PMID- 38462604
OWN - NLM
STAT- MEDLINE
DCOM- 20240312
LR  - 20240313
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Mar 11
TI  - The interaction between general or abdominal obesity and hypertension on the risk 
      of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from 
      the RaNCD cohort study.
PG  - 752
LID - 10.1186/s12889-024-18290-7 [doi]
LID - 752
AB  - BACKGROUND: Interactions between risk factors may influence disease severity. 
      Knowing this relationship is important for preventive interventions and disease 
      control. The purpose of this study was to determine the interactions effects of 
      obesity and hypertension on the risk of type 2 diabetes mellitus (T2DM). METHODS: 
      The data of 9,283 adults 35 to 65 years were examined from the cohort study of 
      Ravansar Non-Communicable Disease (RaNCD). Waist circumference (WC) was used to 
      identify both general and abdominal obesity based on body mass index (BMI). To 
      assess the interaction between hypertension and obesity (general/abdominal) and 
      the risk of T2DM, the additive interaction was calculated. RESULTS: The adjusted 
      odds ratios for T2DM were 2.38 (1.67, 3.41) in men and 4.02 (2.47, 6.47) in women 
      for the combinations of hypertension and abdominal obesity. The adjusted odds 
      ratios for T2DM were 2.53 (1.63, 3.82) in men and 2.66 (1.92, 3.70) in women for 
      the combinations of hypertension and general obesity. The results of the additive 
      interaction indicators were inconsistent with gender. The relative excess risk 
      due to interaction (interaction between hypertension and central obesity) (RERI), 
      attributable proportion due to interaction (AP) and synergy index (SI) were0.27 
      (-1.01, 1.54), 0.11 (-0.41, 0.63) and 1.23 (0.41, 3.68) in male and were 0.61 
      (-1.12, 2.33), 0.23 (0.08, 0.37) and 1.26 (0.60, 2.61) in female, respectively. 
      CONCLUSION: General/abdominal obesity and hypertension have a synergistic effect 
      on the risk of T2DM. The recommendation for preventing T2DM is lifestyle 
      modification. Large longitudinal studies are necessary to investigate causal 
      relationships.
CI  - (c) 2024. The Author(s).
FAU - Pasdar, Yahya
AU  - Pasdar Y
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Rezaeian, Shahab
AU  - Rezaeian S
AD  - Infectious Disease Research Center, Health Institute, Kermanshah University of 
      Medical Sciences, Kermanshah, Iran.
FAU - Mohammadi, Ehsan
AU  - Mohammadi E
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Khosravi Shadmani, Fatemeh
AU  - Khosravi Shadmani F
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Shahnazi, Narges
AU  - Shahnazi N
AD  - Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Najafi, Farid
AU  - Najafi F
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
AD  - Cardiovascular Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Nazar, Mehdi Moradi
AU  - Nazar MM
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Darbandi, Mitra
AU  - Darbandi M
AUID- ORCID: 0000-0002-9173-8814
AD  - Research Center for Environmental Determinants of Health (RCEDH), Health 
      Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. 
      m.darbandi@kums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20240311
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Female
MH  - Male
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Obesity, Abdominal/epidemiology/complications
MH  - Cross-Sectional Studies
MH  - Iran/epidemiology
MH  - Cohort Studies
MH  - *Noncommunicable Diseases
MH  - Obesity/epidemiology/complications
MH  - Risk Factors
MH  - *Hypertension/epidemiology/complications
MH  - Waist Circumference
MH  - Body Mass Index
PMC - PMC10926646
OTO - NOTNLM
OT  - Abdominal obesity
OT  - Diabetes mellitus
OT  - General obesity
OT  - Hypertension
COIS- The authors declare no competing interests.
EDAT- 2024/03/11 06:42
MHDA- 2024/03/12 11:44
PMCR- 2024/03/11
CRDT- 2024/03/11 00:13
PHST- 2023/11/24 00:00 [received]
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/12 11:44 [medline]
PHST- 2024/03/11 06:42 [pubmed]
PHST- 2024/03/11 00:13 [entrez]
PHST- 2024/03/11 00:00 [pmc-release]
AID - 10.1186/s12889-024-18290-7 [pii]
AID - 18290 [pii]
AID - 10.1186/s12889-024-18290-7 [doi]
PST - epublish
SO  - BMC Public Health. 2024 Mar 11;24(1):752. doi: 10.1186/s12889-024-18290-7.