PMID- 38481310
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240316
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 16
IP  - 1
DP  - 2024 Mar 14
TI  - Predictive effect of triglyceride-glucose index on No-Reflow Phenomenon in 
      patients with type 2 diabetes mellitus and acute myocardial infarction undergoing 
      primary percutaneous coronary intervention.
PG  - 67
LID - 10.1186/s13098-024-01306-y [doi]
LID - 67
AB  - OBJECTIVE: Triglyceride glucose (TyG) index is considered as a new alternative 
      marker of insulin resistance and a clinical predictor of type 2 diabetes mellitus 
      (T2DM) combined with coronary artery disease. However, the prognostic value of 
      TyG index on No-Reflow (NR) Phenomenon in T2DM patients with acute myocardial 
      infarction (AMI) remains unclear. METHODS: In this retrospective study, 1683 
      patients with T2DM and AMI underwent primary percutaneous coronary intervention 
      (PCI) were consecutively included between January 2014 and December 2019. The 
      study population was divided into two groups as follows: Reflow (n = 1277) and 
      No-reflow (n = 406) group. The TyG index was calculated as the ln [fasting 
      triglycerides (mg/dL)xfasting plasma glucose (mg/dL)/2].Multivariable logistic 
      regression models and receiver-operating characteristic curve analysis were 
      conducted to predict the possible risk of no-reflow. Net Reclassification 
      Improvement (NRI) and Integrated Discrimination Improvement (IDI) were calculated 
      to determine the ability of the TyG index to contribute to the baseline risk 
      model. RESULTS: Multivariable logistic regression models revealed that the TyG 
      index was positively associated with NR[OR,95%CI:5.03,(2.72,9.28),p<0.001] in 
      patients with T2DM and AMI. The area under the curve (AUC) of the TyG index 
      predicting the occurrence of NR was 0.645 (95% CI 0.615-0.673; p < 0.001)], with 
      the cut-off value of 8.98. The addition of TyG index to a baseline risk model had 
      an incremental effect on the predictive value for NR [net reclassification 
      improvement (NRI): 0.077(0.043to 0.111), integrated discrimination improvement 
      (IDI): 0.070 (0.031to 0.108), all p < 0.001]. CONCLUSIONS: High TyG index was 
      associated with an increased risk of no-reflow after PCI in AMI patients with 
      T2DM. The TyG index may be a valid predictor of NR phenomenon of patients with 
      T2DM and AMI. Early recognition of NR is critical to improve outcomes with AMI 
      and T2DM patients.
CI  - (c) 2024. The Author(s).
FAU - Ma, Juan
AU  - Ma J
AD  - School of Clinical Medicine, Ningxia Medical University, 750004, Yinchuan, 
      People's Republic of China.
FAU - Wang, Mohan
AU  - Wang M
AD  - School of Clinical Medicine, Ningxia Medical University, 750004, Yinchuan, 
      People's Republic of China.
FAU - Wu, Peng
AU  - Wu P
AD  - School of Clinical Medicine, Ningxia Medical University, 750004, Yinchuan, 
      People's Republic of China.
FAU - Ma, Xueping
AU  - Ma X
AD  - Heart Centre, Department of Cardiovascular Diseases, General Hospital of Ningxia 
      Medical University, 750004, Yinchuan, Ningxia, People's Republic of China.
FAU - Chen, Dapeng
AU  - Chen D
AD  - Heart Centre, Department of Cardiovascular Diseases, General Hospital of Ningxia 
      Medical University, 750004, Yinchuan, Ningxia, People's Republic of China.
FAU - Jia, Shaobin
AU  - Jia S
AD  - Heart Centre, Department of Cardiovascular Diseases, General Hospital of Ningxia 
      Medical University, 750004, Yinchuan, Ningxia, People's Republic of China. 
      jsbxn@163.com.
FAU - Yan, Ning
AU  - Yan N
AD  - Heart Centre, Department of Cardiovascular Diseases, General Hospital of Ningxia 
      Medical University, 750004, Yinchuan, Ningxia, People's Republic of China. 
      yanning169@yahoo.com.
LA  - eng
GR  - 2023AAC02069/The Natural Science Foundation of Ningxia/
GR  - 2022AAC05058/The Natural Science Foundation of Ningxia/
PT  - Journal Article
DEP - 20240314
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC10938834
OTO - NOTNLM
OT  - Acute myocardial infarction (AMI)
OT  - No-reflow
OT  - Triglyceride-glucose index (TyG index)
OT  - Type 2 diabetes mellitus (T2DM)
COIS- The authors have no conflict of interest to declare.
EDAT- 2024/03/14 06:46
MHDA- 2024/03/14 06:47
PMCR- 2024/03/14
CRDT- 2024/03/14 03:31
PHST- 2023/12/28 00:00 [received]
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/14 06:47 [medline]
PHST- 2024/03/14 06:46 [pubmed]
PHST- 2024/03/14 03:31 [entrez]
PHST- 2024/03/14 00:00 [pmc-release]
AID - 10.1186/s13098-024-01306-y [pii]
AID - 1306 [pii]
AID - 10.1186/s13098-024-01306-y [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2024 Mar 14;16(1):67. doi: 10.1186/s13098-024-01306-y.