PMID- 38463584
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240312
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 16
IP  - 2
DP  - 2024
TI  - Thyroid autoimmunity in relation to HLA-DRB1 and HLA-DQB1 polymorphism in 
      nonsegmental vitiligo: a cross-sectional-study.
PG  - 524-530
AB  - OBJECTIVES: Nonsegmental vitiligo (NSV) is frequently associated with thyroid 
      autoimmunity (TAI), however, the immunopathogenic mechanisms of such association 
      remain to be investigated. The aims of this work were to estimate the frequency 
      of TAI and to describe the genetic polymorphism in the human leukocyte antigen 
      (HLA)-DRB1 and -DQB1 loci in TAI susceptibility among patients with NSV. PATIENTS 
      AND METHODS: In this cross-sectional study, screening for TAI was performed in 97 
      Moroccan patients with NSV by measuring antibodies against thyroid peroxidase 
      (TPOAb) and thyroglobulin (TGAb). HLA-DRB1 and -DQB1 were determined with single 
      specific primer-polymerase chain reaction (PCR-SSP) typing methods. RESULTS: TAI 
      was diagnosed in 20 patients with NSV (20.6%). The phenotypic frequency of 
      DQB1*05 (OR = 5.04; P = 0.006; pc = 0.036) was significantly higher in NSV 
      patients with TAI. Genotype DQB1*05/DQB1*06 (OR = 25.33; P = 0.001; pc = 0.003) 
      confer susceptibility to TAI in NSV patients. NSV patients with TAI and early 
      onset vitiligo have an extremely high phenotype frequency of DQB1*05 allele (OR = 
      14.67; P = 0.001; pc = 0.048) and DQB1*05/DQB1*06 genotype (OR = 26.55; P = 0.01; 
      pc = 0.03). TAI in patients with NSV was (6.2%) associated with onset of clinical 
      thyroid disease based on TSH and free T4. CONCLUSION: Our findings suggest that 
      HLA-DQ polymorphisms influence TAI risk in subjects with NSV, although HLA does 
      not completely explain the co-occurrence of these two diseases.
CI  - AJTR Copyright (c) 2024.
FAU - Bouayad, Abdellatif
AU  - Bouayad A
AD  - Faculty of Medicine and Pharmacy, Mohammed First University Oujda, Morocco.
FAU - Benzekri, Laila
AU  - Benzekri L
AD  - Department of Dermatology, Faculty of Medicine and Pharmacy, Mohammed V Souissi 
      University, Ibn Sina Hospital Rabat, Morocco.
LA  - eng
PT  - Journal Article
DEP - 20240215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC10918139
OTO - NOTNLM
OT  - HLA
OT  - Moroccan population
OT  - Nonsegmental vitiligo
OT  - thyroid autoimmunity
COIS- None.
EDAT- 2024/03/11 06:42
MHDA- 2024/03/11 06:43
PMCR- 2024/02/15
CRDT- 2024/03/11 04:23
PHST- 2023/12/07 00:00 [received]
PHST- 2024/01/28 00:00 [accepted]
PHST- 2024/03/11 06:43 [medline]
PHST- 2024/03/11 06:42 [pubmed]
PHST- 2024/03/11 04:23 [entrez]
PHST- 2024/02/15 00:00 [pmc-release]
AID - 10.62347/LDYE8203 [doi]
PST - epublish
SO  - Am J Transl Res. 2024 Feb 15;16(2):524-530. doi: 10.62347/LDYE8203. eCollection 
      2024.