PMID- 38477953
OWN - NLM
STAT- MEDLINE
DCOM- 20240314
LR  - 20240314
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 22
IP  - 6
DP  - 2023 Dec 28
TI  - Mesenchymal Stem Cell-derived Exosome; An Interesting Nanocarrier to Improve 
      Allergen-specific Intranasal Immunotherapy.
PG  - 561-574
LID - 10.18502/ijaai.v22i6.14645 [doi]
AB  - Increasing the efficacy of allergen-specific intranasal immunotherapy (INIT) has 
      recently been the main goal of several studies to establish this route as a safe 
      delivery method through mucosal pathways. In this case, the present study 
      evaluated the potential of INIT using ovalbumin (OVA)-loaded mesenchymal 
      stromal/stem cell (MSC)-derived exosomes (Exo-OVA) in an allergic asthma mouse 
      model. Together with control groups, sensitized Balb/c mice underwent intranasal 
      immunotherapy with Exo-OVA (10 mug OVA per dose) for three consecutive weeks. 
      Serum-specific immunoglobulin E (IgE) levels, transforming growth factor-beta 
      (TGF-beta), interleukin (IL)-4, and interferon-gamma (IFN-gamma) production by cultured 
      spleen cells, lung histopathologic analysis, and nasopharyngeal lavage fluid 
      cellular examinations were then conducted. The results showed that INIT using 
      Exo-OVA significantly increased IFN-gamma and TGF-beta secretion, while 
      allergen-specific IgE and IL-4 production were dramatically decreased compared to 
      the control group receiving phosphate-buffered saline. In addition, the 
      eosinophil and total cell counts in the nasopharyngeal lavage fluid were reduced, 
      and inflammatory conditions and cell accumulation in lung tissue were 
      ameliorated. In conclusion, the Exo-OVA improved the INIT efficacy compared to 
      free OVA. Therefore, this formulation could be introduced as an effective 
      approach for immunomodulatory purposes with a shorter treatment duration and 
      reduced side effects.
FAU - Dehnavi, Sajad
AU  - Dehnavi S
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 
      AND Department of Immunology, Faculty of Medicine, Aja University of Medical 
      Sciences, Tehran, Iran AND Infectious Diseases Research Center, Aja University of 
      Medical Sciences, Tehran, Iran. sjd72dehnavi@gmail.com.
FAU - Dadmanesh, Maryam
AU  - Dadmanesh M
AD  - Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, 
      Iran AND Department of Infectious Diseases, Faculty of Medicine, Aja University 
      of Medical Sciences, Tehran, Iran. dr.dadmanesh@gmail.com.
FAU - Hosseini Rouzbahani, Negin
AU  - Hosseini Rouzbahani N
AD  - Department of Immunology, Faculty of Medicine, Aja University of Medical 
      Sciences, Tehran, Iran AND Infectious Diseases Research Center, Aja University of 
      Medical Sciences, Tehran, Iran. signet.h313@gmail.com.
FAU - Karimi, Mahmood
AU  - Karimi M
AD  - Department of Pulmonology, Faculty of Medicine, Aja University of Medical 
      Sciences, Tehran, Iran. Dr.karimi.ma@gmail.com.
FAU - Asadirad, Ali
AU  - Asadirad A
AD  - Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran AND Cancer Research Center, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran. ali.asadira@gmail.com.
FAU - Gholami, Mohammad
AU  - Gholami M
AD  - Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, 
      Iran AND Department of Medical Microbiology, Faculty of Medicine, Aja University 
      of Medical Sciences, Tehran, Iran. mohammadg19@gmail.com.
FAU - Ghorban, Khodayar
AU  - Ghorban K
AD  - Department of Immunology, Faculty of Medicine, Aja University of Medical 
      Sciences, Tehran, Iran. kh.ghorban@gmail.con.
LA  - eng
PT  - Journal Article
DEP - 20231228
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 9006-59-1 (Ovalbumin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Allergens)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Exosomes
MH  - Desensitization, Immunologic
MH  - Ovalbumin
MH  - Immunoglobulin E
MH  - Transforming Growth Factor beta
MH  - Allergens
OTO - NOTNLM
OT  - Allergen immunotherapy
OT  - Exosomes
OT  - Immunomodulation
OT  - Mesenchymal stromal cell
OT  - Nanoparticle drug delivery system
EDAT- 2024/03/13 12:45
MHDA- 2024/03/14 06:47
CRDT- 2024/03/13 11:44
PHST- 2023/02/07 00:00 [received]
PHST- 2023/11/05 00:00 [accepted]
PHST- 2024/03/14 06:47 [medline]
PHST- 2024/03/13 12:45 [pubmed]
PHST- 2024/03/13 11:44 [entrez]
AID - 10.18502/ijaai.v22i6.14645 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2023 Dec 28;22(6):561-574. doi: 
      10.18502/ijaai.v22i6.14645.