PMID- 38483678
OWN - NLM
STAT- MEDLINE
DCOM- 20240318
LR  - 20240318
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 51
IP  - 1
DP  - 2024 Mar 14
TI  - Eco-friendly green synthesis of AgNPs from Elaeocarpus serratus fruit extract: 
      potential to antibacterial, antioxidant, cytotoxic effects of colon cancerous 
      cells (HT-29) and its toxicity assessments of marine microcrustacean Artemia 
      nauplii.
PG  - 418
LID - 10.1007/s11033-024-09335-6 [doi]
AB  - BACKGROUND: The present work demonstrated the green synthesis and 
      characterization of silver nanoparticles (AgNPs) utilizing Elaeocarpus serratus 
      fruit extract. The study examined the effectiveness of phytocompounds in fruit 
      extract in reducing Ag(+) to Ag degrees  ions. METHODS: The water-soluble biobased 
      substance production from silver ions to AgNPs in 45 min at room temperature. 
      Surface plasmon resonance (SPR) peak was seen in the UV-visible absorption 
      spectrum of the biologically altered response mixture. Examination with X-ray 
      diffraction (XRD) showed that AgNPs are strong and have a face-centered cubic 
      shape. Scanning electron microscope (SEM) investigation proved the production of 
      AgNPs in a cuboidal shape. RESULTS: The AgNPs demonstrated remarkable 
      antibacterial activity and a potent capacity to neutralize DPPH 
      (2,2-Diphenyl-1-picrylhydrazyl) radicals. The highest growth inhibition was found 
      for E. serratus against S. dysenteriae (18.5 +/- 1.0 mm) and S. aureus 
      (18 +/- 1.2 mm). These nanoparticles exhibited robust antiradical efficacy even at 
      low concentrations. The AgNPs additionally exhibited cytotoxic effects on (HT-29) 
      human colon adenocarcinoma cancer cells. The MTT assay (3-(4, 
      5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) indicated an inhibitory 
      concentration (IC(50)) value of 49.1 +/- 2.33 microg/mL for AgNPs, contrasting with the 
      untreated cells of the negative control. The biotoxicity assessment using A. 
      salina displayed mortality rates ranging from 8 to 69.33%, attributable to the E. 
      serratus synthesized AgNPs. CONCLUSIONS: In our results concluded that simply 
      first-hand information on that E. serattus fruit extract synthesized AgNPs were 
      efficiently synthesized without the addition of any hazardous substances, and 
      that they may be a strong antibacterial, antioxidant, and potential cytotoxic 
      effects for the treatment of colon carcinoma cell lines.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Balamurugan, Venkatachalam
AU  - Balamurugan V
AD  - Division of Crop Molecular Breeding and Stress Physiology, Department of Botany, 
      School of Life Sciences, Periyar University, Periyar Palkalai Nagar, Salem, 
      636011, Tamil Nadu, India.
FAU - Ragavendran, Chinnasamy
AU  - Ragavendran C
AD  - Department of Cariology, Saveetha Institute of Medical and Technical Sciences 
      (SIMATS), Saveetha Dental College and Hospitals, Saveetha University, Chennai, 
      600077, India.
FAU - Arulbalachandran, Dhanarajan
AU  - Arulbalachandran D
AD  - Division of Crop Molecular Breeding and Stress Physiology, Department of Botany, 
      School of Life Sciences, Periyar University, Periyar Palkalai Nagar, Salem, 
      636011, Tamil Nadu, India. arul78bot@gmail.com.
AD  - Division of Crop Molecular Breeding and Stress Physiology, Department of Botany, 
      School of Life Sciences, Periyar University, Periyar Palkalai Nagar, Salem, 
      636011, Tamil Nadu, India. arul78bot@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240314
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 3M4G523W1G (Silver)
RN  - 0 (Antioxidants)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Ions)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Silver/chemistry
MH  - Antioxidants/chemistry
MH  - Artemia
MH  - *Metal Nanoparticles/chemistry
MH  - Fruit/chemistry
MH  - Staphylococcus aureus
MH  - *Adenocarcinoma
MH  - *Colonic Neoplasms/drug therapy
MH  - Anti-Bacterial Agents
MH  - *Antineoplastic Agents/pharmacology/chemistry
MH  - HT29 Cells
MH  - Ions
MH  - Plant Extracts/pharmacology/chemistry
OTO - NOTNLM
OT  - Green synthesis. AgNPs. Antibacterial. Colon cancerous cells. Artemia salina
EDAT- 2024/03/14 18:42
MHDA- 2024/03/18 06:42
CRDT- 2024/03/14 12:20
PHST- 2023/10/05 00:00 [received]
PHST- 2024/02/08 00:00 [accepted]
PHST- 2024/03/18 06:42 [medline]
PHST- 2024/03/14 18:42 [pubmed]
PHST- 2024/03/14 12:20 [entrez]
AID - 10.1007/s11033-024-09335-6 [pii]
AID - 10.1007/s11033-024-09335-6 [doi]
PST - epublish
SO  - Mol Biol Rep. 2024 Mar 14;51(1):418. doi: 10.1007/s11033-024-09335-6.