PMID- 38467984
OWN - NLM
STAT- MEDLINE
DCOM- 20240313
LR  - 20240313
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1444
DP  - 2024
TI  - HLA Genetics for the Human Diseases.
PG  - 237-258
LID - 10.1007/978-981-99-9781-7_16 [doi]
AB  - Highly polymorphic human leukocyte antigen (HLA) molecules (alleles) expressed by 
      different classical HLA class I and class II genes have crucial roles in the 
      regulation of innate and adaptive immune responses, transplant rejection and in 
      the pathogenesis of numerous infectious and autoimmune diseases. To date, over 
      35,000 HLA alleles have been published from the IPD-IMGT/HLA database, and 
      specific HLA alleles and HLA haplotypes have been reported to be associated with 
      more than 100 different diseases and phenotypes. Next generation sequencing (NGS) 
      technology developed in recent years has provided breakthroughs in various HLA 
      genomic/gene studies and transplant medicine. In this chapter, we review the 
      current information on the HLA genomic structure and polymorphisms, as well as 
      the genetic context in which numerous disease associations have been identified 
      in this region.
CI  - (c) 2024. The Author(s), under exclusive license to Springer Nature Singapore Pte 
      Ltd.
FAU - Shiina, Takashi
AU  - Shiina T
AD  - Tokai University School of Medicine, Isehara, Japan. 
      tshiina@is.icc.u-tokai.ac.jp.
FAU - Kulski, Jerzy K
AU  - Kulski JK
AD  - Tokai University School of Medicine, Isehara, Japan.
AD  - School of Biomedical Sciences, The University of Western Australia, Nedlands, 
      Western Australia, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Humans
MH  - *Histocompatibility Antigens Class I/genetics
MH  - *HLA Antigens/genetics
MH  - Polymorphism, Genetic
MH  - Histocompatibility Antigens Class II/genetics
MH  - Haplotypes
MH  - Alleles
OTO - NOTNLM
OT  - Allele
OT  - Disease association
OT  - Gene expression
OT  - Haplotype
OT  - Human leukocyte antigen
OT  - Major histocompatibility complex
OT  - Next generation sequencing
OT  - Polymorphism
OT  - Transposable element
EDAT- 2024/03/12 06:42
MHDA- 2024/03/13 06:46
CRDT- 2024/03/12 00:43
PHST- 2024/03/13 06:46 [medline]
PHST- 2024/03/12 06:42 [pubmed]
PHST- 2024/03/12 00:43 [entrez]
AID - 10.1007/978-981-99-9781-7_16 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2024;1444:237-258. doi: 10.1007/978-981-99-9781-7_16.