi]
PST - ppublish
SO  - J Affect Disord. 2024 Jun 1;354:239-246. doi: 10.1016/j.jad.2024.03.015. Epub 
      2024 Mar 8.