PMID- 38464370
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240312
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 15
IP  - 2
DP  - 2024 Feb 15
TI  - Identification of hub genes associated with Helicobacter pylori infection and 
      type 2 diabetes mellitus: A pilot bioinformatics study.
PG  - 170-185
LID - 10.4239/wjd.v15.i2.170 [doi]
AB  - BACKGROUND: Helicobacter pylori (H. pylori) infection is related to various 
      extragastric diseases including type 2 diabetes mellitus (T2DM). However, the 
      possible mechanisms connecting H. pylori infection and T2DM remain unknown. AIM: 
      To explore potential molecular connections between H. pylori infection and T2DM. 
      METHODS: We extracted gene expression arrays from three online datasets 
      (GSE60427, GSE27411 and GSE115601). Differentially expressed genes (DEGs) 
      commonly present in patients with H. pylori infection and T2DM were identified. 
      Hub genes were validated using human gastric biopsy samples. Correlations between 
      hub genes and immune cell infiltration, miRNAs, and transcription factors (TFs) 
      were further analyzed. RESULTS: A total of 67 DEGs were commonly presented in 
      patients with H. pylori infection and T2DM. Five significantly upregulated hub 
      genes, including TLR4, ITGAM, C5AR1, FCER1G, and FCGR2A, were finally identified, 
      all of which are closely related to immune cell infiltration. The gene-miRNA 
      analysis detected 13 miRNAs with at least two gene cross-links. TF-gene 
      interaction networks showed that TLR4 was coregulated by 26 TFs, the largest 
      number of TFs among the 5 hub genes. CONCLUSION: We identified five hub genes 
      that may have molecular connections between H. pylori infection and T2DM. This 
      study provides new insights into the pathogenesis of H. pylori-induced onset of 
      T2DM.
CI  - (c)The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Chen, Han
AU  - Chen H
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210003, Jiangsu Province, China.
FAU - Zhang, Guo-Xin
AU  - Zhang GX
AD  - Department of Gastroenterology, Jiangsu Province Hospital, Nanjing 210029, 
      Jiangsu Province, China.
FAU - Zhou, Xiao-Ying
AU  - Zhou XY
AD  - Department of Gastroenterology, Jiangsu Province Hospital, Nanjing 210029, 
      Jiangsu Province, China. zhouxiaoying0926@njmu.edu.cn.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10921168
OTO - NOTNLM
OT  - Bioinformatics analysis
OT  - Differentially expressed genes
OT  - Helicobacter pylori
OT  - Hub genes
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: The authors declare no potential conflicts of 
      interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2024/03/11 06:43
MHDA- 2024/03/11 06:44
PMCR- 2024/02/15
CRDT- 2024/03/11 04:34
PHST- 2023/09/21 00:00 [received]
PHST- 2023/11/21 00:00 [revised]
PHST- 2023/12/27 00:00 [accepted]
PHST- 2024/03/11 06:44 [medline]
PHST- 2024/03/11 06:43 [pubmed]
PHST- 2024/03/11 04:34 [entrez]
PHST- 2024/02/15 00:00 [pmc-release]
AID - 10.4239/wjd.v15.i2.170 [doi]
PST - ppublish
SO  - World J Diabetes. 2024 Feb 15;15(2):170-185. doi: 10.4239/wjd.v15.i2.170.