PMID- 38473284
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240315
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 16
IP  - 5
DP  - 2024 Feb 25
TI  - C-Reactive Protein-to-Albumin Ratio to Predict Tolerability of S-1 as an Adjuvant 
      Chemotherapy in Pancreatic Cancer.
LID - 10.3390/cancers16050922 [doi]
LID - 922
AB  - Adjuvant chemotherapy (AC) with S-1 after radical surgery for resectable 
      pancreatic cancer (PC) has shown a significant survival advantage over surgery 
      alone. Consequently, ensuring that patients receive a consistent, uninterrupted 
      S-1 regimen is of paramount importance. This study aimed to investigate whether 
      the C-reactive protein-to-albumin ratio (CAR) could predict S-1 AC completion in 
      PC patients without dropout due to adverse events (AEs). We retrospectively 
      enrolled 95 patients who underwent radical pancreatectomy and S-1 AC for PC 
      between January 2010 and December 2022. A statistical analysis was conducted to 
      explore the correlation of predictive markers with S-1 completion, defined as 
      continuous oral administration for 6 months. Among the 95 enrolled patients, 66 
      (69.5%) completed S-1, and 29 (30.5%) failed. Receiver operating characteristic 
      curve analysis revealed 0.05 as the optimal CAR threshold to predict S-1 
      completion. Univariate and multivariate analyses further validated that a CAR >/= 
      0.05 was independently correlated with S-1 completion (p < 0.001 and p = 0.006, 
      respectively). Furthermore, a significant association was established between a 
      higher CAR at initiation of oral administration and acceptable recurrence-free 
      and overall survival (p = 0.003 and p < 0.001, respectively). CAR >/= 0.05 serves 
      as a predictive marker for difficulty in completing S-1 treatment as AC for PC 
      due to AEs.
FAU - Funamizu, Naotake
AU  - Funamizu N
AUID- ORCID: 0000-0001-6076-6516
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Sakamoto, Akimasa
AU  - Sakamoto A
AUID- ORCID: 0000-0001-8042-1486
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Hikida, Takahiro
AU  - Hikida T
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Ito, Chihiro
AU  - Ito C
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Shine, Mikiya
AU  - Shine M
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Nishi, Yusuke
AU  - Nishi Y
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Uraoka, Mio
AU  - Uraoka M
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Nagaoka, Tomoyuki
AU  - Nagaoka T
AUID- ORCID: 0000-0002-7635-9955
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Honjo, Masahiko
AU  - Honjo M
AUID- ORCID: 0000-0001-9642-4155
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Tamura, Kei
AU  - Tamura K
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Sakamoto, Katsunori
AU  - Sakamoto K
AUID- ORCID: 0000-0002-6431-0011
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Ogawa, Kohei
AU  - Ogawa K
AUID- ORCID: 0000-0002-5672-6308
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
FAU - Takada, Yasutsugu
AU  - Takada Y
AUID- ORCID: 0000-0001-9743-1840
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Ehime University Graduate School 
      of Medicine, Toon 791-0295, Japan.
LA  - eng
PT  - Journal Article
DEP - 20240225
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10931362
OTO - NOTNLM
OT  - C-reactive protein-to-albumin ratio
OT  - S-1
OT  - adjuvant chemotherapy
OT  - malnutrition
OT  - pancreatic cancer
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/13 06:47
MHDA- 2024/03/13 06:48
PMCR- 2024/02/25
CRDT- 2024/03/13 01:19
PHST- 2024/02/05 00:00 [received]
PHST- 2024/02/19 00:00 [revised]
PHST- 2024/02/23 00:00 [accepted]
PHST- 2024/03/13 06:48 [medline]
PHST- 2024/03/13 06:47 [pubmed]
PHST- 2024/03/13 01:19 [entrez]
PHST- 2024/02/25 00:00 [pmc-release]
AID - cancers16050922 [pii]
AID - cancers-16-00922 [pii]
AID - 10.3390/cancers16050922 [doi]
PST - epublish
SO  - Cancers (Basel). 2024 Feb 25;16(5):922. doi: 10.3390/cancers16050922.