PMID- 38470548
OWN - NLM
STAT- Publisher
LR  - 20240312
IS  - 1559-0097 (Electronic)
IS  - 1046-3976 (Linking)
DP  - 2024 Mar 12
TI  - Molecular Classification of Gastrointestinal and Pancreatic Neuroendocrine 
      Neoplasms: Are We Ready for That?
LID - 10.1007/s12022-024-09807-2 [doi]
AB  - In the last two decades, the increasing availability of technologies for 
      molecular analyses has allowed an insight in the genomic alterations of 
      neuroendocrine neoplasms (NEN) of the gastrointestinal tract and pancreas. This 
      knowledge has confirmed, supported, and informed the pathological classification 
      of NEN, clarifying the differences between neuroendocrine carcinomas (NEC) and 
      neuroendocrine tumors (NET) and helping to define the G3 NET category. At the 
      same time, the identification genomic alterations, in terms of gene mutation, 
      structural abnormalities, and epigenetic changes differentially involved in the 
      pathogenesis of NEC and NET has identified potential molecular targets for 
      precision therapy. This review critically recapitulates the available molecular 
      features of digestive NEC and NET, highlighting their correlates with 
      pathological aspects and clinical characteristics of these neoplasms and revising 
      their role as predictive biomarkers for targeted therapy. In this context, the 
      feasibility and applicability of a molecular classification of gastrointestinal 
      and pancreatic NEN will be explored.
CI  - (c) 2024. The Author(s).
FAU - Uccella, Silvia
AU  - Uccella S
AUID- ORCID: 0000-0002-5714-7295
AD  - Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 
      4, 20072, Pieve Emanuele, Milan, Italy. silvia.uccella@hunimed.eu.
AD  - Pathology Service IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, 
      Rozzano, Milan, Italy. silvia.uccella@hunimed.eu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240312
PL  - United States
TA  - Endocr Pathol
JT  - Endocrine pathology
JID - 9009288
SB  - IM
OTO - NOTNLM
OT  - Genetics
OT  - Molecular classification
OT  - Neuroendocrine carcinoma
OT  - Neuroendocrine neoplasm
OT  - Neuroendocrine tumor
OT  - Target therapy
EDAT- 2024/03/12 18:42
MHDA- 2024/03/12 18:42
CRDT- 2024/03/12 12:16
PHST- 2024/02/29 00:00 [accepted]
PHST- 2024/03/12 18:42 [medline]
PHST- 2024/03/12 18:42 [pubmed]
PHST- 2024/03/12 12:16 [entrez]
AID - 10.1007/s12022-024-09807-2 [pii]
AID - 10.1007/s12022-024-09807-2 [doi]
PST - aheadofprint
SO  - Endocr Pathol. 2024 Mar 12. doi: 10.1007/s12022-024-09807-2.