PMID- 38474815
OWN - NLM
STAT- MEDLINE
DCOM- 20240314
LR  - 20240315
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 16
IP  - 5
DP  - 2024 Feb 28
TI  - The Maternal Omega-3 Long-Chain Polyunsaturated Fatty Acid Concentration in Early 
      Pregnancy and Infant Neurodevelopment: The ECLIPSES Study.
LID - 10.3390/nu16050687 [doi]
LID - 687
AB  - Omega-3 Long-Chain Polyunsaturated Fatty Acids (n-3 LCPUFAs) play a key role in 
      early neurodevelopment, but evidence from observational and clinical studies 
      remains inconsistent. This study investigates the association between maternal 
      n-3 LCPUFA, Docosahexaenoic Acid (DHA), and eicosapentaenoic acid (EPA) 
      concentrations during pregnancy and infant development functioning at 40 days. 
      This study includes 348 mother-infant pairs. Maternal serum concentrations were 
      assessed in the first and third trimesters alongside sociodemographic, clinical, 
      nutritional, psychological, and obstetrical data. At 40 days, the Bayley Scales 
      of Infant and Toddler Development, Third Edition (BSID-III) was administered. An 
      adjusted analysis revealed that lower first-trimester n-3 LCPUFA and DHA 
      concentrations are associated with better infant motor development. These results 
      underscore the potential significance of the maternal n-3 LCPUFA status in early 
      pregnancy for influencing fetal neurodevelopment. However, the complexity of 
      these associations necessitates further investigation, emphasizing the urgent 
      need for additional studies to comprehensively elucidate the nuanced interplay 
      between the maternal n-3 LCPUFA status and infant neurodevelopment.
FAU - Shahabi, Behnaz
AU  - Shahabi B
AUID- ORCID: 0000-0002-9313-5750
AD  - Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i 
      Virgili, 43201 Reus, Spain.
AD  - Pere Virgili Institute for Health Research (IISPV), Universitat Rovira i Virgili, 
      43201 Reus, Spain.
FAU - Hernandez-Martinez, Carmen
AU  - Hernandez-Martinez C
AUID- ORCID: 0000-0001-6328-8679
AD  - Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i 
      Virgili, 43201 Reus, Spain.
AD  - Pere Virgili Institute for Health Research (IISPV), Universitat Rovira i Virgili, 
      43201 Reus, Spain.
AD  - Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, 
      43003 Tarragona, Spain.
FAU - Voltas, Nuria
AU  - Voltas N
AUID- ORCID: 0000-0001-8855-0282
AD  - Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i 
      Virgili, 43201 Reus, Spain.
AD  - Pere Virgili Institute for Health Research (IISPV), Universitat Rovira i Virgili, 
      43201 Reus, Spain.
AD  - Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, 
      43003 Tarragona, Spain.
AD  - Serra Hunter Fellow, Department of Psychology, Faculty of Education Sciences and 
      Psychology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
FAU - Canals, Josefa
AU  - Canals J
AUID- ORCID: 0000-0002-6209-9558
AD  - Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i 
      Virgili, 43201 Reus, Spain.
AD  - Pere Virgili Institute for Health Research (IISPV), Universitat Rovira i Virgili, 
      43201 Reus, Spain.
AD  - Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, 
      43003 Tarragona, Spain.
FAU - Arija, Victoria
AU  - Arija V
AUID- ORCID: 0000-0002-1758-0975
AD  - Research Group in Nutrition and Mental Health (NUTRISAM), Universitat Rovira i 
      Virgili, 43201 Reus, Spain.
AD  - Pere Virgili Institute for Health Research (IISPV), Universitat Rovira i Virgili, 
      43201 Reus, Spain.
LA  - eng
GR  - PI12/02777/Instituto de Salud Carlos III/
GR  - PI17/01754/Instituto de Salud Carlos III/
PT  - Journal Article
DEP - 20240228
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Fatty Acids, Omega-3)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
MH  - Infant
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Fatty Acids, Omega-3
MH  - Docosahexaenoic Acids
MH  - Pregnancy Trimester, Third
MH  - Eicosapentaenoic Acid
MH  - Mothers
PMC - PMC10934866
OTO - NOTNLM
OT  - DHA
OT  - EPA
OT  - cognitive development
OT  - infant neurodevelopment
OT  - omega-3
OT  - pregnancy
OT  - serum concentrations
COIS- The authors declare no conflicts of interest. The funders played no role in the 
      study's design, data collection, analysis, manuscript writing, or in the decision 
      to publish.
EDAT- 2024/03/13 06:46
MHDA- 2024/03/14 06:47
PMCR- 2024/02/28
CRDT- 2024/03/13 01:28
PHST- 2024/01/30 00:00 [received]
PHST- 2024/02/26 00:00 [revised]
PHST- 2024/02/26 00:00 [accepted]
PHST- 2024/03/14 06:47 [medline]
PHST- 2024/03/13 06:46 [pubmed]
PHST- 2024/03/13 01:28 [entrez]
PHST- 2024/02/28 00:00 [pmc-release]
AID - nu16050687 [pii]
AID - nutrients-16-00687 [pii]
AID - 10.3390/nu16050687 [doi]
PST - epublish
SO  - Nutrients. 2024 Feb 28;16(5):687. doi: 10.3390/nu16050687.