PMID- 38483154
OWN - NLM
STAT- MEDLINE
DCOM- 20240429
LR  - 20240502
IS  - 1473-6551 (Electronic)
IS  - 1350-7540 (Linking)
VI  - 37
IP  - 3
DP  - 2024 Jun 1
TI  - Genetic predisposition to autoimmune encephalitis and paraneoplastic neurological 
      syndromes.
PG  - 329-337
LID - 10.1097/WCO.0000000000001263 [doi]
AB  - PURPOSE OF REVIEW: We summarize the recent discoveries on genetic predisposition 
      to autoimmune encephalitis and paraneoplastic neurological syndromes (PNS), 
      emphasizing clinical and pathophysiological implications. RECENT FINDINGS: The 
      human leukocyte antigen (HLA) is the most studied genetic factor in autoimmune 
      encephalitis and PNS. The HLA haplotype 8.1, which is widely known to be related 
      to systemic autoimmunity, has been only weakly associated with a few types of 
      autoimmune encephalitis and PNS. However, the strongest and most specific 
      associations have been reported in a subgroup of autoimmune encephalitis that 
      comprises antileucine-rich glioma-inactivated 1 (LGI1) limbic encephalitis, 
      associated with DRB1 *07 : 01 , anticontactin-associated protein-like 2 (CASPR2) 
      limbic encephalitis, associated with DRB1 *11 : 01 , and anti-IgLON5 disease, 
      associated with DRB1 *10 : 01 approximately DQA1 *01 approximately DQB1 *05 . Non-HLA genes have been poorly 
      investigated so far in autoimmune encephalitis, mainly in those lacking HLA 
      associations such as anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, 
      with only a few genome-wide association studies (GWAS) reporting equivocal 
      results principally limited by small sample size. SUMMARY: Genetic predisposition 
      seems to be driven mostly by HLA in a group of autoimmune encephalitis 
      characterized by being nonparaneoplastic and having predominantly IgG4 
      autoantibodies. The contribution of non-HLA genes, especially in those diseases 
      lacking known or strong HLA associations, will require large cohorts enabling 
      GWAS to be powerful enough to render meaningful results.
CI  - Copyright (c) 2024 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Muniz-Castrillo, Sergio
AU  - Muniz-Castrillo S
AD  - Stanford Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, 
      California, USA.
AD  - French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune 
      Encephalitis, Hospices Civils de Lyon.
FAU - Honnorat, Jerome
AU  - Honnorat J
AD  - French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune 
      Encephalitis, Hospices Civils de Lyon.
AD  - MeLiS Institute - UCBL-CNRS UMR 5284 - INSERM U1314, Universite Claude Bernard 
      Lyon 1, Lyon, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20240314
PL  - England
TA  - Curr Opin Neurol
JT  - Current opinion in neurology
JID - 9319162
RN  - 0 (HLA Antigens)
RN  - 0 (Autoantibodies)
RN  - Hashimoto's encephalitis
SB  - IM
MH  - Humans
MH  - *Genetic Predisposition to Disease/genetics
MH  - *Paraneoplastic Syndromes, Nervous System/genetics/immunology
MH  - *Encephalitis/genetics/immunology
MH  - Hashimoto Disease/genetics/immunology
MH  - HLA Antigens/genetics/immunology
MH  - Autoantibodies/immunology
EDAT- 2024/03/14 12:47
MHDA- 2024/04/29 13:57
CRDT- 2024/03/14 09:02
PHST- 2024/04/29 13:57 [medline]
PHST- 2024/03/14 12:47 [pubmed]
PHST- 2024/03/14 09:02 [entrez]
AID - 00019052-202406000-00018 [pii]
AID - 10.1097/WCO.0000000000001263 [doi]
PST - ppublish
SO  - Curr Opin Neurol. 2024 Jun 1;37(3):329-337. doi: 10.1097/WCO.0000000000001263. 
      Epub 2024 Mar 14.