PMID- 38484905
OWN - NLM
STAT- MEDLINE
DCOM- 20240409
LR  - 20240409
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 189
DP  - 2024 May
TI  - Impact of combined alpha-lipoic acid and mitoquinone supplementation on 
      myocardial infarction in aged rats: Heart performance and molecular mechanisms.
PG  - 112402
LID - S0531-5565(24)00044-5 [pii]
LID - 10.1016/j.exger.2024.112402 [doi]
AB  - BACKGROUND: This study aimed to investigate the effects of combined alpha-lipoic 
      acid (ALA) and mitoquinone (Mito Q) supplementation on cardiac function and the 
      underlying mechanisms in aged rats with myocardial infarction (MI). METHODS: The 
      aged rats underwent left anterior descending artery (LADA) occlusion for 30 min, 
      followed by reperfusion for 24 h. ALA (100 mg/kg, gavage) and Mito Q (10 mg/kg, 
      IP) were administered daily for two weeks before ischemia. Cardiac function, 
      inflammatory, and apoptotic markers were evaluated 24 h after ischemia. RESULTS: 
      The results of this study indicated that the administration of the combination of 
      ALA and Mito Q significantly improved cardiac function. This improvement was 
      linked to a reduction in the expression of pro-inflammatory cytokines TNF-alpha, 
      IL-6, and IL-1beta (P < 0.001) and apoptotic markers (Bax, caspase-3, and Cyt-c), as 
      well as a decrease in the percentage of TUNEL-positive cells (P < 0.001). 
      CONCLUSION: The study revealed that combined intervention synergistically 
      mitigated cardiac dysfunction by suppressing inflammatory and apoptotic pathways 
      in aged rats with MI. Further research is needed to validate the potential of ALA 
      and Mito Q as therapeutic options for elderly people at risk of heart attacks.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Nemati, Samira
AU  - Nemati S
AD  - Research Center of Physiology, Semnan University of Medical Sciences, Iran.
FAU - Zavvari-Oskuye, Zohreh
AU  - Zavvari-Oskuye Z
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Iran; 
      Student Research Committee, Tabriz University of Medical Sciences, Iran.
FAU - Bafadam, Soleyman
AU  - Bafadam S
AD  - Molecular Medicine Research Center, Tabriz University of Medical Sciences, Iran; 
      Department of Physiology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Iran; Student Research Committee, Tabriz University of Medical 
      Sciences, Iran.
FAU - Mokhtari, Behnaz
AU  - Mokhtari B
AD  - Molecular Medicine Research Center, Tabriz University of Medical Sciences, Iran; 
      Department of Physiology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Iran.
FAU - Badalzadeh, Reza
AU  - Badalzadeh R
AD  - Molecular Medicine Research Center, Tabriz University of Medical Sciences, Iran; 
      Department of Physiology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Iran.
FAU - Vakili, Abedin
AU  - Vakili A
AD  - Research Center of Physiology, Semnan University of Medical Sciences, Iran. 
      Electronic address: abvakili@semums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20240319
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - 47BYS17IY0 (mitoquinone)
RN  - 0 (Organophosphorus Compounds)
RN  - 1339-63-5 (Ubiquinone)
SB  - IM
MH  - Humans
MH  - Aged
MH  - Rats
MH  - Animals
MH  - *Thioctic Acid/pharmacology/therapeutic use
MH  - Rats, Sprague-Dawley
MH  - *Myocardial Infarction/drug therapy
MH  - Dietary Supplements
MH  - Apoptosis
MH  - *Organophosphorus Compounds
MH  - Ubiquinone/*analogs & derivatives
OTO - NOTNLM
OT  - Aged rats
OT  - Alpha-lipoic acid
OT  - Apoptosis
OT  - Combination
OT  - Inflammation
OT  - Mito Q
OT  - Myocardial infarction
COIS- Declaration of competing interest The authors state that they have no conflicting 
      interests. They also confirm that they have no financial or non-financial 
      interests in the subject matter or materials discussed in this manuscript, and 
      are not associated or engaged with any organization or entity that does.
EDAT- 2024/03/15 00:43
MHDA- 2024/04/09 06:45
CRDT- 2024/03/14 20:26
PHST- 2023/11/25 00:00 [received]
PHST- 2024/01/16 00:00 [revised]
PHST- 2024/03/11 00:00 [accepted]
PHST- 2024/04/09 06:45 [medline]
PHST- 2024/03/15 00:43 [pubmed]
PHST- 2024/03/14 20:26 [entrez]
AID - S0531-5565(24)00044-5 [pii]
AID - 10.1016/j.exger.2024.112402 [doi]
PST - ppublish
SO  - Exp Gerontol. 2024 May;189:112402. doi: 10.1016/j.exger.2024.112402. Epub 2024 
      Mar 19.