PMID- 38471134
OWN - NLM
STAT- MEDLINE
DCOM- 20240314
LR  - 20240314
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 46
IP  - 1
DP  - 2024 Dec 31
TI  - Chronic exercise improves renal AT(1) and ETB receptor functions via modulating 
      GRK4 expression in obese Zucker rats.
PG  - 2323532
LID - 10.1080/10641963.2024.2323532 [doi]
AB  - BACKGROUND: Physical activity has profound benefits on health, especially in 
      patients with cardiovascular and metabolic disease. Exercise training can reduce 
      oxidative stress, improve renal function, and thus lower blood pressure. However, 
      the effect of exercise training on angiotensin II type 1 receptors (AT(1)R) and 
      endothelin subtype B receptors (ETBR)-mediated diuresis and natriuresis in obese 
      Zucker rats is unclear. METHODS: Lean and obese Zucker rats were exercised or 
      placed on a nonmoving treadmill for 8 weeks. Blood pressure was measured by 
      tail-cuff plethysmography, and functions of AT(1)R and ETBR in the kidney were 
      measured by natriuresis, respectively. RESULTS: Our data showed that exercise 
      training improved glucose and lipid metabolism, renal function and sodium 
      excretion in obese Zucker rats, accompanied by decreased oxidative stress and 
      GRK4 expression in obese Zucker rats. Moreover, exercise training reduced the 
      Candesartan-induced an increase in diuresis and natriuresis and increased ETBR 
      agonists (BQ3020)-mediated diuresis and natriuresis in obese Zucker rats, which 
      were associated with decreased renal AT(1)R expression and ETBR phosphorylation 
      levels. CONCLUSIONS: The results demonstrate that exercise training lowers blood 
      pressure via improving renal AT(1)R and ETBR function through modulating GRK4 
      expression in Obese Zucker Rats and provides potentially effective targets for 
      obesity-related hypertension.
FAU - Lu, Jingjing
AU  - Lu J
AD  - The Second Clinical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong, China.
AD  - Guangzhou University of Chinese Medicine, Guangzhou, China.
AD  - Department of Nephrology, The Secondary Affiliated Hospital of Guizhou University 
      of Traditional Chinese Medicine, Guiyang, China.
FAU - Li, Zhengsheng
AU  - Li Z
AD  - Department of Nephrology, The Secondary Affiliated Hospital of Guizhou University 
      of Traditional Chinese Medicine, Guiyang, China.
FAU - Yang, Yinan
AU  - Yang Y
AD  - Department of Nephrology, The Secondary Affiliated Hospital of Guizhou University 
      of Traditional Chinese Medicine, Guiyang, China.
FAU - Wei, Fangning
AU  - Wei F
AD  - The Second Clinical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong, China.
AD  - Guangzhou University of Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20240312
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - EC 2.7.11.16 (GRK4 protein, human)
RN  - EC 2.7.11.16 (G-Protein-Coupled Receptor Kinase 4)
SB  - IM
MH  - Humans
MH  - Rats
MH  - Animals
MH  - Rats, Zucker
MH  - *Kidney/metabolism
MH  - *Hypertension
MH  - Obesity/complications
MH  - Blood Pressure
MH  - G-Protein-Coupled Receptor Kinase 4/metabolism
OTO - NOTNLM
OT  - Exercise
OT  - GRK4
OT  - angiotensin II type 1 receptor
OT  - endothelin subtype B receptor
OT  - hypertension
OT  - obesity
EDAT- 2024/03/12 18:42
MHDA- 2024/03/14 06:47
CRDT- 2024/03/12 17:43
PHST- 2024/03/14 06:47 [medline]
PHST- 2024/03/12 18:42 [pubmed]
PHST- 2024/03/12 17:43 [entrez]
AID - 10.1080/10641963.2024.2323532 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2024 Dec 31;46(1):2323532. doi: 
      10.1080/10641963.2024.2323532. Epub 2024 Mar 12.