PMID- 38464367
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240312
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 15
IP  - 2
DP  - 2024 Feb 15
TI  - Genotype-based precision nutrition strategies for the prediction and clinical 
      management of type 2 diabetes mellitus.
PG  - 142-153
LID - 10.4239/wjd.v15.i2.142 [doi]
AB  - Globally, type 2 diabetes mellitus (T2DM) is one of the most common metabolic 
      disorders. T2DM physiopathology is influenced by complex interrelationships 
      between genetic, metabolic and lifestyle factors (including diet), which differ 
      between populations and geographic regions. In fact, excessive consumptions of 
      high fat/high sugar foods generally increase the risk of developing T2DM, whereas 
      habitual intakes of plant-based healthy diets usually exert a protective effect. 
      Moreover, genomic studies have allowed the characterization of sequence DNA 
      variants across the human genome, some of which may affect gene expression and 
      protein functions relevant for glucose homeostasis. This comprehensive literature 
      review covers the impact of gene-diet interactions on T2DM susceptibility and 
      disease progression, some of which have demonstrated a value as biomarkers of 
      personal responses to certain nutritional interventions. Also, novel 
      genotype-based dietary strategies have been developed for improving T2DM control 
      in comparison to general lifestyle recommendations. Furthermore, progresses in 
      other omics areas (epigenomics, metagenomics, proteomics, and metabolomics) are 
      improving current understanding of genetic insights in T2DM clinical outcomes. 
      Although more investigation is still needed, the analysis of the genetic make-up 
      may help to decipher new paradigms in the pathophysiology of T2DM as well as 
      offer further opportunities to personalize the screening, prevention, diagnosis, 
      management, and prognosis of T2DM through precision nutrition.
CI  - (c)The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Ramos-Lopez, Omar
AU  - Ramos-Lopez O
AD  - Medicine and Psychology School, Autonomous University of Baja California, Tijuana 
      22390, Baja California, Mexico. oscar.omar.ramos.lopez@uabc.edu.mx.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10921165
OTO - NOTNLM
OT  - Diet
OT  - Genotype
OT  - Nutrigenetics
OT  - Precision nutrition
OT  - Single nucleotide polymorphism
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2024/03/11 06:42
MHDA- 2024/03/11 06:43
PMCR- 2024/02/15
CRDT- 2024/03/11 04:34
PHST- 2023/10/14 00:00 [received]
PHST- 2023/12/07 00:00 [revised]
PHST- 2024/01/11 00:00 [accepted]
PHST- 2024/03/11 06:43 [medline]
PHST- 2024/03/11 06:42 [pubmed]
PHST- 2024/03/11 04:34 [entrez]
PHST- 2024/02/15 00:00 [pmc-release]
AID - 10.4239/wjd.v15.i2.142 [doi]
PST - ppublish
SO  - World J Diabetes. 2024 Feb 15;15(2):142-153. doi: 10.4239/wjd.v15.i2.142.