PMID- 38466406 OWN - NLM STAT- MEDLINE DCOM- 20240327 LR - 20240327 IS - 2731-7013 (Electronic) IS - 2731-7005 (Linking) VI - 75 IP - 4 DP - 2024 Apr TI - [Spontaneous remission of urticaria: does it exist and if so, when?]. PG - 303-308 LID - 10.1007/s00105-024-05320-z [doi] AB - BACKGROUND: Urticaria mostly occurs acutely with a very high probability of spontaneous remission. When it persists for more than 6 weeks a chronic urticaria is manifest, which occurs either spontaneously or inducible by specific triggers. The underlying mechanisms are not fully understood but recent research points to defined pathogenetic factors. QUESTION AND AIM: Whether spontaneous remission is possible in urticaria is summarized descriptively in this review, and suggestions are given for the "step down" of urticaria treatment after remission. The mechanisms including autoallergic, immunoglobulin E (IgE)-dependent type I reactions and autoimmune, activating IgG-dependent type IIb reactions are presented. These are discussed in the context of spontaneous remission and the possibilities of induced remission. CI - (c) 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. FAU - Sulk, Mathias AU - Sulk M AD - Klinik fur Hautkrankheiten, Universitatsklinikum Munster, Munster, Deutschland. FAU - Hammers, Christoph M AU - Hammers CM AD - Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Regensburg, Regensburg, Deutschland. FAU - Heine, Guido AU - Heine G AD - Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland. gheine@dermatology.uni-kiel.de. LA - ger PT - English Abstract PT - Journal Article PT - Review TT - Spontanremission der Urtikaria: Gibt es das, und wenn ja, wann? DEP - 20240311 PL - Germany TA - Dermatologie (Heidelb) JT - Dermatologie (Heidelberg, Germany) JID - 9918384885206676 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - Remission, Spontaneous MH - Chronic Disease MH - *Urticaria/diagnosis MH - *Chronic Urticaria/drug therapy MH - Immunoglobulin E OTO - NOTNLM OT - Allergy OT - Antihistamines OT - Autoimmunity OT - Chronicity OT - System therapy EDAT- 2024/03/11 18:42 MHDA- 2024/03/27 06:43 CRDT- 2024/03/11 12:13 PHST- 2024/02/06 00:00 [accepted] PHST- 2024/03/27 06:43 [medline] PHST- 2024/03/11 18:42 [pubmed] PHST- 2024/03/11 12:13 [entrez] AID - 10.1007/s00105-024-05320-z [pii] AID - 10.1007/s00105-024-05320-z [doi] PST - ppublish SO - Dermatologie (Heidelb). 2024 Apr;75(4):303-308. doi: 10.1007/s00105-024-05320-z. Epub 2024 Mar 11.