PMID- 38467496
OWN - NLM
STAT- MEDLINE
DCOM- 20240313
LR  - 20240321
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 44
IP  - 3
DP  - 2024 Mar 12
TI  - Acupotomy combined with metformin hydrochloride tablet for type 2 diabetes 
      mellitus and its effect on serum inflammatory factors.
PG  - 245-250
LID - 10.13703/j.0255-2930.20230705-k0002 [doi]
AB  - OBJECTIVES: To observe the clinical efficacy of acupotomy combined with metformin 
      hydrochloride tablet for type 2 diabetes mellitus (T2DM) and its effect on serum 
      levels of inflammatory factors. METHODS: A total of 68 patients with T2DM were 
      randomized into an acupotomy group (34 cases, 2 cases dropped out) and a western 
      medication group (34 cases, 2 cases dropped out). Metformin hydrochloride tablet 
      was given orally in the western medication group, 0.5-1 g each time, twice a day, 
      for continuous 8 weeks. On the basis of the treatment in the western medication 
      group, acupotomy was applied at bilateral Geshu (BL 17), Weiwanxiashu (EX-B 3), 
      Ganshu (BL 18) in the acupotomy group, once a week for continuous 8 weeks. Before 
      and after treatment, in the two groups, blood glucose (fasting blood glucose 
      [FBG], 2-hour plasma glucose [2 h PG] and glycosylated hemoglobin [HbA1c]), TCM 
      syndrome score, blood lipids (total cholesterol [TC], triglyceride [TG], low 
      density lipoprotein cholesterol [LDL-C] and high density lipoprotein cholesterol 
      [HDL-C]), insulin (fasting insulin [FINS] and 2-hour insulin [2 h INS]), 
      C-peptide indexes (fasting C-peptide [FC-P] and 2-hour C-peptide [2 h C-P]), 
      dosage of metformin hydrochloride tablet and diabetes specific quality of life 
      (DSQL) score were observed, the serum levels of tumor necrosis factor (TNF)-alpha, 
      interleukin (IL)-6 and IL-17 were measured by ELISA. RESULTS: After treatment, 
      the FBG, 2 h PG, HbA1c, TCM syndrome scores, TC, TG, LDL-C, FINS, 2 h INS, FC-P, 
      2 h C-P, DSQL scores as well as the serum levels of TNF-alpha, IL-6, IL-17 were 
      decreased compared with those before treatment (P<0.01), HDL-C was increased 
      compared with that before treatment (P<0.01) in the two groups; the dosage of 
      metformin hydrochloride tablet was decreased compared with that before treatment 
      in the acupotomy group (P<0.01). After treatment, in the acupotomy group, the 
      FBG, HbA1c, TCM syndrome score, TC, TG, LDL-C, FINS, 2 h INS, FC-P, 2 h C-P, 
      dosage of metformin hydrochloride tablet, DSQL score as well as the serum level 
      of TNF-alpha were lower than those in the western medication group (P<0.05). 
      CONCLUSIONS: Acupotomy combined with metformin hydrochloride tablet can improve 
      the blood glucose, clinical symptoms and quality of life in patients with T2DM, 
      its mechanism may be related to the regulation of inflammatory reaction.
FAU - Zhu, Tao
AU  - Zhu T
AD  - College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 
      611137, Sichuan Province, China. 873678395@qq.com.
FAU - Ji, Laixi
AU  - Ji L
AD  - Second Clinical College, Shanxi University of CM.
FAU - Gao, Zhen
AU  - Gao Z
AD  - Second Clinical College, Shanxi University of CM.
FAU - Ren, Jia
AU  - Ren J
AD  - Second Clinical College, Shanxi University of CM.
FAU - Ji, Yufang
AU  - Ji Y
AD  - Second Clinical College, Shanxi University of CM.
FAU - Miao, Jinling
AU  - Miao J
AD  - Fourth Department of Acupuncture and Moxibustion, Shanxi Acupuncture-Moxibustion 
      Hospital, Taiyuan 030006. 475241908@qq.com.
LA  - eng
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - 针刀联合盐酸二甲双胍片治疗2型糖尿病的临床疗效及对血清炎性因子含量的影响.
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Interleukin-17)
RN  - 9100L32L2N (Metformin)
RN  - 0 (Tablets)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - *Acupuncture Therapy
MH  - Blood Glucose
MH  - C-Peptide
MH  - Cholesterol, LDL
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Glycated Hemoglobin
MH  - Interleukin-17
MH  - *Metformin/therapeutic use
MH  - Quality of Life
MH  - Tablets/therapeutic use
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - acupotomy
OT  - inflammatory reaction
OT  - metformin hydrochloride tablet
OT  - randomized controlled trial (RCT)
OT  - type 2 diabetes mellitus
EDAT- 2024/03/12 00:42
MHDA- 2024/03/13 06:46
CRDT- 2024/03/11 22:23
PHST- 2024/03/13 06:46 [medline]
PHST- 2024/03/12 00:42 [pubmed]
PHST- 2024/03/11 22:23 [entrez]
AID - 10.13703/j.0255-2930.20230705-k0002 [doi]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2024 Mar 12;44(3):245-250. doi: 
      10.13703/j.0255-2930.20230705-k0002.