PMID- 38478320
OWN - NLM
STAT- Publisher
LR  - 20240313
IS  - 1559-0291 (Electronic)
IS  - 0273-2289 (Linking)
DP  - 2024 Mar 13
TI  - Causal Association of Telomere Length and Loss of Bone: a Directional Mendelian 
      Randomization Study of Multi-Outcomes.
LID - 10.1007/s12010-024-04899-2 [doi]
AB  - This study employed a genome-wide association study (GWAS) to investigate the 
      relationship between telomere length and marginal bone loss (MBL), a marker of 
      bone health and aging. Telomere length, a biological indicator of aging, was 
      analyzed alongside several serum markers of bone loss. Following a screen for 
      appropriate instrumental variables, telomere length was designated as the 
      exposure variable. We conducted the main analysis using random-effects inverse 
      variance weighting (IVW) and supplemented it with MR Egger, weighted median, 
      simple mode, and weighted mode analyses, employing a total of five methods. 
      Positive outcomes underwent scrutiny through heterogeneity analysis, horizontal 
      multiplicity analysis, and leave-one-out plot. Subsequently, the effective gene 
      locus was chosen for a reverse MR analysis, with positive results serving as the 
      exposure variable. We found a causal relationship between telomere length and the 
      expression of osteocalcin (OC), matrix metalloproteinase-3 (MMP-3), and matrix 
      metalloproteinase-12 (MMP-12), key markers of bone metabolism. Our findings 
      suggest that telomere wear and shortening may contribute to increased activity of 
      OC, MMP-3, and MMP-12, thus affecting bone metabolism. However, reverse Mendelian 
      randomization analysis did not indicate a significant impact of OC, MMP-3, and 
      MMP-12 on telomere length, implying a unidirectional relationship. Overall, this 
      meta-analysis underscores the association between telomere length and bone loss, 
      highlighting the importance of timing and duration of telomere wear and 
      shortening in influencing bone metabolism.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Du, Xiaoxun
AU  - Du X
AD  - College of Integrative Chinese and Western Medicine, Tianjin University of 
      Traditional Chinese Medicine, No.10, Poyang Lake Road, Jinghai District, Tianjin, 
      301617, China.
FAU - Guo, Cunliang
AU  - Guo C
AD  - College of Integrative Chinese and Western Medicine, Tianjin University of 
      Traditional Chinese Medicine, No.10, Poyang Lake Road, Jinghai District, Tianjin, 
      301617, China.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Second Clinical Medical School, Guangzhou University of Traditional Chinese 
      Medicine, No.12, Airport Road, Baiyun District, Guangzhou, 510405, Guangdong 
      Province, China.
FAU - Xu, Baoshan
AU  - Xu B
AUID- ORCID: 0000-0002-4407-8745
AD  - Minimally Invasive Spine Surgery, Tianjin Hospital, No.406, Jiefang South Road, 
      Hexi District, Tianjin, 300299, China. baoshanxu99@tmu.edu.cn.
LA  - eng
GR  - Nos.82072491/National Natural Science Foundation of China/
GR  - Nos. 20JCYBJC00820/Natural Science Foundation of Tianjin City/
PT  - Journal Article
DEP - 20240313
PL  - United States
TA  - Appl Biochem Biotechnol
JT  - Applied biochemistry and biotechnology
JID - 8208561
SB  - IM
OTO - NOTNLM
OT  - Bone metabolism
OT  - Causality analysis
OT  - Mendelian randomization
OT  - Telomere length
EDAT- 2024/03/13 18:46
MHDA- 2024/03/13 18:46
CRDT- 2024/03/13 12:25
PHST- 2024/03/04 00:00 [accepted]
PHST- 2024/03/13 18:46 [medline]
PHST- 2024/03/13 18:46 [pubmed]
PHST- 2024/03/13 12:25 [entrez]
AID - 10.1007/s12010-024-04899-2 [pii]
AID - 10.1007/s12010-024-04899-2 [doi]
PST - aheadofprint
SO  - Appl Biochem Biotechnol. 2024 Mar 13. doi: 10.1007/s12010-024-04899-2.