PMID- 38483656
OWN - NLM
STAT- Publisher
LR  - 20240314
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
DP  - 2024 Mar 14
TI  - Mechanistic Insights and Potential Therapeutic Implications of NRF2 in Diabetic 
      Encephalopathy.
LID - 10.1007/s12035-024-04097-5 [doi]
AB  - Diabetic encephalopathy (DE) is a complication of diabetes, especially type 2 
      diabetes (T2D), characterized by damage in the central nervous system and 
      cognitive impairment, which has gained global attention. Despite the extensive 
      research aimed at enhancing our understanding of DE, the underlying mechanism of 
      occurrence and development of DE has not been established. Mounting evidence has 
      demonstrated a close correlation between DE and various factors, such as 
      Alzheimer's disease-like pathological changes, insulin resistance, inflammation, 
      and oxidative stress. Of interest, nuclear factor erythroid 2-related factor 2 
      (NRF2) is a transcription factor with antioxidant properties that is crucial in 
      maintaining redox homeostasis and regulating inflammatory responses. The 
      activation and regulatory mechanisms of NRF2 are a relatively complex process. 
      NRF2 is involved in the regulation of multiple metabolic pathways and confers 
      neuroprotective functions. Multiple studies have provided evidence demonstrating 
      the significant involvement of NRF2 as a critical transcription factor in the 
      progression of DE. Additionally, various molecules capable of activating NRF2 
      expression have shown potential in ameliorating DE. Therefore, it is intriguing 
      to consider NRF2 as a potential target for the treatment of DE. In this review, 
      we aim to shed light on the role and the possible underlying mechanism of NRF2 in 
      DE. Furthermore, we provide an overview of the current research landscape and 
      address the challenges associated with using NRF2 activators as potential 
      treatment options for DE.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Cheng, Xin
AU  - Cheng X
AD  - Department of Integrated Traditional Chinese & Western Medicine, The Second 
      Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, 
      Hunan, 410011, People's Republic of China.
AD  - National Clinical Research Center for Mental Disorder, Changsha, 410011, China.
FAU - Tan, Yejun
AU  - Tan Y
AD  - School of Mathematics, University of Minnesota, Twin Cities, Minneapolis, MN, 
      USA.
FAU - Li, Hongli
AU  - Li H
AD  - Department of Integrated Traditional Chinese & Western Medicine, The Second 
      Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, 
      Hunan, 410011, People's Republic of China.
AD  - National Clinical Research Center for Mental Disorder, Changsha, 410011, China.
FAU - Zhang, Zhen
AU  - Zhang Z
AD  - YangSheng College of Traditional Chinese Medicine, Guizhou University of 
      Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
FAU - Hui, Shan
AU  - Hui S
AD  - Department of Geratology, Hunan Provincial People's Hospital, The First 
      Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
FAU - Zhang, Zheyu
AU  - Zhang Z
AD  - Department of Integrated Traditional Chinese & Western Medicine, The Second 
      Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, 
      Hunan, 410011, People's Republic of China. zhangzy3904@csu.edu.cn.
AD  - National Clinical Research Center for Mental Disorder, Changsha, 410011, China. 
      zhangzy3904@csu.edu.cn.
FAU - Peng, Weijun
AU  - Peng W
AUID- ORCID: 0000-0002-4506-0942
AD  - Department of Integrated Traditional Chinese & Western Medicine, The Second 
      Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, 
      Hunan, 410011, People's Republic of China. pengweijun87@csu.edu.cn.
AD  - National Clinical Research Center for Mental Disorder, Changsha, 410011, China. 
      pengweijun87@csu.edu.cn.
LA  - eng
GR  - No. 81873169/National Natural Science Foundation of China/
GR  - 82104967/National Natural Science Foundation of China/
GR  - No.2022RC1220/Hunan Youth Science and Technology Innovation Talent Project/
GR  - No.2022M711733/Postdoctoral Research Foundation of China/
GR  - No.2020JJ4803/Natural Science Foundation of Hunan Province/
GR  - 2022JJ40728/Natural Science Foundation of Hunan Province/
GR  - No.2021192/Hunan Flagship Department of Integrated Traditional Chinese and 
      Western Medicine, Hunan Scientific Research Program of traditional Chinese 
      Medicine/
PT  - Journal Article
PT  - Review
DEP - 20240314
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
SB  - IM
OTO - NOTNLM
OT  - Cognitive impairment
OT  - Diabetes
OT  - Ferroptosis
OT  - NRF2
OT  - Oxidative stress and inflammation
EDAT- 2024/03/14 18:42
MHDA- 2024/03/14 18:42
CRDT- 2024/03/14 12:20
PHST- 2022/12/01 00:00 [received]
PHST- 2024/03/04 00:00 [accepted]
PHST- 2024/03/14 18:42 [medline]
PHST- 2024/03/14 18:42 [pubmed]
PHST- 2024/03/14 12:20 [entrez]
AID - 10.1007/s12035-024-04097-5 [pii]
AID - 10.1007/s12035-024-04097-5 [doi]
PST - aheadofprint
SO  - Mol Neurobiol. 2024 Mar 14. doi: 10.1007/s12035-024-04097-5.