PMID- 38479350
OWN - NLM
STAT- Publisher
LR  - 20240313
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
DP  - 2024 Mar 13
TI  - Glycemic Control and Retinal Microvascular Changes in Type 2 Diabetes Mellitus 
      Patients without Clinical Retinopathy.
LID - 10.4093/dmj.2023.0149 [doi]
AB  - BACKGROUND: To investigate the association of glycemic control and retinal 
      microvascular changes in patients with type 2 diabetes mellitus (T2DM) without 
      diabetic retinopathy (DR). METHODS: This retrospective, observational, cohort 
      study included patients with T2DM without DR. The patients were categorized into 
      intensive control (IC; mean glycosylated hemoglobin [HbA1c] </=7.0%) and moderate 
      control (MC; mean HbA1c >7.0%) groups. Optical coherence tomography (OCT) and 
      swept-source OCT angiography (OCTA) image parameters were compared between three 
      groups, including healthy controls. RESULTS: In total, 259 eyes of 259 
      participants (88 IC, 81 MC, and 90 controls) were included. The foveal avascular 
      zone area was significantly larger in the MC group than IC and control groups 
      (all P<0.05). The IC group had lower vessel density in the superficial retinal 
      layer and deep retinal layer than the controls (all P<0.05). The choriocapillaris 
      (CC) flow deficit (FD) was significantly greater in the MC group than in the IC 
      and control groups (18.2%, 16.7%, and 14.2%, respectively; all P<0.01). In 
      multivariate regression analysis, CC-FD was associated with the mean HbA1c level 
      (P=0.008). There were no significant differences in OCT parameters among the 
      groups. CONCLUSION: OCTA revealed that early CC impairment is associated with 
      HbA1c levels; the CC changes precede clinically apparent DR. The OCTA parameters 
      differed among the groups according to the degree of glycemic control. Our 
      results suggest that microvascular changes precede DR and are closely related to 
      glycemic control.
FAU - Lee, Kangmin
AU  - Lee K
AD  - Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea.
FAU - Lee, Ga Hye
AU  - Lee GH
AD  - Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea.
FAU - Lee, Seung Eun
AU  - Lee SE
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Dongguk University Ilsan Hospital, Goyang, Korea.
FAU - Yang, Jee Myung
AU  - Yang JM
AD  - Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea.
FAU - Bae, Kunho
AU  - Bae K
AD  - Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20240313
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
SB  - IM
OTO - NOTNLM
OT  - Choroid
OT  - Diabetic retinopathy
OT  - Glycated hemoglobin
OT  - Glycemic control
OT  - Tomography, optical coherence
EDAT- 2024/03/14 00:42
MHDA- 2024/03/14 00:42
CRDT- 2024/03/13 19:15
PHST- 2023/05/15 00:00 [received]
PHST- 2023/12/15 00:00 [accepted]
PHST- 2024/03/14 00:42 [medline]
PHST- 2024/03/14 00:42 [pubmed]
PHST- 2024/03/13 19:15 [entrez]
AID - dmj.2023.0149 [pii]
AID - 10.4093/dmj.2023.0149 [doi]
PST - aheadofprint
SO  - Diabetes Metab J. 2024 Mar 13. doi: 10.4093/dmj.2023.0149.