PMID- 38462366
OWN - NLM
STAT- MEDLINE
DCOM- 20240312
LR  - 20240312
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 104
IP  - 11
DP  - 2024 Mar 19
TI  - [Pathogenetic analysis of transfusion-related acute lung injury caused by human 
      leukocytes antigen antibody against human leukocyte antigen].
PG  - 883-887
LID - 10.3760/cma.j.cn112137-20231201-01263 [doi]
AB  - From September 2019 to October 2020, pathogenetic analysis of three patients 
      clinically diagnosed as transfusion-related acute lung injury (TRALI) caused by 
      human leukocyte antibodies was conducted by Guangzhou Blood Centre, including 2 
      males and 1 female, aged 56, 50 and 20 years old, respectively. Solid phase 
      agglutination, anti-human globulin test and flow cytometry method were used to 
      detect the presence of antibodies against patients. Sequencing-based human 
      leukocyte antigen (HLA-SBT) typing technique was used to detect the human 
      leukocyte antigen (HLA) genotypes of patients. Lifecodes single antigen class Ⅰ/Ⅱ 
      kit (LSA-Ⅰ/Ⅱ) were used to detect the specificity of HLA-class Ⅰ and class Ⅱ 
      antibodies in donor blood by Luminex 200 liquid suspension chip system. The HLA 
      specific antibodies and corresponding epitopes in donors were also analyzed. The 
      results showed that　HLA class Ⅰ or class Ⅱ specific antibodies against TRALI 
      patients were detected in the blood donors. The plasma of donor 3 received by 
      patient 1 contained antibodies against the patient's HLA-DRB1*09ratio01 antigen, and 
      the epitopes mediating the antibody reaction of the donor and recipient were 70R, 
      31I, 70QA. There were antibodies against the HLA-A*11ratio02, HLA-A*11ratio01, 
      DRB1*12ratio02, and DRB1*09ratio01 antigens of patient 2 in the plasma of donor 4, and 
      the associated antigenic epitopes were 151AHA, 57V, and 16Y. Antibodies against 
      the HLA-DRB1*14ratio04, DRB1*11ratio01, and DPB1*05ratio01 antigens of patient 3 were present 
      in the plasma of donor 6 and donor 7, and the associated epitopes were 96HK, 
      140TV, 13SE, and 111K.　Three cases of TRALI were confirmed to be caused by HLA 
      antibodies through laboratory analysis, and human leukocyte antibody detection 
      should be paid attention in clinically suspected cases of TRALI, and targeted 
      diagnosis and treatment should be given.
FAU - Deng, J
AU  - Deng J
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
FAU - Xu, X Z
AU  - Xu XZ
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
FAU - Ye, X
AU  - Ye X
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
FAU - Chen, Y K
AU  - Chen YK
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
FAU - Ding, H Q
AU  - Ding HQ
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
FAU - Liu, J
AU  - Liu J
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
FAU - Xia, W J
AU  - Xia WJ
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
FAU - Chen, D W
AU  - Chen DW
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
FAU - Xu, Y R
AU  - Xu YR
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou Blood Center, Guangzhou 
      510095, China.
LA  - chi
GR  - 202201011749，2023A03J0549，2023A03J0552，2024A03J0374/Science and Technology 
      Projects in Guangzhou/
GR  - 2021-2023/Key Medical Disciplines and Specialties Program of Guangzhou/
GR  - 2022A1515012096/Natural Science Foundation of Guangdong Province of China/
GR  - 81970169/National Natural Science Foundation of China/
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Isoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (HLA-A Antigens)
RN  - 0 (Epitopes)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Transfusion-Related Acute Lung Injury
MH  - HLA-DRB1 Chains
MH  - Isoantibodies
MH  - HLA Antigens
MH  - Histocompatibility Antigens Class I
MH  - Blood Donors
MH  - HLA-A Antigens
MH  - Epitopes
EDAT- 2024/03/11 00:42
MHDA- 2024/03/12 06:42
CRDT- 2024/03/10 22:18
PHST- 2024/03/12 06:42 [medline]
PHST- 2024/03/11 00:42 [pubmed]
PHST- 2024/03/10 22:18 [entrez]
AID - 10.3760/cma.j.cn112137-20231201-01263 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2024 Mar 19;104(11):883-887. doi: 
      10.3760/cma.j.cn112137-20231201-01263.