PMID- 38481205
OWN - NLM
STAT- MEDLINE
DCOM- 20240315
LR  - 20240316
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Mar 13
TI  - Vogt-Koyanagi-Harada disease developed during chemotherapy for Hodgkin lymphoma: 
      a case report.
PG  - 115
LID - 10.1186/s12886-024-03386-w [doi]
LID - 115
AB  - BACKGROUND: Ocular manifestations are known for non-Hodgkin lymphoma, but are 
      rare for Hodgkin lymphoma. We report a case of Vogt-Koyanagi-Harada (VKH) disease 
      presenting as serous retinal detachment and uveitis in both eyes in a child 
      undergoing chemotherapy for Hodgkin lymphoma. CASE PRESENTATION: The patient was 
      a 7-year-old boy with stage IIB Hodgkin lymphoma (nodular lymphocyte predominant 
      type) who was undergoing chemotherapy, including 2 cycles of the OEPA regimen and 
      1 cycle of the COPDAC regimen. Two days after the end of the COPDAC regimen, the 
      patient complained of headache and of blurred and decreased vision in both eyes. 
      On the basis of optic symptoms, such as uveitis and serous retinal detachment in 
      both eyes, increased cell counts in cerebrospinal fluid, and positivity for human 
      leukocyte antigen (HLA)-DR4 in peripheral blood cells, incomplete VKH disease was 
      diagnosed. Intravenous treatment with high-dose prednisolone (60mg/m(2)/day) for 
      7 days improved both visual acuity and serous retinal detachment and enabled the 
      remains of the COPDAC chemotherapy cycle to be administered. With prednisolone 
      treatment, visual acuity improved from 20/500 to 20/20 in the right eye and from 
      20/63 to 20/25 in the left eye. Because multiple vitiligo lesions later appeared 
      in the abdomen, complete VKH disease was finally diagnosed. CONCLUSION: The onset 
      of VKH disease occurred during chemotherapy for Hodgkin lymphoma. The patient was 
      HLA-DR4-positive and might have had a predisposition to develop autoimmune 
      diseases, including VKH disease. However, the anticancer drugs administered to 
      this patient have not been reported to cause uveitis. Whether Hodgkin lymphoma 
      triggered the development of VKH remains unclear. Early diagnosis of VKH disease 
      and prompt treatment with high-dose prednisone enabled the patient to maintain 
      good visual function despite chemotherapy for Hodgkin lymphoma.
CI  - (c) 2024. The Author(s).
FAU - Koyama, Mutsumi
AU  - Koyama M
AD  - Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8561, Tokyo, Japan.
FAU - Nishijima, Euido
AU  - Nishijima E
AD  - Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8561, Tokyo, Japan.
FAU - Honda, Takaya
AU  - Honda T
AD  - Department of Pediatrics, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan.
FAU - Gonmori-Ohta, Chizuru
AU  - Gonmori-Ohta C
AD  - Department of Pediatrics, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan.
FAU - Sasamoto, Takeaki
AU  - Sasamoto T
AD  - Department of Pediatrics, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan.
FAU - Tanaka, Katsuyuki
AU  - Tanaka K
AD  - Department of Pediatrics, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan.
FAU - Watanabe, Akira
AU  - Watanabe A
AD  - Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8561, Tokyo, Japan.
FAU - Nakano, Tadashi
AU  - Nakano T
AD  - Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8561, Tokyo, Japan.
FAU - Akiyama, Masaharu
AU  - Akiyama M
AD  - Department of Pediatrics, The Jikei University School of Medicine, 3-25-8, 
      Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan. makiyama@jikei.ac.jp.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20240313
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Glucocorticoids)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Male
MH  - Child
MH  - Humans
MH  - *Uveomeningoencephalitic Syndrome/chemically induced/diagnosis/drug therapy
MH  - *Retinal Detachment/drug therapy
MH  - *Hodgkin Disease/diagnosis/drug therapy
MH  - Glucocorticoids/therapeutic use
MH  - Prednisolone/therapeutic use
PMC - PMC10935796
OTO - NOTNLM
OT  - Child
OT  - Hodgkin lymphoma
OT  - Uveitis
OT  - Vogt-Koyanagi-Harada disease
COIS- The authors declare no competing interests.
EDAT- 2024/03/14 06:46
MHDA- 2024/03/15 06:43
PMCR- 2024/03/13
CRDT- 2024/03/14 03:21
PHST- 2023/09/05 00:00 [received]
PHST- 2024/03/07 00:00 [accepted]
PHST- 2024/03/15 06:43 [medline]
PHST- 2024/03/14 06:46 [pubmed]
PHST- 2024/03/14 03:21 [entrez]
PHST- 2024/03/13 00:00 [pmc-release]
AID - 10.1186/s12886-024-03386-w [pii]
AID - 3386 [pii]
AID - 10.1186/s12886-024-03386-w [doi]
PST - epublish
SO  - BMC Ophthalmol. 2024 Mar 13;24(1):115. doi: 10.1186/s12886-024-03386-w.