PMID- 38473807
OWN - NLM
STAT- MEDLINE
DCOM- 20240314
LR  - 20240315
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 5
DP  - 2024 Feb 22
TI  - Could MMP3 and MMP9 Serve as Biomarkers in EBV-Related Oropharyngeal Cancer.
LID - 10.3390/ijms25052561 [doi]
LID - 2561
AB  - The high incidence of, and mortality from, head and neck cancers (HNCs), 
      including those related to Epstein-Barr virus (EBV), constitute a major challenge 
      for modern medicine, both in terms of diagnosis and treatment. Therefore, many 
      researchers have made efforts to identify diagnostic and prognostic factors. The 
      aim of this study was to evaluate the diagnostic usefulness of matrix 
      metalloproteinase 3 (MMP 3) and matrix metalloproteinase 9 (MMP 9) in EBV 
      positive oropharyngeal squamous cell carcinoma (OPSCC) patients. For this 
      purpose, the level of these MMPs in the serum of patients with EBV-positive OPSCC 
      was analyzed in relation to the degree of histological differentiation and TNM 
      classification. Our research team's results indicate that the level of both MMPs 
      is much higher in the EBV positive OPSCC patients compared to the EBV negative 
      and control groups. Moreover, their levels were higher in more advanced clinical 
      stages. Considering the possible correlation between the level of MMP 3, MMP 9 
      and anti-EBV antibodies, and also viral load, after statistical analysis using 
      multiple linear regression, their high correlation was demonstrated. The obtained 
      results confirm the diagnostic accuracy for MMP 3 and MMP 9. Both MMPs may be 
      useful in the diagnosis of EBV positive OPSCC patients.
FAU - Polz, Anna
AU  - Polz A
AD  - Genomed S.A., 02-971 Warsaw, Poland.
FAU - Morshed, Kamal
AU  - Morshed K
AUID- ORCID: 0000-0003-0061-0362
AD  - Department of Otolaryngology Head and Neck Cancer, University of Technology and 
      Humanities in Radom, 26-600 Radom, Poland.
FAU - Drop, Bartlomiej
AU  - Drop B
AD  - Department of Computer Science and Medical Statistics with e-health Laboratory, 
      Medical University of Lublin, 20-090 Lublin, Poland.
FAU - Polz-Dacewicz, Malgorzata
AU  - Polz-Dacewicz M
AUID- ORCID: 0000-0002-3222-184X
AD  - Department of Virology with Viral Diagnostics Laboratory, Medical University of 
      Lublin, 20-093 Lublin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20240222
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.35 (MMP9 protein, human)
SB  - IM
MH  - Humans
MH  - Herpesvirus 4, Human
MH  - Matrix Metalloproteinase 3
MH  - Matrix Metalloproteinase 9
MH  - *Epstein-Barr Virus Infections
MH  - *Carcinoma, Squamous Cell/diagnosis
MH  - *Head and Neck Neoplasms
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Biomarkers
MH  - *Oropharyngeal Neoplasms/pathology
PMC - PMC10931672
OTO - NOTNLM
OT  - EBV
OT  - MMP 9
OT  - MMP3
OT  - biomarkers
OT  - oropharyngeal cancer
COIS- Author Anna Polz was employed by the company Genomed S.A. The remaining authors 
      declare that the research was conducted in the absence of any commercial or 
      financial relationships that could be construed as a potential conflict of 
      interest.
EDAT- 2024/03/13 06:47
MHDA- 2024/03/14 06:47
PMCR- 2024/02/22
CRDT- 2024/03/13 01:22
PHST- 2024/02/10 00:00 [received]
PHST- 2024/02/18 00:00 [revised]
PHST- 2024/02/20 00:00 [accepted]
PHST- 2024/03/14 06:47 [medline]
PHST- 2024/03/13 06:47 [pubmed]
PHST- 2024/03/13 01:22 [entrez]
PHST- 2024/02/22 00:00 [pmc-release]
AID - ijms25052561 [pii]
AID - ijms-25-02561 [pii]
AID - 10.3390/ijms25052561 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Feb 22;25(5):2561. doi: 10.3390/ijms25052561.