PMID- 38473936
OWN - NLM
STAT- MEDLINE
DCOM- 20240314
LR  - 20240315
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 5
DP  - 2024 Feb 26
TI  - Oral Ingestion of Yuzu Seed Oil Suppresses the Development of Atopic 
      Dermatitis-like Skin Lesions in NC/Nga Mice.
LID - 10.3390/ijms25052689 [doi]
LID - 2689
AB  - Long-term oral ingestion of unheated yuzu seed oil in humans reduces lipid 
      peroxides in the blood. Moreover, yuzu seed oil contains limonin, which can 
      induce antioxidant and anti-inflammatory effects by activating the transcription 
      factor nuclear factor erythroid 2-related factor 2 (Nrf2). Previously, Nrf2 has 
      been shown to reduce atopic dermatitis (AD). Therefore, we hypothesized that 
      ingesting unheated yuzu seed oil can regulate AD through Nrf2. An AD model was 
      established using NC/Nga mice through repeated local exposure to mite antigens. 
      Unheated and purified yuzu seed oil (100 microL/mice) or water (control, 100 microL/mice) 
      was administered orally once a day using a gastric cannula for rodents for 28 
      days. On day 28, mice in the unheated yuzu seed oil group exhibited significantly 
      lower clinical skin severity scores and ear thickness than those in the purified 
      yuzu seed oil and water groups. Serum histamine levels remained unaltered among 
      the three AD-induced groups. Serum Dermatophagoides farina body (Dfb)-specific 
      immunoglobulin E (IgE) levels were significantly lower in the unheated yuzu seed 
      oil group. Oral ingestion of yuzu seed oil in NC/Nga AD model mice significantly 
      suppressed dermatitis deterioration and decreased serum IgE levels. Clinical 
      trials (n = 41) have already confirmed that unheated yuzu oil is safe for 
      long-term intake, further suggesting its potential use in improving AD symptoms.
FAU - Asano, Kimito
AU  - Asano K
AD  - Kochi-Umajimura Yuzu Health Research Course, Kochi Medical School, Kochi 
      University, Nankoku 783-8505, Japan.
AD  - Umajimura Agricultural Cooperative, Kochi 781-6201, Japan.
FAU - Watanabe, Yoshiya
AU  - Watanabe Y
AD  - Kochi-Umajimura Yuzu Health Research Course, Kochi Medical School, Kochi 
      University, Nankoku 783-8505, Japan.
FAU - Miyamoto, Mio
AU  - Miyamoto M
AUID- ORCID: 0000-0002-3077-8898
AD  - Kochi-Umajimura Yuzu Health Research Course, Kochi Medical School, Kochi 
      University, Nankoku 783-8505, Japan.
FAU - Toutani, Mochifumi
AU  - Toutani M
AD  - Umajimura Agricultural Cooperative, Kochi 781-6201, Japan.
FAU - Mizobuchi, Shunji
AU  - Mizobuchi S
AUID- ORCID: 0000-0003-1564-0898
AD  - Kochi-Umajimura Yuzu Health Research Course, Kochi Medical School, Kochi 
      University, Nankoku 783-8505, Japan.
LA  - eng
GR  - 7002-72/Umajimura Agricultural Cooperative/
PT  - Journal Article
DEP - 20240226
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (NF-E2-Related Factor 2)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Plant Oils)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - *Dermatitis, Atopic/drug therapy
MH  - NF-E2-Related Factor 2
MH  - Skin/pathology
MH  - Immunoglobulin E
MH  - Dermatophagoides farinae
MH  - Eating
MH  - Plant Oils/pharmacology
MH  - Disease Models, Animal
PMC - PMC10932159
OTO - NOTNLM
OT  - Nrf2
OT  - antioxidant effect
OT  - atopic dermatitis
OT  - limonin
OT  - yuzu seed oil
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/13 06:46
MHDA- 2024/03/14 06:46
PMCR- 2024/02/26
CRDT- 2024/03/13 01:22
PHST- 2024/01/30 00:00 [received]
PHST- 2024/02/21 00:00 [revised]
PHST- 2024/02/23 00:00 [accepted]
PHST- 2024/03/14 06:46 [medline]
PHST- 2024/03/13 06:46 [pubmed]
PHST- 2024/03/13 01:22 [entrez]
PHST- 2024/02/26 00:00 [pmc-release]
AID - ijms25052689 [pii]
AID - ijms-25-02689 [pii]
AID - 10.3390/ijms25052689 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Feb 26;25(5):2689. doi: 10.3390/ijms25052689.