PMID- 38477348
OWN - NLM
STAT- MEDLINE
DCOM- 20240502
LR  - 20240502
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 78
IP  - 5
DP  - 2024 May
TI  - Longitudinal screening of HLA-risk and HLA-nonrisk children for celiac disease to 
      age 15 years: CiPiS study.
PG  - 1143-1148
LID - 10.1002/jpn3.12181 [doi]
AB  - OBJECTIVES: Autoantibodies against tissue transglutaminase (tTG) are serological 
      markers of celiac disease. The aim was to study the applicability of human 
      leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of 
      celiac disease in a longitudinal birth cohort followed to age 15 years. METHODS: 
      Included were 13,860 HLA-DQ-genotyped children at birth and previously invited to 
      a screening at age 3 and 9 years, respectively. HLA-DQB1*02 and/or DQB1*03:02 
      (HLA-risk) children were compared with non-HLA-DQB1*02 and non-DQB1*03:02 
      (HLA-nonrisk) children. The present study reinvited 12,948/13,860 (93.4%) 
      children at age 15 years of whom 1056/2374 (44.5%) participated in screening at 
      both age 3 and 9 years. Both immunoglobulin A (IgA) and G (IgG) autoantibodies 
      against tTG were analyzed separately in radiobinding assays. Persistently tTG 
      autoantibody-positive children were examined with intestinal biopsy to confirm 
      the diagnosis of celiac disease. RESULTS: At age 3 years, celiac disease was 
      diagnosed in 56/1635 (3.4%) HLA-risk children compared with 0/1824 HLA-nonrisk 
      children (p < 0.001). By age 9 years, celiac disease was diagnosed in 72/1910 
      (3.8%) HLA-risk children compared with 0/2167 HLA-nonrisk children (p < 0.001). 
      Screening at age 15 years detected 14/1071 (1.3%) HLA-risk children positive for 
      IgA-tTG and/or IgG-tTG of whom 12/1071 (1.1%) remained persistently positive. 
      Among those, 10/1071 (0.9%, 95% confidence interval: 0.4%-1.7%) HLA-risk children 
      were diagnosed with celiac disease compared with 0/1303 HLA-nonrisk children 
      (p < 0.001) and 5/491 (1.0%) were negative in screenings at both 3 and 9 years of 
      age. CONCLUSIONS: Screening for celiac disease needs to be performed at multiple 
      timepoints to detect all cases but can be restricted to children at HLA-risk.
CI  - (c) 2024 The Authors. Journal of Pediatric Gastroenterology and Nutrition published 
      by Wiley Periodicals LLC on behalf of European Society for Pediatric 
      Gastroenterology, Hepatology, and Nutrition and North American Society for 
      Pediatric Gastroenterology, Hepatology, and Nutrition.
FAU - Bostrom, Michaela
AU  - Bostrom M
AD  - Celiac Disease and Diabetes Unit, Lund University, Malmo, Sweden.
FAU - Brundin, Charlotte
AU  - Brundin C
AD  - Celiac Disease and Diabetes Unit, Lund University, Malmo, Sweden.
FAU - Bjorck, Sara
AU  - Bjorck S
AD  - Celiac Disease and Diabetes Unit, Lund University, Malmo, Sweden.
FAU - Agardh, Daniel
AU  - Agardh D
AD  - Celiac Disease and Diabetes Unit, Lund University, Malmo, Sweden.
LA  - eng
GR  - None/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240313
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin A)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - 0 (Immunoglobulin G)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DQ beta-Chains)
SB  - IM
MH  - Humans
MH  - *Celiac Disease/diagnosis/immunology/genetics
MH  - Child
MH  - Child, Preschool
MH  - *Transglutaminases/immunology
MH  - Longitudinal Studies
MH  - *Autoantibodies/blood
MH  - Adolescent
MH  - Female
MH  - Male
MH  - *Immunoglobulin A/blood
MH  - *GTP-Binding Proteins/immunology
MH  - Immunoglobulin G/blood
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - HLA-DQ Antigens/genetics
MH  - Mass Screening/methods
MH  - Genotype
MH  - HLA-DQ beta-Chains/genetics
MH  - Risk Factors
MH  - Genetic Predisposition to Disease
OTO - NOTNLM
OT  - prospective
OT  - repeated screening
OT  - tissue transglutaminase autoantibodies
EDAT- 2024/03/13 12:47
MHDA- 2024/05/02 13:01
CRDT- 2024/03/13 08:01
PHST- 2024/02/23 00:00 [revised]
PHST- 2023/12/21 00:00 [received]
PHST- 2024/02/28 00:00 [accepted]
PHST- 2024/05/02 13:01 [medline]
PHST- 2024/03/13 12:47 [pubmed]
PHST- 2024/03/13 08:01 [entrez]
AID - 10.1002/jpn3.12181 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2024 May;78(5):1143-1148. doi: 10.1002/jpn3.12181. 
      Epub 2024 Mar 13.