PMID- 38472748
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240315
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 13
IP  - 5
DP  - 2024 Feb 20
TI  - Development of a Cation Exchange SPE-HILIC-MS/MS Method for the Determination of 
      Ningnanmycin Residues in Tea and Chrysanthemum.
LID - 10.3390/foods13050635 [doi]
LID - 635
AB  - Ningnanmycin is a widely used antibiotic in agricultural production that 
      effectively controls fungal and viral diseases in tea trees and chrysanthemums. 
      The polarity characteristic of ningnanmycin has posed limitations on the 
      development of robust detection methods, thereby hindering effective monitoring 
      and control measures. By combining cation exchange solid phase extraction (SPE) 
      with hydrophilic interaction chromatography tandem mass spectrometry 
      (HILIC-MS/MS), we have effectively tackled the issue pertaining to the separation 
      and retention of ningnanmycin. The average recoveries of ningnanmycin in green 
      tea, black tea, and chrysanthemum were 77.3-82.0%, 80.1-81.5%, and 74.0-80.0%, 
      respectively. The intraday and interday relative standard deviations (RSDs) were 
      below and equal to 7.7%. Good linearity was observed in the concentration range 
      of 1-1000 mug/L (R2 > 0.998). The limits of detection (LODs) ranged from 1.1 mug/kg 
      to 7.1 mug/kg, and the limits of quantification (LOQs) ranged from 3.6 mug/kg to 
      23.7 mug/kg for ningnanmycin. These results indicate the good accuracy, 
      repeatability, reproducibility, and sensitivity of the method. It is suitable for 
      detecting ningnanmycin in tea and chrysanthemum.
FAU - Li, Aiping
AU  - Li A
AD  - Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 
      310008, China.
AD  - Graduate School of Chinese Academy of Agricultural Sciences, Beijing 100081, 
      China.
FAU - Wang, Chen
AU  - Wang C
AD  - Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 
      310008, China.
AD  - Laboratory of Quality and Safety Risk Assessment for Tea Products (Hangzhou), 
      Ministry of Agriculture and Rural Affairs, Hangzhou 310008, China.
AD  - Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture and 
      Rural Affairs, Hangzhou 310008, China.
FAU - Wu, Zhenghao
AU  - Wu Z
AD  - Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 
      310008, China.
AD  - Graduate School of Chinese Academy of Agricultural Sciences, Beijing 100081, 
      China.
FAU - Liu, Yingying
AU  - Liu Y
AD  - Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 
      310008, China.
AD  - Graduate School of Chinese Academy of Agricultural Sciences, Beijing 100081, 
      China.
FAU - Hao, Zhenxia
AU  - Hao Z
AD  - Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 
      310008, China.
AD  - Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture and 
      Rural Affairs, Hangzhou 310008, China.
FAU - Lu, Chengyin
AU  - Lu C
AD  - Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 
      310008, China.
AD  - Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture and 
      Rural Affairs, Hangzhou 310008, China.
FAU - Chen, Hongping
AU  - Chen H
AD  - Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 
      310008, China.
AD  - Laboratory of Quality and Safety Risk Assessment for Tea Products (Hangzhou), 
      Ministry of Agriculture and Rural Affairs, Hangzhou 310008, China.
AD  - Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture and 
      Rural Affairs, Hangzhou 310008, China.
LA  - eng
GR  - LGC22B070007/Zhejiang Province Basic Public Welfare Research Plan Public Welfare 
      Project/
GR  - CAAS-ASTIP-2016-TRICAAS/Tea Quality Risk Assessment Innovative Research Team in 
      Chinese Academy of Agricultural Sciences/
GR  - No. CARS-19/Modern Agro Industry Technology Research System/
PT  - Journal Article
DEP - 20240220
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC10930893
OTO - NOTNLM
OT  - HILIC-MS/MS
OT  - cation exchange
OT  - chrysanthemum
OT  - ningnanmycin
OT  - tea
COIS- The authors declare no conflict of interest.
EDAT- 2024/03/13 06:47
MHDA- 2024/03/13 06:48
PMCR- 2024/02/20
CRDT- 2024/03/13 01:16
PHST- 2024/01/10 00:00 [received]
PHST- 2024/02/13 00:00 [revised]
PHST- 2024/02/14 00:00 [accepted]
PHST- 2024/03/13 06:48 [medline]
PHST- 2024/03/13 06:47 [pubmed]
PHST- 2024/03/13 01:16 [entrez]
PHST- 2024/02/20 00:00 [pmc-release]
AID - foods13050635 [pii]
AID - foods-13-00635 [pii]
AID - 10.3390/foods13050635 [doi]
PST - epublish
SO  - Foods. 2024 Feb 20;13(5):635. doi: 10.3390/foods13050635.