PMID- 38483069
OWN - NLM
STAT- Publisher
LR  - 20240314
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Linking)
DP  - 2024 Mar 14
TI  - Prognosis in meningoencephalitis of unknown origin in dogs: Risk factors 
      associated with survival, clinical relapse, and long-term disability.
LID - 10.1111/jvim.17037 [doi]
AB  - BACKGROUND: Meningoencephalitis of unknown origin (MUO) comprises a group of 
      noninfectious inflammatory diseases affecting the central nervous system of dogs. 
      Previous studies have reported individual risk factors for survival but 
      prognostication for MUO remains challenging. OBJECTIVES: Identify clinical 
      prognostic variables in dogs with MUO. ANIMALS: A retrospective study of 447 dogs 
      presented to 2 UK referral hospitals and diagnosed with MUO. METHODS: Medical 
      records of dogs diagnosed with MUO were retrospectively reviewed. Multivariable 
      logistic regression was used for the identification of risk factors for survival 
      and Cox proportional hazards analysis for the identification of risk factors for 
      clinical relapse. RESULTS: Eighty-two percent (366/447) of dogs with presumptive 
      MUO survived to discharge and 63.5% (284/447) were alive at 6 months; 36% of the 
      latter (103/284) had persistent neurological deficits. Breed (pugs; P = .03), 
      epileptic seizures (P < .001), paresis (P < .001), and higher neurodisability 
      scale (NDS) score (P < .001) at presentation were negatively associated with 
      survival to 6 months. Dogs with persistent deficits had higher NDS scores on 
      presentation (P = .001). Median follow-up time was 11 months (interquartile range 
      [IQR], 1-24) and 50.6% (160/316) relapsed during treatment (median time to 
      relapse, 7 months; IQR, 2-15). Incomplete resolution of the clinical signs during 
      the 6 months after diagnosis (P < .001), higher NDS score (P < .001), and longer 
      duration of the clinical signs (P < .001) were associated with relapse. 
      CONCLUSIONS AND CLINICAL IMPORTANCE: Knowledge of risk factors associated with 
      survival, incomplete recovery and clinical relapse in MUO can help guide 
      monitoring and treatment and improve owner communications regarding prognosis for 
      this debilitating disease.
CI  - (c) 2024 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Goncalves, Rita
AU  - Goncalves R
AUID- ORCID: 0000-0001-5420-9801
AD  - Department of Veterinary Science, Small Animal Teaching Hospital, University of 
      Liverpool, Neston, UK.
AD  - Department of Musculoskeletal and Ageing Science, Institute of Lifecourse and 
      Medical Sciences, University of Liverpool, Neston, UK.
FAU - De Decker, Steven
AU  - De Decker S
AUID- ORCID: 0000-0002-2505-2152
AD  - Department of Clinical Science and Services, Royal Veterinary College, University 
      of London, Hatfield, UK.
FAU - Walmsley, Gemma
AU  - Walmsley G
AUID- ORCID: 0009-0000-0727-8265
AD  - Department of Veterinary Science, Small Animal Teaching Hospital, University of 
      Liverpool, Neston, UK.
AD  - Department of Musculoskeletal and Ageing Science, Institute of Lifecourse and 
      Medical Sciences, University of Liverpool, Neston, UK.
FAU - Maddox, Thomas W
AU  - Maddox TW
AD  - Department of Veterinary Science, Small Animal Teaching Hospital, University of 
      Liverpool, Neston, UK.
AD  - Department of Musculoskeletal and Ageing Science, Institute of Lifecourse and 
      Medical Sciences, University of Liverpool, Neston, UK.
LA  - eng
PT  - Journal Article
DEP - 20240314
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
SB  - IM
OTO - NOTNLM
OT  - MUO
OT  - canine
OT  - mortality
OT  - outcome
OT  - prognosis
OT  - relapse
EDAT- 2024/03/14 12:48
MHDA- 2024/03/14 12:48
CRDT- 2024/03/14 08:23
PHST- 2023/09/13 00:00 [received]
PHST- 2024/02/26 00:00 [accepted]
PHST- 2024/03/14 12:48 [medline]
PHST- 2024/03/14 12:48 [pubmed]
PHST- 2024/03/14 08:23 [entrez]
AID - 10.1111/jvim.17037 [doi]
PST - aheadofprint
SO  - J Vet Intern Med. 2024 Mar 14. doi: 10.1111/jvim.17037.