PMID- 38478126
OWN - NLM
STAT- Publisher
LR  - 20240313
IS  - 1865-7125 (Electronic)
IS  - 0341-0382 (Linking)
DP  - 2024 Mar 14
TI  - Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery 
      system.
LID - 10.1515/znc-2023-0148 [doi]
AB  - Although chemotherapy is still the most preferred treatment for cancer, most 
      chemotherapeutic agents target both cancer cells and healthy cells and cause 
      serious side effects due to high toxicity. Improved drug delivery systems (DDSs), 
      which enhance the efficacy of current chemotherapeutic drugs while reducing their 
      toxicity, offer potential solutions to these challenges. Chitosan (CS) and its 
      derivatives are biopolymers with biodegradable, biocompatible, and low-toxicity 
      properties, and their structure allows for convenient chemical and mechanical 
      modifications. In its role as a therapeutic agent, CS can impede the 
      proliferation of tumor cells through the inhibition of angiogenesis and 
      metastasis, as well as by triggering apoptosis. CS and its derivatives are also 
      frequently preferred as DDSs due to their properties such as high drug-carrying 
      capacity, polycationic structure, long-term circulation, and direct targeting of 
      cancer cells. Various therapeutic agents linked to CS and its derivatives 
      demonstrate potent anticancer effects with advantages such as reduced side 
      effects compared to the original drugs, owing to factors like targeted 
      distribution within cancer tissues and sustained release. This review emphasizes 
      the utilization of CS and its derivatives, both as therapeutic agents and as 
      carriers for established chemotherapeutic drugs.
CI  - (c) 2024 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Atmaca, Harika
AU  - Atmaca H
AUID- ORCID: 0000-0002-8459-4373
AD  - Department of Biology 52953 , Faculty of Engineering and Natural Sciences, Manisa 
      Celal Bayar University , Manisa 45140, Turkiye.
FAU - Oguz, Ferdi
AU  - Oguz F
AD  - Graduate School of Health Sciences, Cellular and Molecular Medicine, Koc 
      University, Istanbul, Turkiye.
FAU - Ilhan, Suleyman
AU  - Ilhan S
AUID- ORCID: 0000-0002-6584-3979
AD  - Department of Biology 52953 , Faculty of Engineering and Natural Sciences, Manisa 
      Celal Bayar University , Manisa 45140, Turkiye.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240314
PL  - Germany
TA  - Z Naturforsch C J Biosci
JT  - Zeitschrift fur Naturforschung. C, Journal of biosciences
JID - 8912155
SB  - IM
OTO - NOTNLM
OT  - anticancer
OT  - chitosan
OT  - drug delivery
OT  - natural polymer
OT  - therapeutic agent
EDAT- 2024/03/13 18:46
MHDA- 2024/03/13 18:46
CRDT- 2024/03/13 12:18
PHST- 2023/11/03 00:00 [received]
PHST- 2024/02/21 00:00 [accepted]
PHST- 2024/03/13 18:46 [medline]
PHST- 2024/03/13 18:46 [pubmed]
PHST- 2024/03/13 12:18 [entrez]
AID - znc-2023-0148 [pii]
AID - 10.1515/znc-2023-0148 [doi]
PST - aheadofprint
SO  - Z Naturforsch C J Biosci. 2024 Mar 14. doi: 10.1515/znc-2023-0148.