PMID- 38468345
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240314
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 16
IP  - 1
DP  - 2024 Mar 12
TI  - Epidemiological and transcriptome data identify shared gene signatures and immune 
      cell infiltration in type 2 diabetes and non-small cell lung cancer.
PG  - 64
LID - 10.1186/s13098-024-01278-z [doi]
LID - 64
AB  - BACKGROUND: Numerous previous studies have reported an association between type 2 
      diabetes mellitus (T2DM) and lung cancer risk, but the underlying mechanism of 
      the interaction remains unclear. This study aimed to investigate the shared 
      genetic features and immune infiltration processes between lung cancer and T2DM. 
      METHODS: Epidemiological data from the National Health and Nutrition Examination 
      Survey (NHANES) 2000-2018 was used to explore the relationship between lung 
      cancer and diabetes systematically. In addition, we also used bioinformatics 
      methods to analyze the transcriptome data from the Gene Expression Omnibus (GEO) 
      to explore the potential functional mechanisms from the perspective of genes and 
      immune infiltration. RESULTS: Logistic regression analysis showed that 
      prediabetes (OR = 3.289,95%CI 1.231, 8.788, p = 0.01760, model 3)and type 2 
      diabetes (OR = 3.032 95%CI,1.015, 9.054, p = 0.04689) were significantly 
      associated with an increased risk of lung cancer after adjusting for multiple 
      covariates. Data from NHANES showed an inverted U-shaped relationship between 
      fasting blood glucose and glycosylated haemoglobin and the risk of lung cancer (P 
      for non-linear < 0.001). Transcriptome data showed that we screened 57 co-DEGs, 
      of which 25 were up-regulated co-DEGs and 32 were down-regulated. Ten core DEGs 
      were identified by bioinformatics analysis, which were SMC6, CDC27, CDC7, 
      RACGAP1, SMC4, NCF4, NCF1, NCF2, SELPLG and CFP. Correlation analysis showed that 
      some core DEGs were significantly associated with simultaneous dysregulation of 
      immune cells. CONCLUSION: The identified core genes of NSCLC and T2DM are 
      associated with dysregulated immune cells, which provides a potential research 
      avenue for diagnosing and treating lung cancer combined with diabetes.
CI  - (c) 2024. The Author(s).
FAU - Yuan, Qian
AU  - Yuan Q
AD  - Department of Thoracic surgery, Nan Jing Gaochun people's Hospital (The Gaochun 
      Affiliated Hospital of Jiang Su University), 210000, Nanjing, Jiangsu, China.
FAU - Li, Long
AU  - Li L
AD  - Department of Thoracic surgery, Nan Jing Gaochun people's Hospital (The Gaochun 
      Affiliated Hospital of Jiang Su University), 210000, Nanjing, Jiangsu, China.
FAU - Wang, Liu-Shun
AU  - Wang LS
AD  - Department of Thoracic surgery, Nan Jing Gaochun people's Hospital (The Gaochun 
      Affiliated Hospital of Jiang Su University), 210000, Nanjing, Jiangsu, China.
FAU - Xing, Shi-Gui
AU  - Xing SG
AD  - Department of Thoracic surgery, Nan Jing Gaochun people's Hospital (The Gaochun 
      Affiliated Hospital of Jiang Su University), 210000, Nanjing, Jiangsu, China. 
      gcxw5988@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240312
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC10929160
OTO - NOTNLM
OT  - Bioinformatics analysis
OT  - Immune cell infiltration
OT  - Lung cancer
OT  - NHANES
OT  - Type 2 diabetes mellitus
COIS- The authors declare no competing interests.
EDAT- 2024/03/12 06:42
MHDA- 2024/03/12 06:43
PMCR- 2024/03/12
CRDT- 2024/03/12 01:21
PHST- 2023/11/06 00:00 [received]
PHST- 2024/01/25 00:00 [accepted]
PHST- 2024/03/12 06:43 [medline]
PHST- 2024/03/12 06:42 [pubmed]
PHST- 2024/03/12 01:21 [entrez]
PHST- 2024/03/12 00:00 [pmc-release]
AID - 10.1186/s13098-024-01278-z [pii]
AID - 1278 [pii]
AID - 10.1186/s13098-024-01278-z [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2024 Mar 12;16(1):64. doi: 10.1186/s13098-024-01278-z.