PMID- 38485470
OWN - NLM
STAT- MEDLINE
DCOM- 20240409
LR  - 20240409
IS  - 1526-4602 (Electronic)
IS  - 1525-7797 (Linking)
VI  - 25
IP  - 4
DP  - 2024 Apr 8
TI  - Eumelanin-like Poly(levodopa) Nanoscavengers for Inflammation Disease Therapy.
PG  - 2563-2573
LID - 10.1021/acs.biomac.4c00092 [doi]
AB  - In the current years, polydopamine nanoparticles (PDA NPs) have been extensively 
      investigated as an eumelanin mimic. However, unlike natural eumelanin, PDA NPs 
      contain no 5,6-dihydroxyindole-2-carboxylic acid (DHICA)-derived units and may be 
      limited in certain intrinsic properties; superior eumelanin-like nanomaterials 
      are still actively being sought. Levodopa (l-DOPA) is a natural eumelanin 
      precursor and expected to convert into DHICA and further remain within the final 
      product through covalent or physical interactions. Herein, poly(levodopa) 
      nanoparticles [P(l-DOPA) NPs] were synthesized with the assistance of zinc oxide 
      as a supplement to synthetic eumelanin. This study found that P(l-DOPA) NPs had 
       approximately 90% DHICA-derived subunits on their surface and exhibited superior antioxidant 
      activity compared to PDA NPs due to their looser polymeric microstructure. 
      Benefitting from a stronger ROS scavenging ability, P(l-DOPA) NPs outperformed 
      PDA NPs in treating cellular oxidative stress and acute inflammation. This 
      research opens up new possibilities for the development and application of novel 
      melanin-like materials.
FAU - Wang, Xianheng
AU  - Wang X
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu 610065, China.
FAU - Zhang, Jianhua
AU  - Zhang J
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu 610065, China.
FAU - Yang, Lei
AU  - Yang L
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu 610065, China.
FAU - Wang, Tianyou
AU  - Wang T
AUID- ORCID: 0000-0003-2340-3411
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu 610065, China.
FAU - Duan, Gaigai
AU  - Duan G
AD  - Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest 
      Resources, International Innovation Center for Forest Chemicals and Materials, 
      College of Materials Science and Engineering, Nanjing Forestry University, 
      Nanjing 210037, China.
FAU - Gu, Zhipeng
AU  - Gu Z
AUID- ORCID: 0000-0003-4533-6539
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu 610065, China.
FAU - Li, Yiwen
AU  - Li Y
AUID- ORCID: 0000-0002-6874-0350
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu 610065, China.
LA  - eng
PT  - Journal Article
DEP - 20240314
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 12627-86-0 (eumelanin)
RN  - 0 (Melanins)
RN  - 46627O600J (Levodopa)
RN  - 0 (Antioxidants)
SB  - IM
MH  - Humans
MH  - *Melanins/chemistry
MH  - *Levodopa
MH  - Antioxidants
MH  - Inflammation/drug therapy
EDAT- 2024/03/15 00:43
MHDA- 2024/04/09 06:45
CRDT- 2024/03/14 22:33
PHST- 2024/04/09 06:45 [medline]
PHST- 2024/03/15 00:43 [pubmed]
PHST- 2024/03/14 22:33 [entrez]
AID - 10.1021/acs.biomac.4c00092 [doi]
PST - ppublish
SO  - Biomacromolecules. 2024 Apr 8;25(4):2563-2573. doi: 10.1021/acs.biomac.4c00092. 
      Epub 2024 Mar 14.