PMID- 38485579
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1471-5007 (Electronic)
IS  - 1471-4922 (Print)
IS  - 1471-4922 (Linking)
VI  - 40
IP  - 4
DP  - 2024 Apr
TI  - Itaconate as a potential target for antimalarial therapy.
PG  - 275-277
LID - S1471-4922(24)00057-6 [pii]
LID - 10.1016/j.pt.2024.03.003 [doi]
AB  - In a recent publication, Ramalho et al. investigated monocyte-derived dendritic 
      cell (MODC) mobilization in response to Plasmodium infection. The authors showed 
      that elevated levels of itaconate in MODCs results in reduced CD8 T cell 
      activation and that the absence of itaconate is associated with enhanced parasite 
      control.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Bernardi, Jonathon P
AU  - Bernardi JP
AD  - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, 
      USA.
FAU - Nappi, Taylen J
AU  - Nappi TJ
AD  - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, 
      IA, USA.
FAU - Butler, Noah S
AU  - Butler NS
AD  - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, 
      USA; Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa 
      City, IA, USA. Electronic address: noah-butler@uiowa.edu.
LA  - eng
GR  - R01 AI125446/AI/NIAID NIH HHS/United States
GR  - R01 AI127481/AI/NIAID NIH HHS/United States
GR  - R01 AI167058/AI/NIAID NIH HHS/United States
GR  - T32 AI007511/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20240313
PL  - England
TA  - Trends Parasitol
JT  - Trends in parasitology
JID - 100966034
RN  - 0 (Antimalarials)
RN  - Q4516562YH (itaconic acid)
RN  - 0 (Succinates)
SB  - IM
MH  - *Antimalarials/pharmacology/therapeutic use
MH  - Monocytes/metabolism
MH  - CD8-Positive T-Lymphocytes
MH  - Dendritic Cells
MH  - *Succinates
PMC - PMC10994723
MID - NIHMS1973054
OTO - NOTNLM
OT  - PD-L1
OT  - itaconate
OT  - malaria
OT  - metabolism
OT  - mitochondria
OT  - monocyte-derived dendritic cells
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2024/03/15 00:43
MHDA- 2024/04/08 06:42
PMCR- 2025/04/01
CRDT- 2024/03/14 22:59
PHST- 2024/03/04 00:00 [received]
PHST- 2024/03/04 00:00 [accepted]
PHST- 2025/04/01 00:00 [pmc-release]
PHST- 2024/04/08 06:42 [medline]
PHST- 2024/03/15 00:43 [pubmed]
PHST- 2024/03/14 22:59 [entrez]
AID - S1471-4922(24)00057-6 [pii]
AID - 10.1016/j.pt.2024.03.003 [doi]
PST - ppublish
SO  - Trends Parasitol. 2024 Apr;40(4):275-277. doi: 10.1016/j.pt.2024.03.003. Epub 
      2024 Mar 13.